PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
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PolysacDB ID2409
Carbohydrate NameGroup B antigen   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
Microbe NameStreptococcus Group B strain M732   (NCBI Taxonomy)   (Drugpedia)
Basic StructureThis polysaccharide had a molecular size > 5 x 106. Its main chemical constituents were sialic acid (24%), galactose (25%), a sugar tentatively identified as heptose (21%), glucose (13%), glucosamine (10%) and mannose (7%)
BCSDB StructureN/A
Proposed FunctionN/A
Antigenic NatureFormalin-killed whole cell vaccines
Carrier NameNil
Conjugate MethodNil
AntibodiesAntisera
Antibody Type ClassN/A
Assay SystemCapillary precipitin tests, immunodiffusion tests, immunoelectrophoresis
Cross ReactivityThis antisera cross-reacted with the TCA antigenas well as the EDTA-non pH titrated antigen and the group B antigen extracted with formamide from strain 090R or D136C
Proposed EpitopeL-rhamnose was the immunodominant sugar for the formamide-extracted B antigen
IEDB EpitopeN/A
Proposed UtilityThis antisera has helped determine that two antigens that react identically with each other and with similar specificities of antibody, yet with different immunodominant determinants
Curator IDAA + AS
Date of Curation02-05-2011
References80423

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