|
|
|
|
Home | Search | Advance Search | Browse | Online Submission | Documentation & FAQ | Team | Contact us |
|
| PolysacDB ID | 2400 |
| Carbohydrate Name | Lipoteichoic acids (LTAs) (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Streptococcus mutans Ingbritt (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | LTAs are amphiphiles composed of a membrane lipid or glycolipid which is covalently linked to a linear chain of 15 to 30 polyglycerophosphate (PGP) units |
| BCSDB Structure | N/A |
| Proposed functions | Lipoteichoic acids (LTAs) are present on the surfaces of a majority of gram-positive bacteria and have been shown to constitute 1 to 2% of the dry weight of several organisms |
| Antigenic Nature used to produce antibodies | Ethylene oxide killed cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab 2B5 |
| Antibody type and class | IgG1 |
| Assay System | Haemagglutination |
| Cross-reactivity | This Mab cross-reacted with LTA from L.casei 6375 but was relatively less efficient in its ability to interact with the LTAs of L. fermentum and S. faecium |
| Proposed epitopes | Glycerophosphate-glycerophosphateglycerol residue backbone seemed to be an important part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | These highly specific reagents [Mabs] should prove useful not only for affinity purification of LTAs but also for experiments designed to define the putative role(s) of LTAs in biological processes |
| Curator ID | AA + AS |
| Date of Curation | 01-05-2011 |
| References | PMC264251 |
| PolysacDB ID | 2401 |
| Carbohydrate Name | Lipoteichoic acids (LTAs) (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Streptococcus mutans Ingbritt (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | LTAs are amphiphiles composed of a membrane lipid or glycolipid which is covalently linked to a linear chain of 15 to 30 polyglycerophosphate (PGP) units |
| BCSDB Structure | N/A |
| Proposed functions | Lipoteichoic acids (LTAs) are present on the surfaces of a majority of gram-positive bacteria and have been shown to constitute 1 to 2% of the dry weight of several organisms |
| Antigenic Nature used to produce antibodies | Ethylene oxide killed cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab 7B11 |
| Antibody type and class | IgG3 |
| Assay System | Haemagglutination |
| Cross-reactivity | This Mab cross-reacted with LTA from L.casei 6375 and L. fermentum but was relatively less efficient in its ability to interact with the LTAs of S. faecium |
| Proposed epitopes | Glycerophosphate-glycerophosphateglycerol residue backbone seemed to be an important part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | These highly specific reagents [Mabs] should prove useful not only for affinity purification of LTAs but also for experiments designed to define the putative role(s) of LTAs in biological processes |
| Curator ID | AA + AS |
| Date of Curation | 01-05-2011 |
| References | PMC264251 |
|
Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020 |