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| PolysacDB ID | 2314 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Shigella flexneri serotype 2b (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Chemically, the O-antigen is a polysaccharide chain of variable length, built up by repetitive sequences of tetra- to hexasaccharides. It consists of a basic tetrasaccharide repeating unit consisting of three rhamnoses and one N-acetylglucosamine was common to all S. flexneri strains (except serotype 17): -2)-α-L-Rhap-[branched to α-D-Glcp(1-->4)](1-->2)-α-L-Rhap-(1-->3)-α-L-Rhap-[branched to α-D-Glcp(1-->3)](1-->3)-β-D-GlcpNAc-(1--> |
| BCSDB Structure | 108645 |
| Proposed functions | LPS plays an important virulence role based on its antiphagocytic and endotoxic properties |
| Antigenic Nature used to produce antibodies | Heat killed cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab MASF(7,8)-l |
| Antibody type and class | IgG3 |
| Assay System | ELISA, agglutination tests |
| Cross-reactivity | This Mab showed excellent specificity for the 7,8 antigenic determinant [S. flexneri serotypes 2b, 3a, 5b, and X] |
| Proposed epitopes | This Mab apparently interact with the α-D-glucose p(1-->4)-α-L-rhamnosyl pIII epitope |
| IEDB Epitope | 76657 |
| Proposed Utility | This Mab can be used for detection and identification of shigella flexneri species |
| Curator ID | AA + AS |
| Date of Curation | 30-03-2011 |
| References | PMC272864 |
| PolysacDB ID | 2315 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Shigella flexneri serotype 2b (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Chemically, the O-antigen is a polysaccharide chain of variable length, built up by repetitive sequences of tetra- to hexasaccharides. It consists of a basic tetrasaccharide repeating unit consisting of three rhamnoses and one N-acetylglucosamine was common to all S. flexneri strains (except serotype 17): -2)-α-L-Rhap-[branched to α-D-Glcp(1-->4)](1-->2)-α-L-Rhap-(1-->3)-α-L-Rhap-[branched to α-D-Glcp(1-->3)](1-->3)-β-D-GlcpNAc-(1--> |
| BCSDB Structure | 108645 |
| Proposed functions | LPS plays an important virulence role based on its antiphagocytic and endotoxic properties |
| Antigenic Nature used to produce antibodies | Heat killed cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab MASF(HI)-1 |
| Antibody type and class | IgG3 |
| Assay System | ELISA, agglutination tests |
| Cross-reactivity | This Mab cross-reacted with 2a LPS |
| Proposed epitopes | This Mab apparently interact with the α-D-glucose p(1-->4)-α-L-rhamnosyl pIII epitope |
| IEDB Epitope | 76657 |
| Proposed Utility | This Mab can be used for detection and identification of shigella flexneri species |
| Curator ID | AA + AS |
| Date of Curation | 31-03-2011 |
| References | PMC272864 |
| PolysacDB ID | 2317 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Shigella flexneri serotype 2b (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Chemically, the O-antigen is a polysaccharide chain of variable length, built up by repetitive sequences of tetra- to hexasaccharides. It consists of a basic tetrasaccharide repeating unit consisting of three rhamnoses and one N-acetylglucosamine was common to all S. flexneri strains (except serotype 17): -2)-α-L-Rhap-[branched to α-D-Glcp(1-->4)](1-->2)-α-L-Rhap-(1-->3)-α-L-Rhap-[branched to α-D-Glcp(1-->3)](1-->3)-β-D-GlcpNAc-(1--> |
| BCSDB Structure | 108645 |
| Proposed functions | LPS plays an important virulence role based on its antiphagocytic and endotoxic properties |
| Antigenic Nature used to produce antibodies | Heat killed cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab MASF(7,8)-2 |
| Antibody type and class | IgG3 |
| Assay System | ELISA, agglutination tests |
| Cross-reactivity | This Mab showed excellent specificity for the 7,8 antigenic determinant [S. flexneri serotypes 2b, 3a, 5b, and X] |
| Proposed epitopes | This Mab reacts with α-D-glucose p(1-->3)-α-D-rhamnosyl pl epitope |
| IEDB Epitope | 76657 |
| Proposed Utility | This Mab can be used for detection and identification of shigella flexneri species |
| Curator ID | AA + AS |
| Date of Curation | 31-03-2011 |
| References | PMC272864 |
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Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020 |