PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 2

Entry No. - 1   [TOP]
PolysacDB ID1973
Carbohydrate NameCapsular polysaccharide   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
MicrobeStreptococcus pneumoniae strain 14   (NCBI Taxonomy)   (Drugpedia)
Basic StructureThe capsular polysaccharide consists of the following residues : -6)-β-D-GlcpNAc [branched to β-D-Galp-(1-->4)] -(1-->3)-β-D-Galp-(1-->4)-β-D-Glcp-(1-
BCSDB Structure2848
Proposed functionsN/A
Antigenic Nature used to produce antibodiesGlycoconjugates
Carrier NameTetanus toxoid
Conjugation MethodThe oligosaccharide was derivatized with adipic acid dihydrazide and coupled to tetanus toxoid
AntibodiesMab 1F6
Antibody type and classIgG1
Assay SystemEnzyme Inhibition Assay, colony blotting, Opsonophagocytosis assay
Cross-reactivityThis Mab was specific tgo strain 14 and did not cross-react with other strains
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityN/A
Curator IDAA + AS
Date of Curation08-12-2010
ReferencesPMC95896


Entry No. - 2   [TOP]
PolysacDB ID1974
Carbohydrate NameCapsular polysaccharide   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
MicrobeStreptococcus pneumoniae strain 14   (NCBI Taxonomy)   (Drugpedia)
Basic StructureThe capsular polysaccharide consists of the following residues : -6)-β-D-GlcpNAc [branched to β-D-Galp-(1-->4)] -(1-->3)-β-D-Galp-(1-->4)-β-D-Glcp-(1-
BCSDB Structure2848
Proposed functionsN/A
Antigenic Nature used to produce antibodiesGlycoconjugates
Carrier NameTetanus toxoid
Conjugation MethodThe oligosaccharide was derivatized with adipic acid dihydrazide and coupled to tetanus toxoid
AntibodiesMab 1F2
Antibody type and classIgG1
Assay SystemEnzyme Inhibition Assay, colony blotting, Opsonophagocytosis assay
Cross-reactivityThis Mab was specific tgo strain 14 and did not cross-react with other strains
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityN/A
Curator IDAA + AS
Date of Curation08-12-2010
ReferencesPMC95896


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