PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613

Total Entries - 5
Entry No. - 1 [TOP]

PolysacDB ID	2294
Carbohydrate Name	Core oligosaccharide (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe	Shigella spp. (NCBI Taxonomy) (Drugpedia)
Basic Structure	LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The O-antigen consists of the following residues : -3)-β-D-Quip4NAc-(1-->2)-α-D-Manp [branched to α-L-Rhap-(1-->3)] -(1-->4)-β-D-Galp-(1-->3)-α-D-GlcpNAc-(1-
BCSDB Structure	N/A
Proposed functions	LPS plays an important virulence role based on its antiphagocytic and endotoxic properties
Antigenic Nature used to produce antibodies	Heat killed cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 2C32E6
Antibody type and class	N/A
Assay System	Indirect ELISA
Cross-reactivity	This Mab was reactive to S. flexneri and S. boydii
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab has potential importance in immunological detection of Shigella from unknown samples
Curator ID	AA + AS
Date of Curation	23-03-2011
References	11394534

Entry No. - 2 [TOP]

PolysacDB ID	2295
Carbohydrate Name	Core oligosaccharide (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe	Shigella spp. (NCBI Taxonomy) (Drugpedia)
Basic Structure	LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The O-antigen consists of the following residues : -3)-β-D-Quip4NAc-(1-->2)-α-D-Manp [branched to α-L-Rhap-(1-->3)] -(1-->4)-β-D-Galp-(1-->3)-α-D-GlcpNAc-(1-
BCSDB Structure	N/A
Proposed functions	LPS plays an important virulence role based on its antiphagocytic and endotoxic properties
Antigenic Nature used to produce antibodies	Heat killed cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 4D64B9
Antibody type and class	N/A
Assay System	Indirect ELISA
Cross-reactivity	This Mab was reactive to S. flexneri and S. boydii
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab has potential importance in immunological detection of Shigella from unknown samples
Curator ID	AA + AS
Date of Curation	23-03-2011
References	11394534

Entry No. - 3 [TOP]

PolysacDB ID	2296
Carbohydrate Name	Core oligosaccharide (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe	Shigella spp. (NCBI Taxonomy) (Drugpedia)
Basic Structure	LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The O-antigen consists of the following residues : -3)-β-D-Quip4NAc-(1-->2)-α-D-Manp [branched to α-L-Rhap-(1-->3)] -(1-->4)-β-D-Galp-(1-->3)-α-D-GlcpNAc-(1-
BCSDB Structure	N/A
Proposed functions	LPS plays an important virulence role based on its antiphagocytic and endotoxic properties
Antigenic Nature used to produce antibodies	Heat killed cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 5E45D8
Antibody type and class	N/A
Assay System	Indirect ELISA
Cross-reactivity	This Mab was specific to S. flexneri
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab has potential importance in immunological detection of Shigella from unknown samples
Curator ID	AA + AS
Date of Curation	24-03-2011
References	11394534

Entry No. - 4 [TOP]

PolysacDB ID	2297
Carbohydrate Name	Core oligosaccharide (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe	Shigella spp. (NCBI Taxonomy) (Drugpedia)
Basic Structure	LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The O-antigen consists of the following residues : -3)-β-D-Quip4NAc-(1-->2)-α-D-Manp [branched to α-L-Rhap-(1-->3)] -(1-->4)-β-D-Galp-(1-->3)-α-D-GlcpNAc-(1-
BCSDB Structure	N/A
Proposed functions	LPS plays an important virulence role based on its antiphagocytic and endotoxic properties
Antigenic Nature used to produce antibodies	Heat killed cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 4B33D10
Antibody type and class	N/A
Assay System	Indirect ELISA
Cross-reactivity	This Mab cross-reacted with all Shigella species
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab has potential importance in immunological detection of Shigella from unknown samples
Curator ID	AA + AS
Date of Curation	25-03-2011
References	11394534

Entry No. - 5 [TOP]

PolysacDB ID	2298
Carbohydrate Name	Core oligosaccharide (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe	Shigella spp. (NCBI Taxonomy) (Drugpedia)
Basic Structure	LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The O-antigen consists of the following residues : -3)-β-D-Quip4NAc-(1-->2)-α-D-Manp [branched to α-L-Rhap-(1-->3)] -(1-->4)-β-D-Galp-(1-->3)-α-D-GlcpNAc-(1-
BCSDB Structure	N/A
Proposed functions	LPS plays an important virulence role based on its antiphagocytic and endotoxic properties
Antigenic Nature used to produce antibodies	Heat killed cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 1B52F10
Antibody type and class	N/A
Assay System	Indirect ELISA
Cross-reactivity	This Mab cross-reacted with all Shigella species
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab has potential importance in immunological detection of Shigella from unknown samples
Curator ID	AA + AS
Date of Curation	25-03-2011
References	11394534

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