PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
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PolysacDB ID1004
Carbohydrate NameCapsular polysaccharide   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
Microbe NameHaemophilus influenzae type B   (NCBI Taxonomy)   (Drugpedia)
Basic StructureA relatively simple antigen consisting of repeating units of 3-β-D ribose-(1-->1)-D-ribitol-5-phosphate
BCSDB Structure23423
Proposed FunctionAn important virulence determinant
Antigenic NatureGlycoconjugates
Carrier NameNeisseria meningitidis group B outer membrane protein complex (Hib PS-OMP)
Conjugate MethodThe strategy uses a oligopeptide spacer molecule whose parts are derived from both modified Haemophilus influenzae capsular polysaccharide and Neisseria meningitides group B outer membrane complex
AntibodiesPolysera
Antibody Type ClassIgG1 and IgG2
Assay SystemN\A
Cross ReactivityN/A
Proposed EpitopeN\A
IEDB EpitopeN/A
Proposed UtilityThese antibodies exert their protective effect by initiating complement-mediated activities including opsonization and bacterial lysis
Curator IDAA + AS
Date of Curation01-01-2010
ReferencesPMC296547

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