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| PolysacDB ID | 1990 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Streptococcus pneumoniae serotype 6B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | The capsular polysaccharide consists of the following residues : -2)-α-D-Galp-(1-->3)-α-D-Glcp-(1-->3)-α-L-Rhap-(1-->4)-D-Rib-ol-(5-P- |
| BCSDB Structure | 5205 |
| Proposed Function | N/A |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Keyhole limpet hemocyanin |
| Conjugate Method | N/A |
| Antibodies | Mab Hyp6BM6 |
| Antibody Type Class | IgM |
| Assay System | Sandwich ELISA, opsonization assays |
| Cross Reactivity | This Mab cross-reacted with strain 6A |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab had opsonophagocytic activity |
| Curator ID | AA + AS |
| Date of Curation | 12-12-2010 |
| References | PMC97888 |
| PolysacDB ID | 1991 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Streptococcus pneumoniae serotype 6B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | The capsular polysaccharide consists of the following residues : -2)-α-D-Galp-(1-->3)-α-D-Glcp-(1-->3)-α-L-Rhap-(1-->4)-D-Rib-ol-(5-P- |
| BCSDB Structure | 5205 |
| Proposed Function | N/A |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Keyhole limpet hemocyanin |
| Conjugate Method | N/A |
| Antibodies | Mab Hyp6BM7 |
| Antibody Type Class | IgM |
| Assay System | Sandwich ELISA, opsonization assays |
| Cross Reactivity | This Mab was specific to strain 6B and did not cross-react with strain 6A |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | N/A |
| Curator ID | AA + AS |
| Date of Curation | 12-12-2010 |
| References | PMC97888 |
| PolysacDB ID | 1992 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Streptococcus pneumoniae serotype 6B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | The capsular polysaccharide consists of the following residues : -2)-α-D-Galp-(1-->3)-α-D-Glcp-(1-->3)-α-L-Rhap-(1-->4)-D-Rib-ol-(5-P- |
| BCSDB Structure | 5205 |
| Proposed Function | N/A |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Keyhole limpet hemocyanin |
| Conjugate Method | N/A |
| Antibodies | Mab Hyp6BM8 |
| Antibody Type Class | IgM |
| Assay System | Sandwich ELISA, opsonization assays |
| Cross Reactivity | This Mab cross-reacted with strain 6A |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab had opsonophagocytic activity |
| Curator ID | AA + AS |
| Date of Curation | 13-12-2010 |
| References | PMC97888 |
| PolysacDB ID | 1993 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Streptococcus pneumoniae serotype 6B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | The capsular polysaccharide consists of the following residues : -2)-α-D-Galp-(1-->3)-α-D-Glcp-(1-->3)-α-L-Rhap-(1-->4)-D-Rib-ol-(5-P- |
| BCSDB Structure | 5205 |
| Proposed Function | N/A |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Keyhole limpet hemocyanin |
| Conjugate Method | N/A |
| Antibodies | Mab Hyp6BM9 |
| Antibody Type Class | IgM |
| Assay System | Sandwich ELISA, opsonization assays |
| Cross Reactivity | This Mab cross-reacted with strain 6A |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab had opsonophagocytic activity |
| Curator ID | AA + AS |
| Date of Curation | 13-12-2010 |
| References | PMC97888 |
| PolysacDB ID | 1994 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Streptococcus pneumoniae serotype 6B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | The capsular polysaccharide consists of the following residues : -2)-α-D-Galp-(1-->3)-α-D-Glcp-(1-->3)-α-L-Rhap-(1-->4)-D-Rib-ol-(5-P- |
| BCSDB Structure | 5205 |
| Proposed Function | N/A |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Keyhole limpet hemocyanin |
| Conjugate Method | N/A |
| Antibodies | Mab Hyp6BM10 |
| Antibody Type Class | IgM |
| Assay System | Sandwich ELISA, opsonization assays |
| Cross Reactivity | This Mab cross-reacted with strain 6A |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab had opsonophagocytic activity |
| Curator ID | AA + AS |
| Date of Curation | 13-12-2010 |
| References | PMC97888 |
| PolysacDB ID | 1999 |
| Carbohydrate Name | Disaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Streptococcus pneumoniae serotype 6B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | The structure of the disaccharide is α-L-Rhap-(1-->4)-D-Rib-ol-[5-->P-->(CH2)3NH2] |
| BCSDB Structure | 5205 |
| Proposed Function | N/A |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Keyhole limpet hemocyanin |
| Conjugate Method | The saccharides were coupled via the 3-aminopropyl spacer to carrier protein KLH in a stepwise reaction: the amino-terminal groups of the OS fragment and KLH were activated by S acetylation and Br acetylation, respectively, and coupled via a thioether linkage |
| Antibodies | Antisera |
| Antibody Type Class | N/A |
| Assay System | ELISA, phagocytosis assays and protection experiments |
| Cross Reactivity | This antisera was specific to capsular polysaccharide of strain 6B and did not cross-react with 6A strains |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This antisera could passively protect mice against a 6B challenge |
| Curator ID | AA + AS |
| Date of Curation | 14-12-2010 |
| References | PMC97953 |
| PolysacDB ID | 2000 |
| Carbohydrate Name | Trisaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Streptococcus pneumoniae serotype 6B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | The structure of the trisaccharide is -D-Rib-ol-(5-->P-->2)-α-D-Galp-(1-->3)-α-D-Glcp-[1-->O(CH2)3NH2] |
| BCSDB Structure | 5205 |
| Proposed Function | N/A |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Keyhole limpet hemocyanin |
| Conjugate Method | The saccharides were coupled via the 3-aminopropyl spacer to carrier protein KLH in a stepwise reaction: the amino-terminal groups of the OS fragment and KLH were activated by S acetylation and Br acetylation, respectively, and coupled via a thioether linkage |
| Antibodies | Antisera |
| Antibody Type Class | N/A |
| Assay System | ELISA, phagocytosis assays and protection experiments |
| Cross Reactivity | This antisera was specific to capsular polysaccharide of strain 6B and did not cross-react with 6A strains |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This antisera could passively protect mice against a 6B challenge |
| Curator ID | AA + AS |
| Date of Curation | 14-12-2010 |
| References | PMC97953 |
| PolysacDB ID | 2001 |
| Carbohydrate Name | Tetrasaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Streptococcus pneumoniae serotype 6B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | The structure of the trisaccharide is α-L-Rhap-(1-->4)-D-Rib-ol-(5-->P-->2)-α-D-Galp-(1-->3)-α-D-Glcp-[1-->O(CH2)3NH2] |
| BCSDB Structure | N/A |
| Proposed Function | N/A |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Keyhole limpet hemocyanin |
| Conjugate Method | The saccharides were coupled via the 3-aminopropyl spacer to carrier protein KLH in a stepwise reaction: the amino-terminal groups of the OS fragment and KLH were activated by S acetylation and Br acetylation, respectively, and coupled via a thioether linkage |
| Antibodies | Antisera |
| Antibody Type Class | N/A |
| Assay System | ELISA, phagocytosis assays and protection experiments |
| Cross Reactivity | This antisera cross-reacted with capsular polysaccharide of 6A strains |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This antisera could passively protect mice against a 6B and 6A challenge |
| Curator ID | AA + AS |
| Date of Curation | 14-12-2010 |
| References | PMC97953 |
| PolysacDB ID | 2605 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Cryptococcus neoformans Serotype D (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | The capsular polysaccharide has a linear α-(1-->3)-linked mannose backbone that is substituted with nonreducing D-xylosyl and D-glucuronosyl acid groups. The mannose backbone is partially O-acetylated |
| BCSDB Structure | 136943 |
| Proposed Function | The capsular polysaccharide is an important virulence factor |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Keyhole limpet hemocyanin |
| Conjugate Method | Forty milligrams of crude polysaccharide was dissolved in 4 ml of physiological saline solution (PSS). One milliliter of 1% cyanuric chloride in dimethylformamide was added to the polysaccharide solution and stirred for 1 h at 48°C. KLH in PSS (100 mg/2ml) was added and stirred for 1 h at 258°C, and the solution was then incubated at 48C for 18 h. The solution was dialyzed against water for 30 h and centrifuged. The protein concentration in the supernatant was adjusted to 2 mg/ml, 1/9 volume of 10% aluminum potassium sulfate solution was added, and the pH was adjusted to 6.5 with 10% sodium carbonate. The precipitated antigen was removed by centrifugation and resuspended in PSS |
| Antibodies | Mab CRND8 |
| Antibody Type Class | IgM |
| Assay System | ELISA and CSA[Cell Slide Agglutination] |
| Cross Reactivity | This antibody cross-reacted with Serotype A and D serotypes |
| Proposed Epitope | O-acetylated glucurunoxylomannan |
| IEDB Epitope | N/A |
| Proposed Utility | Used to differentiate various strains of all serotypes |
| Curator ID | AA + AS |
| Date of Curation | 16-07-2011 |
| References | PMC170253 |
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Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020 |