PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613

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PolysacDB ID	1007
Carbohydrate Name	Lipoarabinomannan (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Mycobacterium tuberculosis (NCBI Taxonomy) (Drugpedia)
Basic Structure	Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues, and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor
BCSDB Structure	127448
Proposed Function	T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages
Antigenic Nature	Heat killed Mycobacterium tuberculosis
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab 5c11
Antibody Type Class	IgM
Assay System	Indirect immunofluorescence, ELISA, western blotting
Cross Reactivity	This antibody cross-reacted with large number of mycobacterial species.
Proposed Epitope	Arabinose moiety of Lipoarabinomannan
IEDB Epitope	N/A
Proposed Utility	This antibody has been used in the detection of mycobacteria in clinical samples
Curator ID	AA + AS
Date of Curation	02-01-2010
References	PMC229406

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PolysacDB ID	1008
Carbohydrate Name	Mycolyl-arabinogalactan-peptidoglycan complex (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Mycobacterium tuberculosis (NCBI Taxonomy) (Drugpedia)
Basic Structure	Mycolyl-arabinogalactan-peptidoglycan complex is the fraction of the mycobacterial cell wall left after removing all soluble carbohydrates, proteins and lipids
BCSDB Structure	N/A
Proposed Function	Contains lipoarabinomannan as well as arabinose that are important virulence factors
Antigenic Nature	Heat killed Mycobacterium tuberculosis
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mabs 4f11
Antibody Type Class	IgM
Assay System	Indirect immunofluorescence, ELISA, western blotting
Cross Reactivity	This antibody cross-reacted with large number of mycobacterial species.
Proposed Epitope	Arabinose moiety of Lipoarabinomannan
IEDB Epitope	N/A
Proposed Utility	This antibody has been used in the detection of mycobacteria in clinical samples
Curator ID	AA + AS
Date of Curation	02-01-2010
References	PMC229406

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PolysacDB ID	1009
Carbohydrate Name	Unknown carbohydrate (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Mycobacterium tuberculosis (NCBI Taxonomy) (Drugpedia)
Basic Structure	N/A
BCSDB Structure	N/A
Proposed Function	N/A
Antigenic Nature	Heat killed Mycobacterium tuberculosis
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab 9d8
Antibody Type Class	IgG3
Assay System	Indirect immunofluorescence, ELISA, western blotting
Cross Reactivity	This antibody cross-reacted with M.gordonae, M. gastri, and M. Kansasii
Proposed Epitope	N\A
IEDB Epitope	N/A
Proposed Utility	This antibody has been used in the detection of mycobacteria in clinical samples
Curator ID	AA + AS
Date of Curation	03-01-2010
References	PMC229406

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PolysacDB ID	1010
Carbohydrate Name	Lipoarabinomannan (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Mycobacterium tuberculosis (NCBI Taxonomy) (Drugpedia)
Basic Structure	Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues, and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor
BCSDB Structure	127448
Proposed Function	Reported to suppress T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages. Other reported effects include inhibition of protein kinases, inhibition of the synthesis of mRNA encoding IL-2, IL-5, and granulocyte-macrophage colony stimulating factor (GM-CSF) in human T cells and activation of the complement cascade
Antigenic Nature	Heat killed Mycobacterium tuberculosis
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	SMITB14
Antibody Type Class	IgG1
Assay System	N\A
Cross Reactivity	SMITB14 bound to whole M. tuberculosis bacteria (H37Rv and Harlingen strains) as well as to the attenuated BCG, but not to other species such as Escherichia coli strains of various O serotypes, Streptococcus pneumoniae isolates, strains of Salmonella, Yersinia enterocolitica and Y. pseudotuberculosis and Nocardia sp.
Proposed Epitope	Arabinomannan portion of the antigen
IEDB Epitope	N/A
Proposed Utility	This antibody might be involved in blocking of mycobacterial invasion. SMITB14 may prevent the uptake of M. tuberculosis through receptor(s) that facilitate bacterial survival and growth.
Curator ID	AA + AS
Date of Curation	03-01-2010
References	PMC1809178

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PolysacDB ID	1011
Carbohydrate Name	Lipoarabinomannan (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Mycobacterium tuberculosis (NCBI Taxonomy) (Drugpedia)
Basic Structure	Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues, and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor
BCSDB Structure	127448
Proposed Function	Reported to suppress T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages. Other reported effects include inhibition of protein kinases, inhibition of the synthesis of mRNA encoding IL-2, IL-5, and granulocyte-macrophage colony stimulating factor (GM-CSF) in human T cells and activation of the complement cascade
Antigenic Nature	Heat killed Mycobacterium tuberculosis
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab lam701
Antibody Type Class	IgG3
Assay System	Sandwich ELISA
Cross Reactivity	This antibody cross-reacted with cross-reacted to a large number of mycobacterial species such as M. tuberculosis, M. bovis, M leprae, M. phlei and M. avium
Proposed Epitope	N\A
IEDB Epitope	N/A
Proposed Utility	These antibodies could be used to detect mycobacterial antigens in sputum
Curator ID	AA + AS
Date of Curation	03-01-2010
References	2127645

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PolysacDB ID	1032
Carbohydrate Name	Lipoarabinomannan (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Mycobacterium leprae (NCBI Taxonomy) (Drugpedia)
Basic Structure	Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor
BCSDB Structure	127448
Proposed Function	T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages
Antigenic Nature	Whole killed mycobacteria leprae cells
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab lam038
Antibody Type Class	IgM
Assay System	Sandwich ELISA
Cross Reactivity	This antibody cross-reacted with cross-reacted to a large number of mycobacterial species such as M. tuberculosis, M. bovis, M leprae, M. phlei and M. avium
Proposed Epitope	N\A
IEDB Epitope	N/A
Proposed Utility	These antibodies could be used to detect mycobacterial antigens in sputum
Curator ID	AA + AS
Date of Curation	09-01-2010
References	2127645

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PolysacDB ID	1033
Carbohydrate Name	Lipoarabinomannan (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Mycobacterium leprae (NCBI Taxonomy) (Drugpedia)
Basic Structure	Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor
BCSDB Structure	127448
Proposed Function	T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages
Antigenic Nature	Whole killed mycobacteria leprae cells
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab lam204
Antibody Type Class	IgM
Assay System	Sandwich ELISA
Cross Reactivity	This antibody cross-reacted with cross-reacted to a large number of mycobacterial species such as M. tuberculosis, M. bovis, M leprae, M. phlei and M. avium
Proposed Epitope	N\A
IEDB Epitope	N/A
Proposed Utility	These antibodies could be used to detect mycobacterial antigens in sputum
Curator ID	AA + AS
Date of Curation	09-01-2010
References	2127645

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PolysacDB ID	1035
Carbohydrate Name	Lipoarabinomannan (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Mycobacterium leprae (NCBI Taxonomy) (Drugpedia)
Basic Structure	Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor
BCSDB Structure	127448
Proposed Function	T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages
Antigenic Nature	Whole killed mycobacteria leprae cells
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab lam603
Antibody Type Class	IgM
Assay System	Sandwich ELISA
Cross Reactivity	This antibody cross-reacted with cross-reacted to a large number of mycobacterial species such as M. tuberculosis, M. bovis, M leprae, M. phlei and M. avium
Proposed Epitope	N\A
IEDB Epitope	N/A
Proposed Utility	These antibodies could be used to detect mycobacterial antigens in sputum
Curator ID	AA + AS
Date of Curation	09-01-2010
References	2127645

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PolysacDB ID	1036
Carbohydrate Name	Lipoarabinomannan (Drugpedia)
Carbohydrate Class	Glycolipid
Microbe Name	Mycobacterium leprae (NCBI Taxonomy) (Drugpedia)
Basic Structure	Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor
BCSDB Structure	127448
Proposed Function	T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages
Antigenic Nature	Whole killed mycobacteria leprae cells
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab Cs-35
Antibody Type Class	IgM
Assay System	Indirect and Competitive ELISA
Cross Reactivity	This antibody cross-reacted to M. tuberculosis and other Mycobacterium speices.
Proposed Epitope	β-D-Araf- (1-->2)-α-D-Araf-(1-->5)-α- D-Araf-(1-->5)-α-D-Araf within the branched hexa-Araf motif of mycobacterial arabinans
IEDB Epitope	76797
Proposed Utility	These antibodies could be used for screening of cell-wall mutants of mycobacteria lacking AG and AraLAM motifs and the recognition of biosynthetic intermediates of cell-wall polysaccharides unique to mycobacteria.
Curator ID	AA + AS
Date of Curation	10-01-2010
References	12368438

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PolysacDB ID	1038
Carbohydrate Name	Lipopolysaccharide (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe Name	Rhizobium leguminosarum (NCBI Taxonomy) (Drugpedia)
Basic Structure	LPS is composed of three parts: (1) lipid A, (2) core polysaccharide, and (3) O antigen. The lipid A region contains two glucosamine sugar derivatives, each with three fatty acids and phosphate or pyrophosphate attached. The core polysaccharide has KDO and attached to lipid A. The side chain O is small polysaccharide chain extending outward from the core, it has several peculiar sugars and varies in composition between bacterial strains.
BCSDB Structure	1686
Proposed Function	LPS is most unusual constituents of outer membrane. It plays important role in host defence avoidance. LPS contributes to the negative charge of the bacterial surface. Lipid A is often toxic and act as endotoxin
Antigenic Nature	Mixture of suspension of cell envelop.
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab 3
Antibody Type Class	N\A
Assay System	Western blotting, spot imunoassays, agglutination tests
Cross Reactivity	This antibody was cross-reactive with different strains of R.leguminosarum like R.biovars viciae, trifolli and phaseoli.
Proposed Epitope	N/A
IEDB Epitope	N/A
Proposed Utility	N\A
Curator ID	AA + AS
Date of Curation	10-01-2010
References	PMC209711

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PolysacDB ID	1040
Carbohydrate Name	Lipopolysaccharide (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe Name	Chlamydia spp. (NCBI Taxonomy) (Drugpedia)
Basic Structure	LPS is composed of three parts: (1) lipid A, (2) core polysaccharide, and (3) O antigen. The lipid A region contains two glucosamine sugar derivatives, each with three fatty acids and phosphate or pyrophosphate attached. The core polysaccharide has KDO and attached to lipid A. The side chain O is small polysaccharide chain extending outward from the core, it has several peculiar sugars and varies in composition between bacterial strains.
BCSDB Structure	116693
Proposed Function	LPS is most unusual constituents of outer membrane. It plays important role in host defence avoidance. LPS contributes to the negative charge of the bacterial surface. Lipid A is often toxic and act as endotoxin
Antigenic Nature	Formalin killed L2 EBs
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab L21-6
Antibody Type Class	IgG3
Assay System	Immunobloting
Cross Reactivity	This antibody was cross-reactive with Re LPS of S.typhimurium.
Proposed Epitope	N/A
IEDB Epitope	N/A
Proposed Utility	Monoclonal antibody L21-6 recognizes chlamydal genus specific epitope.
Curator ID	AA + AS
Date of Curation	12-01-2010
References	PMC263518

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PolysacDB ID	1041
Carbohydrate Name	Phosphocholine (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe Name	Pneumococcal strain WU(12) (NCBI Taxonomy) (Drugpedia)
Basic Structure	Phosphocholine (PC) is an intermediate in the synthesis of phosphatidylcholine in tissues. Phosphocholine is made in a reaction, catalyzed by choline kinase, that converts ATP + Choline into Phosphocholine and ADP
BCSDB Structure	N/A
Proposed Function	Phosphocholine is determinant of lipotechoic acids of Gram positive bacteria
Antigenic Nature	Cell extract and heat killed Pneumococcal strain EF3296.
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	SR4W1
Antibody Type Class	IgG2a
Assay System	Blood bactericidal assay, hemolytic activity
Cross Reactivity	N/A
Proposed Epitope	Phosphocholine
IEDB Epitope	N/A
Proposed Utility	Monoclonal antibody SR4W1 can protect mice against Pneumococcal infections.
Curator ID	AA + AS
Date of Curation	12-01-2010
References	PMC313299

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PolysacDB ID	1042
Carbohydrate Name	Glucan (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe Name	Neurospora crassa (NCBI Taxonomy) (Drugpedia)
Basic Structure	Glucans are a heterogeneous group of glucose polymers, consisting of a backbone of β(1-->3)-linked β-D-glucopyranosyl units with β(1-->6)-linked side chains of varying distribution and length
BCSDB Structure	N/A
Proposed Function	Activates leukocytes, stimulating their phagocytic, cytotoxic, and antimicrobial activities, including the production of reactive oxygen and nitrogen intermediates
Antigenic Nature	Homogenous suspension of hyphal walls.
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	S4D1
Antibody Type Class	IgM
Assay System	ELISA, immunofluorescence
Cross Reactivity	This antibody was cross-reactive with A.nidulans, Schiz.commune.
Proposed Epitope	1,3-α-glucan
IEDB Epitope	N/A
Proposed Utility	Screening of fungi for presence of 1,3-α-glucan in hyphae cell wall.
Curator ID	AA + AS
Date of Curation	13-01-2010
References	9245814

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PolysacDB ID	1045
Carbohydrate Name	Lipopolysaccharide (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe Name	Salmonella typhimurium SR-11 (NCBI Taxonomy) (Drugpedia)
Basic Structure	LPS is composed of three parts: (1) lipid A, (2) core polysaccharide, and (3) O antigen. The lipid A region contains two glucosamine sugar derivatives, each with three fatty acids and phosphate or pyrophosphate attached. The core polysaccharide has KDO and attached to lipid A. The side chain O is small polysaccharide chain extending outward from the core, it has several peculiar sugars and varies in composition between bacterial strains.
BCSDB Structure	N/A
Proposed Function	LPS is most unusual constituents of outer membrane. It plays important role in host defence avoidance. LPS contributes to the negative charge of the bacterial surface. Lipid A is often toxic and act as endotoxin
Antigenic Nature	Live S.typhimurium SR cells.
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	ST-1
Antibody Type Class	IgM
Assay System	ELISA Hemaggluttination assay
Cross Reactivity	This antibody was cross-reactive with Salmonella typhimurium LT-2, Salmonella typhimurium derby.
Proposed Epitope	O-polysaccharide
IEDB Epitope	N/A
Proposed Utility	This antibody can be used in serological assays to detect the desired antigen.
Curator ID	AA + AS
Date of Curation	13-01-2010
References	6203984

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PolysacDB ID	1046
Carbohydrate Name	Lipopolysaccharide (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe Name	Salmonella typhimurium SR-11 (NCBI Taxonomy) (Drugpedia)
Basic Structure	LPS is composed of three parts: (1) lipid A, (2) core polysaccharide, and (3) O antigen. The lipid A region contains two glucosamine sugar derivatives, each with three fatty acids and phosphate or pyrophosphate attached. The core polysaccharide has KDO and attached to lipid A. The side chain O is small polysaccharide chain extending outward from the core, it has several peculiar sugars and varies in composition between bacterial strains.
BCSDB Structure	N/A
Proposed Function	LPS is most unusual constituents of outer membrane. It plays important role in host defence avoidance. LPS contributes to the negative charge of the bacterial surface. Lipid A is often toxic and act as endotoxin
Antigenic Nature	Live S.typhimurium SR cells.
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Polysera
Antibody Type Class	IgG
Assay System	ELISA Hemaggluttination assay
Cross Reactivity	This antibody was cross-reactive with Salmonella typhimurium LT-2, Salmonella typhimurium derby. Salmonella typhimurium dublin, Salmonella enteritidis and Salmonella paratyphi A.
Proposed Epitope	O-polysaccharide
IEDB Epitope	N/A
Proposed Utility	This antibody can be used in serological assays to detect the desired antigen.
Curator ID	AA + AS
Date of Curation	14-01-2010
References	6203984

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PolysacDB ID	1047
Carbohydrate Name	Lipopolysaccharide (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe Name	Escherichia coli strain J5 (chemotype Rc) (NCBI Taxonomy) (Drugpedia)
Basic Structure	The core oligosaccharide part of the LPS consists of the following residues : α-D-Glcp(1-->2)α-D-Glcp(1-->2)α-D-Glcp [branched to α-D-GlcpNAc(1-->3)] (1-->3)α-L-D-man-Hepp [branched to α-D-GlcpNAc(1-->7)α-L-D-man-Hepp(1-->7)] and [branched to a phosphate group] (1-->3)α-L-D-man-Hepp [branched to α-Kdop(2-->4)α-Kdop(2-->4)α-Kdop(2-6)Subst] and [branched to a phosphate group](1-->5)
BCSDB Structure	N/A
Proposed Function	N/A
Antigenic Nature	Whole cells
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab 7
Antibody Type Class	IgG3
Assay System	ELISA, Limulus assay, invivo protection assay
Cross Reactivity	This antibody was specific to E. coli J5
Proposed Epitope	Terminal glucose residues
IEDB Epitope	N/A
Proposed Utility	N/A
Curator ID	AA + AS
Date of Curation	14-01-2010
References	2455054

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PolysacDB ID	1048
Carbohydrate Name	Lipopolysaccharide (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe Name	Escherichia coli strain J5 (chemotype Rc) (NCBI Taxonomy) (Drugpedia)
Basic Structure	The core oligosaccharide part of the LPS consists of the following residues : α-D-Glcp(1-->2)α-D-Glcp(1-->2)α-D-Glcp [branched to α-D-GlcpNAc(1-->3)] (1-->3)α-L-D-man-Hepp [branched to α-D-GlcpNAc(1-->7)α-L-D-man-Hepp(1-->7)] and [branched to a phosphate group] (1-->3)α-L-D-man-Hepp [branched to α-Kdop(2-->4)α-Kdop(2-->4)α-Kdop(2-6)Subst] and [branched to a phosphate group](1-->5)
BCSDB Structure	N/A
Proposed Function	N/A
Antigenic Nature	Whole cells
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab 10
Antibody Type Class	IgG3
Assay System	ELISA, Limulus assay, invivo protection assay
Cross Reactivity	This antibody was specific to E. coli J5
Proposed Epitope	Terminal glucose residues
IEDB Epitope	N/A
Proposed Utility	N/A
Curator ID	AA + AS
Date of Curation	15-01-2010
References	2455054

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PolysacDB ID	1049
Carbohydrate Name	Lipopolysaccharide (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe Name	Escherichia coli strain J5 (chemotype Rc) (NCBI Taxonomy) (Drugpedia)
Basic Structure	The core oligosaccharide part of the LPS consists of the following residues : α-D-Glcp(1-->2)α-D-Glcp(1-->2)α-D-Glcp [branched to α-D-GlcpNAc(1-->3)] (1-->3)α-L-D-man-Hepp [branched to α-D-GlcpNAc(1-->7)α-L-D-man-Hepp(1-->7)] and [branched to a phosphate group] (1-->3)α-L-D-man-Hepp [branched to α-Kdop(2-->4)α-Kdop(2-->4)α-Kdop(2-6)Subst] and [branched to a phosphate group](1-->5)
BCSDB Structure	N/A
Proposed Function	N/A
Antigenic Nature	Whole cells
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab 2
Antibody Type Class	IgG1
Assay System	ELISA, Limulus assay, invivo protection assay
Cross Reactivity	This antibody ross-reacted with Salmonella minnesota strain R5
Proposed Epitope	Terminal glucose residues
IEDB Epitope	N/A
Proposed Utility	N/A
Curator ID	AA + AS
Date of Curation	15-01-2010
References	2455054

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PolysacDB ID	1050
Carbohydrate Name	Lipopolysaccharide (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe Name	Escherichia coli strain J5 (chemotype Rc) (NCBI Taxonomy) (Drugpedia)
Basic Structure	The core oligosaccharide part of the LPS consists of the following residues : α-D-Glcp(1-->2)α-D-Glcp(1-->2)α-D-Glcp [branched to α-D-GlcpNAc(1-->3)] (1-->3)α-L-D-man-Hepp [branched to α-D-GlcpNAc(1-->7)α-L-D-man-Hepp(1-->7)] and [branched to a phosphate group] (1-->3)α-L-D-man-Hepp [branched to α-Kdop(2-->4)α-Kdop(2-->4)α-Kdop(2-6)Subst] and [branched to a phosphate group](1-->5)
BCSDB Structure	N/A
Proposed Function	N/A
Antigenic Nature	Whole cells
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab 4
Antibody Type Class	IgG2a
Assay System	ELISA, Limulus assay, invivo protection assay
Cross Reactivity	This antibody ross-reacted with Salmonella minnesota strain R5
Proposed Epitope	Terminal glucose residues
IEDB Epitope	N/A
Proposed Utility	N/A
Curator ID	AA + AS
Date of Curation	16-01-2010
References	2455054

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PolysacDB ID	1051
Carbohydrate Name	Lipopolysaccharide (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe Name	Escherichia coli strain J5 (chemotype Rc) (NCBI Taxonomy) (Drugpedia)
Basic Structure	The core oligosaccharide part of the LPS consists of the following residues : α-D-Glcp(1-->2)α-D-Glcp(1-->2)α-D-Glcp [branched to α-D-GlcpNAc(1-->3)] (1-->3)α-L-D-man-Hepp [branched to α-D-GlcpNAc(1-->7)α-L-D-man-Hepp(1-->7)] and [branched to a phosphate group] (1-->3)α-L-D-man-Hepp [branched to α-Kdop(2-->4)α-Kdop(2-->4)α-Kdop(2-6)Subst] and [branched to a phosphate group](1-->5)
BCSDB Structure	N/A
Proposed Function	N/A
Antigenic Nature	Whole cells
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab 5
Antibody Type Class	IgG1
Assay System	ELISA, Limulus assay, invivo protection assay
Cross Reactivity	This antibody ross-reacted with Salmonella minnesota strain R5
Proposed Epitope	Terminal glucose residues
IEDB Epitope	N/A
Proposed Utility	N/A
Curator ID	AA + AS
Date of Curation	16-01-2010
References	2455054

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PolysacDB ID	1052
Carbohydrate Name	Lipopolysaccharide (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe Name	Escherichia coli strain J5 (chemotype Rc) (NCBI Taxonomy) (Drugpedia)
Basic Structure	The core oligosaccharide part of the LPS consists of the following residues : α-D-Glcp(1-->2)α-D-Glcp(1-->2)α-D-Glcp [branched to α-D-GlcpNAc(1-->3)] (1-->3)α-L-D-man-Hepp [branched to α-D-GlcpNAc(1-->7)α-L-D-man-Hepp(1-->7)] and [branched to a phosphate group] (1-->3)α-L-D-man-Hepp [branched to α-Kdop(2-->4)α-Kdop(2-->4)α-Kdop(2-6)Subst] and [branched to a phosphate group](1-->5)
BCSDB Structure	N/A
Proposed Function	N/A
Antigenic Nature	Whole cells
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab 3
Antibody Type Class	IgG3
Assay System	ELISA, Limulus assay, invivo protection assay
Cross Reactivity	This antibody ross-reacted with Salmonella minnesota strain R5
Proposed Epitope	Terminal glucose residues
IEDB Epitope	N/A
Proposed Utility	N/A
Curator ID	AA + AS
Date of Curation	16-01-2010
References	2455054

Record - 22 of 1335 [TOP]

PolysacDB ID	1053
Carbohydrate Name	Lipopolysaccharide (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe Name	Escherichia coli strain J5 (chemotype Rc) (NCBI Taxonomy) (Drugpedia)
Basic Structure	The core oligosaccharide part of the LPS consists of the following residues : α-D-Glcp(1-->2)α-D-Glcp(1-->2)α-D-Glcp [branched to α-D-GlcpNAc(1-->3)] (1-->3)α-L-D-man-Hepp [branched to α-D-GlcpNAc(1-->7)α-L-D-man-Hepp(1-->7)] and [branched to a phosphate group] (1-->3)α-L-D-man-Hepp [branched to α-Kdop(2-->4)α-Kdop(2-->4)α-Kdop(2-6)Subst] and [branched to a phosphate group](1-->5)
BCSDB Structure	N/A
Proposed Function	N/A
Antigenic Nature	Whole cells
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab 11
Antibody Type Class	IgG3
Assay System	ELISA, Limulus assay, invivo protection assay
Cross Reactivity	This antibody ross-reacted with Salmonella minnesota strain R5
Proposed Epitope	Terminal glucose residues
IEDB Epitope	N/A
Proposed Utility	N/A
Curator ID	AA + AS
Date of Curation	16-01-2010
References	2455054

Record - 23 of 1335 [TOP]

PolysacDB ID	1054
Carbohydrate Name	Lipopolysaccharide (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe Name	Escherichia coli strain J5 (chemotype Rc) (NCBI Taxonomy) (Drugpedia)
Basic Structure	The core oligosaccharide part of the LPS consists of the following residues : α-D-Glcp(1-->2)α-D-Glcp(1-->2)α-D-Glcp [branched to α-D-GlcpNAc(1-->3)] (1-->3)α-L-D-man-Hepp [branched to α-D-GlcpNAc(1-->7)α-L-D-man-Hepp(1-->7)] and [branched to a phosphate group] (1-->3)α-L-D-man-Hepp [branched to α-Kdop(2-->4)α-Kdop(2-->4)α-Kdop(2-6)Subst] and [branched to a phosphate group](1-->5)
BCSDB Structure	N/A
Proposed Function	N/A
Antigenic Nature	Whole cells
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab 8
Antibody Type Class	IgG3
Assay System	ELISA, Limulus assay, invivo protection assay
Cross Reactivity	This antibody ross-reacted with Salmonella minnesota strain R5
Proposed Epitope	Terminal glucose residues
IEDB Epitope	N/A
Proposed Utility	N/A
Curator ID	AA + AS
Date of Curation	16-01-2010
References	2455054

Record - 24 of 1335 [TOP]

PolysacDB ID	1055
Carbohydrate Name	Lipopolysaccharide (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe Name	Escherichia coli strain J5 (chemotype Rc) (NCBI Taxonomy) (Drugpedia)
Basic Structure	The core oligosaccharide part of the LPS consists of the following residues : α-D-Glcp(1-->2)α-D-Glcp(1-->2)α-D-Glcp [branched to α-D-GlcpNAc(1-->3)] (1-->3)α-L-D-man-Hepp [branched to α-D-GlcpNAc(1-->7)α-L-D-man-Hepp(1-->7)] and [branched to a phosphate group] (1-->3)α-L-D-man-Hepp [branched to α-Kdop(2-->4)α-Kdop(2-->4)α-Kdop(2-6)Subst] and [branched to a phosphate group](1-->5)
BCSDB Structure	N/A
Proposed Function	N/A
Antigenic Nature	Whole cells
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab 9
Antibody Type Class	IgG3
Assay System	ELISA, Limulus assay, invivo protection assay
Cross Reactivity	This antibody ross-reacted with Salmonella minnesota strain R5
Proposed Epitope	Terminal glucose residues
IEDB Epitope	N/A
Proposed Utility	N/A
Curator ID	AA + AS
Date of Curation	16-01-2010
References	2455054

Record - 25 of 1335 [TOP]

PolysacDB ID	1056
Carbohydrate Name	Lipopolysaccharide (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe Name	Escherichia coli strain J5 (chemotype Rc) (NCBI Taxonomy) (Drugpedia)
Basic Structure	The core oligosaccharide part of the LPS consists of the following residues : α-D-Glcp(1-->2)α-D-Glcp(1-->2)α-D-Glcp [branched to α-D-GlcpNAc(1-->3)] (1-->3)α-L-D-man-Hepp [branched to α-D-GlcpNAc(1-->7)α-L-D-man-Hepp(1-->7)] and [branched to a phosphate group] (1-->3)α-L-D-man-Hepp [branched to α-Kdop(2-->4)α-Kdop(2-->4)α-Kdop(2-6)Subst] and [branched to a phosphate group](1-->5)
BCSDB Structure	N/A
Proposed Function	N/A
Antigenic Nature	Whole cells
Carrier Name	Nil
Conjugate Method	Nil
Antibodies	Mab 13
Antibody Type Class	IgG3
Assay System	ELISA, Limulus assay, invivo protection assay
Cross Reactivity	This antibody ross-reacted with Salmonella minnesota strain R5
Proposed Epitope	Terminal glucose residues
IEDB Epitope	N/A
Proposed Utility	N/A
Curator ID	AA + AS
Date of Curation	16-01-2010
References	2455054

Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020