PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613

Total Entries - 15
Entry No. - 1 [TOP]

PolysacDB ID	1847
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis group C strain C11 (NCBI Taxonomy) (Drugpedia)
Basic Structure	It consists of a homopolymer of α(2-->9)-linked sialic acid residues
BCSDB Structure	3212
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 1702.10
Antibody type and class	IgM
Assay System	Fluorescence ELISA, Ouchterlony precipitation, Bacterial agglutination assay, Bactericidal assay
Cross-reactivity	This Mab reacted with natural O-acetyl-negative variant (OAc-, strain MC19) polysaccharide and did not react with K1 polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab had bactericidal activity
Curator ID	AA + AS
Date of Curation	14-11-2010
References	3143763

Entry No. - 2 [TOP]

PolysacDB ID	1848
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis group C strain C11 (NCBI Taxonomy) (Drugpedia)
Basic Structure	It consists of a homopolymer of α(2-->9)-linked sialic acid residues
BCSDB Structure	N/A
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 1863.5
Antibody type and class	IgM
Assay System	Fluorescence ELISA, Ouchterlony precipitation, Bacterial agglutination assay, Bactericidal assay
Cross-reactivity	This Mab was highly specific to group C polysaccharide and did not react with K1 polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab had bactericidal activity
Curator ID	AA + AS
Date of Curation	14-11-2010
References	3143763

Entry No. - 3 [TOP]

PolysacDB ID	1849
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis group C strain C11 (NCBI Taxonomy) (Drugpedia)
Basic Structure	It consists of a homopolymer of α(2-->9)-linked sialic acid residues
BCSDB Structure	N/A
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 1922.2
Antibody type and class	IgM
Assay System	Fluorescence ELISA, Ouchterlony precipitation, Bacterial agglutination assay, Bactericidal assay
Cross-reactivity	This Mab was highly specific to group C polysaccharide and did not react with K1 polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab had bactericidal activity
Curator ID	AA + AS
Date of Curation	14-11-2010
References	3143763

Entry No. - 4 [TOP]

PolysacDB ID	1850
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis group C strain C11 (NCBI Taxonomy) (Drugpedia)
Basic Structure	It consists of a homopolymer of α(2-->9)-linked sialic acid residues
BCSDB Structure	N/A
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 2010.10
Antibody type and class	IgM
Assay System	Fluorescence ELISA, Ouchterlony precipitation, Bacterial agglutination assay, Bactericidal assay
Cross-reactivity	This Mab reacted with natural O-acetyl-negative variant (OAc-, strain MC19) polysaccharide and did not react with K1 polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab had bactericidal activity
Curator ID	AA + AS
Date of Curation	15-11-2010
References	3143763

Entry No. - 5 [TOP]

PolysacDB ID	1851
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis group C strain C11 (NCBI Taxonomy) (Drugpedia)
Basic Structure	It consists of a homopolymer of α(2-->9)-linked sialic acid residues
BCSDB Structure	N/A
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 181.1
Antibody type and class	IgG3
Assay System	Fluorescence ELISA, Ouchterlony precipitation, Bacterial agglutination assay, Bactericidal assay
Cross-reactivity	This Mab reacted with natural O-acetyl-negative variant (OAc-, strain MC19) polysaccharide and did not react with K1 polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab had bactericidal activity
Curator ID	AA + AS
Date of Curation	15-11-2010
References	3143763

Entry No. - 6 [TOP]

PolysacDB ID	1852
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis group C strain C11 (NCBI Taxonomy) (Drugpedia)
Basic Structure	It consists of a homopolymer of α(2-->9)-linked sialic acid residues
BCSDB Structure	N/A
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 1705.18
Antibody type and class	IgG3
Assay System	Fluorescence ELISA, Ouchterlony precipitation, Bacterial agglutination assay, Bactericidal assay
Cross-reactivity	This Mab was highly specific to group C polysaccharide and did not react with K1 polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab had bactericidal activity
Curator ID	AA + AS
Date of Curation	15-11-2010
References	3143763

Entry No. - 7 [TOP]

PolysacDB ID	1853
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis group C strain C11 (NCBI Taxonomy) (Drugpedia)
Basic Structure	It consists of a homopolymer of α(2-->9)-linked sialic acid residues
BCSDB Structure	10814
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 1846.13
Antibody type and class	IgG3
Assay System	Fluorescence ELISA, Ouchterlony precipitation, Bacterial agglutination assay, Bactericidal assay
Cross-reactivity	This Mab was highly specific to group C polysaccharide and did not react with K1 polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab had bactericidal activity
Curator ID	AA + AS
Date of Curation	15-11-2010
References	3143763

Entry No. - 8 [TOP]

PolysacDB ID	1854
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis group C strain C11 (NCBI Taxonomy) (Drugpedia)
Basic Structure	It consists of a homopolymer of α(2-->9)-linked sialic acid residues
BCSDB Structure	N/A
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 2016.3
Antibody type and class	IgG3
Assay System	Fluorescence ELISA, Ouchterlony precipitation, Bacterial agglutination assay, Bactericidal assay
Cross-reactivity	This Mab reacted with natural O-acetyl-negative variant (OAc-, strain MC19) polysaccharide and did not react with K1 polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab had bactericidal activity
Curator ID	AA + AS
Date of Curation	16-11-2010
References	3143763

Entry No. - 9 [TOP]

PolysacDB ID	1855
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis group C strain C11 (NCBI Taxonomy) (Drugpedia)
Basic Structure	It consists of a homopolymer of α(2-->9)-linked sialic acid residues
BCSDB Structure	N/A
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 2055.5
Antibody type and class	IgG3
Assay System	Fluorescence ELISA, Ouchterlony precipitation, Bacterial agglutination assay, Bactericidal assay
Cross-reactivity	This Mab was highly specific to group C polysaccharide and did not react with K1 polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab had bactericidal activity
Curator ID	AA + AS
Date of Curation	16-11-2010
References	3143763

Entry No. - 10 [TOP]

PolysacDB ID	1856
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis group C strain C11 (NCBI Taxonomy) (Drugpedia)
Basic Structure	It consists of a homopolymer of α(2-->9)-linked sialic acid residues
BCSDB Structure	N/A
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 2750.27
Antibody type and class	IgG3
Assay System	Fluorescence ELISA, Ouchterlony precipitation, Bacterial agglutination assay, Bactericidal assay
Cross-reactivity	This Mab was highly specific to group C polysaccharide and did not react with K1 polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab had bactericidal activity
Curator ID	AA + AS
Date of Curation	16-11-2010
References	3143763

Entry No. - 11 [TOP]

PolysacDB ID	1857
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis group C strain C11 (NCBI Taxonomy) (Drugpedia)
Basic Structure	It consists of a homopolymer of α(2-->9)-linked sialic acid residues
BCSDB Structure	N/A
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 3006.18
Antibody type and class	IgG3
Assay System	Fluorescence ELISA, Ouchterlony precipitation, Bacterial agglutination assay, Bactericidal assay
Cross-reactivity	This Mab was highly specific to group C polysaccharide and did not react with K1 polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab had bactericidal activity
Curator ID	AA + AS
Date of Curation	16-11-2010
References	3143763

Entry No. - 12 [TOP]

PolysacDB ID	1858
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis group C strain C11 (NCBI Taxonomy) (Drugpedia)
Basic Structure	It consists of a homopolymer of α(2-->9)-linked sialic acid residues
BCSDB Structure	N/A
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 3079.6
Antibody type and class	IgG3
Assay System	Fluorescence ELISA, Ouchterlony precipitation, Bacterial agglutination assay, Bactericidal assay
Cross-reactivity	This Mab reacted with natural O-acetyl-negative variant (OAc-, strain MC19) polysaccharide and did not react with K1 polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab had bactericidal activity
Curator ID	AA + AS
Date of Curation	16-11-2010
References	3143763

Entry No. - 13 [TOP]

PolysacDB ID	1859
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis group C strain C11 (NCBI Taxonomy) (Drugpedia)
Basic Structure	It consists of a homopolymer of α(2-->9)-linked sialic acid residues
BCSDB Structure	N/A
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 177.16
Antibody type and class	IgG1
Assay System	Fluorescence ELISA, Ouchterlony precipitation, Bacterial agglutination assay, Bactericidal assay
Cross-reactivity	This Mab reacted with natural O-acetyl-negative variant (OAc-, strain MC19) polysaccharide and did not react with K1 polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab had bactericidal activity
Curator ID	AA + AS
Date of Curation	17-11-2010
References	3143763

Entry No. - 14 [TOP]

PolysacDB ID	1860
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis group C strain C11 (NCBI Taxonomy) (Drugpedia)
Basic Structure	It consists of a homopolymer of α(2-->9)-linked sialic acid residues
BCSDB Structure	N/A
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 1946.13
Antibody type and class	IgG1
Assay System	Fluorescence ELISA, Ouchterlony precipitation, Bacterial agglutination assay, Bactericidal assay
Cross-reactivity	This Mab was highly specific to group C polysaccharide and did not react with K1 polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab had bactericidal activity
Curator ID	AA + AS
Date of Curation	18-11-2010
References	3143763

Entry No. - 15 [TOP]

PolysacDB ID	1861
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis group C strain C11 (NCBI Taxonomy) (Drugpedia)
Basic Structure	It consists of a homopolymer of α(2-->9)-linked sialic acid residues
BCSDB Structure	N/A
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 78.2
Antibody type and class	IgG2b
Assay System	Fluorescence ELISA, Ouchterlony precipitation, Bacterial agglutination assay, Bactericidal assay
Cross-reactivity	This Mab was highly specific to group C polysaccharide and did not react with K1 polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab had bactericidal activity
Curator ID	AA + AS
Date of Curation	18-11-2010
References	3143763

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