PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
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PolysacDB ID2405
Carbohydrate NameCell wall antigen (SA I/II)   (Drugpedia)
Carbohydrate ClassGlycoprotein
Microbe NameStreptococcus mutans serotype c   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed FunctionN/A
Antigenic NatureCell wall antigen (SA I/II)
Carrier NameNil
Conjugate MethodNil
AntibodiesMab Guy 1
Antibody Type ClassIgG2a
Assay SystemSolid-phase radioimmunoassy, Competitive inhibition experiments
Cross ReactivityThis Mab was raised against specific carbohydrate epitopes on the SA and not against contaminating c polysaccharide in the SA preparation and was specific to serotype c
Proposed EpitopeGlucose is part of the epitopes of SA recognized by this Mab
IEDB EpitopeN/A
Proposed UtilityHis Mab can be used in local passive immunization to prevent colonization of S. mutans and the development of caries in monkeys and to prevent colonization of S. mutans in human subjects
Curator IDAA + AS
Date of Curation01-05-2011
References2434429

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PolysacDB ID2406
Carbohydrate NameCell wall antigen (SA I/II)   (Drugpedia)
Carbohydrate ClassGlycoprotein
Microbe NameStreptococcus mutans serotype c   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed FunctionN/A
Antigenic NatureCell wall antigen (SA I/II)
Carrier NameNil
Conjugate MethodNil
AntibodiesMab Guy 2
Antibody Type ClassIgG1
Assay SystemSolid-phase radioimmunoassy, Competitive inhibition experiments
Cross ReactivityThis Mab was raised against specific carbohydrate epitopes on the SA and not against contaminating c polysaccharide in the SA preparation and was specific to serotype c
Proposed EpitopeGlucose is part of the epitopes of SA recognized by this Mab
IEDB EpitopeN/A
Proposed UtilityHis Mab can be used in local passive immunization to prevent colonization of S. mutans and the development of caries in monkeys and to prevent colonization of S. mutans in human subjects
Curator IDAA + AS
Date of Curation01-05-2011
References2434429

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PolysacDB ID2407
Carbohydrate NameCell wall antigen (SA I/II)   (Drugpedia)
Carbohydrate ClassGlycoprotein
Microbe NameStreptococcus mutans serotype c   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed FunctionN/A
Antigenic NatureCell wall antigen (SA I/II)
Carrier NameNil
Conjugate MethodNil
AntibodiesMab Guy 3
Antibody Type ClassIgG2a
Assay SystemSolid-phase radioimmunoassy, Competitive inhibition experiments
Cross ReactivityThis Mab was raised against specific carbohydrate epitopes on the SA and not against contaminating c polysaccharide in the SA preparation and was specific to serotype c
Proposed EpitopeGlucose is part of the epitopes of SA recognized by this Mab
IEDB EpitopeN/A
Proposed UtilityHis Mab can be used in local passive immunization to prevent colonization of S. mutans and the development of caries in monkeys and to prevent colonization of S. mutans in human subjects
Curator IDAA + AS
Date of Curation01-05-2011
References2434429

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PolysacDB ID2408
Carbohydrate NameCell wall antigen (SA I/II)   (Drugpedia)
Carbohydrate ClassGlycoprotein
Microbe NameStreptococcus mutans serotype c   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed FunctionN/A
Antigenic NatureCell wall antigen (SA I/II)
Carrier NameNil
Conjugate MethodNil
AntibodiesMab Guy 5
Antibody Type ClassIgG1
Assay SystemSolid-phase radioimmunoassy, Competitive inhibition experiments
Cross ReactivityThis Mab was raised against specific carbohydrate epitopes on the SA and not against contaminating c polysaccharide in the SA preparation and was specific to serotype c
Proposed EpitopeGlucose is part of the epitopes of SA recognized by this Mab
IEDB EpitopeN/A
Proposed UtilityHis Mab can be used in local passive immunization to prevent colonization of S. mutans and the development of caries in monkeys and to prevent colonization of S. mutans in human subjects
Curator IDAA + AS
Date of Curation02-05-2011
References2434429

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