PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613

Total Entries - 8
Entry No. - 1 [TOP]

PolysacDB ID	1881
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis group A strain A1 (NCBI Taxonomy) (Drugpedia)
Basic Structure	Neisseria meningitidis serogroup A capsular polysaccharide (CPS) is composed of a homopolymer of O-acetylated, α1-->6-linked ManNAc 1-phosphate
BCSDB Structure	3136
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 4385G7
Antibody type and class	IgG2b
Assay System	ELISA, immunodot assay, and ELISA inhibition assay
Cross-reactivity	This Mab was highly specific to A1 lipooligosaccharide but also cross-reacted with L8 lipooligosaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	N/A
Curator ID	AA + AS
Date of Curation	21-11-2010
References	PMC265440

Entry No. - 2 [TOP]

PolysacDB ID	1882
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis group A strain A1 (NCBI Taxonomy) (Drugpedia)
Basic Structure	Neisseria meningitidis serogroup A capsular polysaccharide (CPS) is composed of a homopolymer of O-acetylated, α1-->6-linked ManNAc 1-phosphate
BCSDB Structure	3136
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 4387A5
Antibody type and class	IgG2a
Assay System	ELISA, immunodot assay, and ELISA inhibition assay
Cross-reactivity	This Mab was highly specific to A1 lipooligosaccharide but also cross-reacted with L8 lipooligosaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	N/A
Curator ID	AA + AS
Date of Curation	21-11-2010
References	PMC265440

Entry No. - 3 [TOP]

PolysacDB ID	1883
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis group A strain A1 (NCBI Taxonomy) (Drugpedia)
Basic Structure	Neisseria meningitidis serogroup A capsular polysaccharide (CPS) is composed of a homopolymer of O-acetylated, α1-->6-linked ManNAc 1-phosphate
BCSDB Structure	3136
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 4361F3
Antibody type and class	IgM
Assay System	ELISA, immunodot assay, and ELISA inhibition assay
Cross-reactivity	This Mab was highly cross-reactive and reacted with all immunotypes except L6, L11 and L12
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	N/A
Curator ID	AA + AS
Date of Curation	22-11-2010
References	PMC265440

Entry No. - 4 [TOP]

PolysacDB ID	1884
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis group A strain A1 (NCBI Taxonomy) (Drugpedia)
Basic Structure	Neisseria meningitidis serogroup A capsular polysaccharide (CPS) is composed of a homopolymer of O-acetylated, α1-->6-linked ManNAc 1-phosphate
BCSDB Structure	3136
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 4362F4
Antibody type and class	IgM
Assay System	ELISA, immunodot assay, and ELISA inhibition assay
Cross-reactivity	This Mab was highly cross-reactive and reacted with all immunotypes except L5 and L6
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	N/A
Curator ID	AA + AS
Date of Curation	22-11-2010
References	PMC265440

Entry No. - 5 [TOP]

PolysacDB ID	1885
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis group A strain A1 (NCBI Taxonomy) (Drugpedia)
Basic Structure	Neisseria meningitidis serogroup A capsular polysaccharide (CPS) is composed of a homopolymer of O-acetylated, α1-->6-linked ManNAc 1-phosphate
BCSDB Structure	3136
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 4383D3
Antibody type and class	IgM
Assay System	ELISA, immunodot assay, and ELISA inhibition assay
Cross-reactivity	This Mab was highly cross-reactive and reacted with all immunotypes except L6, L11 and L14
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	N/A
Curator ID	AA + AS
Date of Curation	22-11-2010
References	PMC265440

Entry No. - 6 [TOP]

PolysacDB ID	1886
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis group A strain A1 (NCBI Taxonomy) (Drugpedia)
Basic Structure	Neisseria meningitidis serogroup A capsular polysaccharide (CPS) is composed of a homopolymer of O-acetylated, α1-->6-linked ManNAc 1-phosphate
BCSDB Structure	3136
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 4386B4
Antibody type and class	IgM
Assay System	ELISA, immunodot assay, and ELISA inhibition assay
Cross-reactivity	This Mab was highly cross-reactive and reacted with all immunotypes except L2, L4 and L6
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	N/A
Curator ID	AA + AS
Date of Curation	23-11-2010
References	PMC265440

Entry No. - 7 [TOP]

PolysacDB ID	1887
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis group A strain A1 (NCBI Taxonomy) (Drugpedia)
Basic Structure	Neisseria meningitidis serogroup A capsular polysaccharide (CPS) is composed of a homopolymer of O-acetylated, α1-->6-linked ManNAc 1-phosphate
BCSDB Structure	3136
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 4384H1
Antibody type and class	IgG3
Assay System	ELISA, immunodot assay, and ELISA inhibition assay
Cross-reactivity	This Mab was highly cross-reactive and reacted with all immunotypes except L2, L4, L5, L6, L7, L8
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	N/A
Curator ID	AA + AS
Date of Curation	23-11-2010
References	PMC265440

Entry No. - 8 [TOP]

PolysacDB ID	1888
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis group A strain A1 (NCBI Taxonomy) (Drugpedia)
Basic Structure	Neisseria meningitidis serogroup A capsular polysaccharide (CPS) is composed of a homopolymer of O-acetylated, α1-->6-linked ManNAc 1-phosphate
BCSDB Structure	3136
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	M7H4
Antibody type and class	IgG3
Assay System	ELISA, immunodot assay, and ELISA inhibition assay
Cross-reactivity	This Mab was highly cross-reactive and reacted with all immunotypes except L2, L4, L5, L6 and L9
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	N/A
Curator ID	AA + AS
Date of Curation	23-11-2010
References	PMC265440

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