PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID2293
Carbohydrate NameO-polysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeShigella dysenteriae   (NCBI Taxonomy)   (Drugpedia)
Basic StructureChemically, the O-antigen is a polysaccharide chain of variable length, built up by repetitive sequences of tetra- to hexasaccharides. It consists of a basic tetrasaccharide repeating unit consisting of three rhamnoses and one N-acetylglucosamine was common to all S. flexneri strains (except serotype 17): -2)-α-L-Rhap-(1-->2)-α-L-Rhap-(1-->3)-α-L-Rhap-(1-->3)-β-D-GlcpNAc-(1-->
BCSDB StructureN/A
Proposed functionsN/A
Antigenic Nature used to produce antibodiesHeat killed cells
Carrier NameNil
Conjugation MethodNil
AntibodiesMab 3707 E9
Antibody type and classIgM
Assay SystemELISA and immunoblotting
Cross-reactivityN/A
Proposed epitopesRhamnopyranosyl-α-( 1-->2)-galactopyranosyl disaccharide seemed to be the major antigenic determinanant
IEDB Epitope76808
Proposed UtilityThis Mab can help in the identification of immunodominant epitope in the O-antigen of Shigella dysenteriae LPS
Curator IDAA + AS
Date of Curation22-03-2011
References7503987


Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020