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| PolysacDB ID | 1803 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Neisseria meningitidis Serogroup C (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->9)-linked sialic acid residues. |
| BCSDB Structure | 130704 |
| Proposed functions | It is an important virulence factor |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab 4-2-C |
| Antibody type and class | IgG3 |
| Assay System | ELISA |
| Cross-reactivity | This Mab was specific to Serogroup C and did not cross-react with other serogroups |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in serogrouping of Neisseria meningitidis strains |
| Curator ID | AA + AS |
| Date of Curation | 04-11-2010 |
| References | PMC540207 |
| PolysacDB ID | 1808 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Neisseria meningitidis Serogroup C (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->9)-linked sialic acid residues. |
| BCSDB Structure | 130704 |
| Proposed functions | It is an important virulence factor |
| Antigenic Nature used to produce antibodies | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugation Method | The oligosaccharide was activated using NaIO4 at 4°C for 60 min and combined with monomeric tetanus toxoid in sodium phosphate buffer containing NaBH3CN and heated at 37°C for 5 days |
| Antibodies | Mab C2/273.7 |
| Antibody type and class | IgA |
| Assay System | ELISA |
| Cross-reactivity | This Mab did not cross-react with the non-O-acetylated variant of capsular polysaccharide and also did not react with E. coli K92 capsular polysaccharide |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used for studying the capsular polysaccharide immunogenicity |
| Curator ID | AA + AS |
| Date of Curation | 05-11-2010 |
| References | PMC97127 |
| PolysacDB ID | 1809 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Neisseria meningitidis Serogroup C (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->9)-linked sialic acid residues. |
| BCSDB Structure | 130704 |
| Proposed functions | It is an important virulence factor |
| Antigenic Nature used to produce antibodies | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugation Method | The oligosaccharide was activated using NaIO4 at 4°C for 60 min and combined with monomeric tetanus toxoid in sodium phosphate buffer containing NaBH3CN and heated at 37°C for 5 days |
| Antibodies | Mab C2/969.3 |
| Antibody type and class | IgA |
| Assay System | ELISA |
| Cross-reactivity | This Mab cross-reacted with the non-O-acetylated variant of capsular polysaccharide but did not react with E. coli K92 capsular polysaccharide |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used for studying the capsular polysaccharide immunogenicity |
| Curator ID | AA + AS |
| Date of Curation | 05-11-2010 |
| References | PMC97127 |
| PolysacDB ID | 1810 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Neisseria meningitidis Serogroup C (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->9)-linked sialic acid residues. |
| BCSDB Structure | 130704 |
| Proposed functions | It is an important virulence factor |
| Antigenic Nature used to produce antibodies | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugation Method | The oligosaccharide was activated using NaIO4 at 4°C for 60 min and combined with monomeric tetanus toxoid in sodium phosphate buffer containing NaBH3CN and heated at 37°C for 5 days |
| Antibodies | Mab C2/205.10 |
| Antibody type and class | IgG1 |
| Assay System | ELISA |
| Cross-reactivity | This Mab did not cross-react with the non-O-acetylated variant of capsular polysaccharide and also did not react with E. coli K92 capsular polysaccharide |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used for studying the capsular polysaccharide immunogenicity |
| Curator ID | AA + AS |
| Date of Curation | 05-11-2010 |
| References | PMC97127 |
| PolysacDB ID | 1811 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Neisseria meningitidis Serogroup C (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->9)-linked sialic acid residues. |
| BCSDB Structure | 130704 |
| Proposed functions | It is an important virulence factor |
| Antigenic Nature used to produce antibodies | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugation Method | The oligosaccharide was activated using NaIO4 at 4°C for 60 min and combined with monomeric tetanus toxoid in sodium phosphate buffer containing NaBH3CN and heated at 37°C for 5 days |
| Antibodies | Mab C2/951.8 |
| Antibody type and class | IgG1 |
| Assay System | ELISA |
| Cross-reactivity | This Mab did not cross-react with the non-O-acetylated variant of capsular polysaccharide and also did not react with E. coli K92 capsular polysaccharide |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used for studying the capsular polysaccharide immunogenicity |
| Curator ID | AA + AS |
| Date of Curation | 05-11-2010 |
| References | PMC97127 |
| PolysacDB ID | 1812 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Neisseria meningitidis Serogroup C (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->9)-linked sialic acid residues. |
| BCSDB Structure | 130704 |
| Proposed functions | It is an important virulence factor |
| Antigenic Nature used to produce antibodies | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugation Method | The oligosaccharide was activated using NaIO4 at 4°C for 60 min and combined with monomeric tetanus toxoid in sodium phosphate buffer containing NaBH3CN and heated at 37°C for 5 days |
| Antibodies | Mab C2/630.10 |
| Antibody type and class | IgG1 |
| Assay System | ELISA |
| Cross-reactivity | This Mab cross-reacted with the non-O-acetylated variant of capsular polysaccharide but did not react with E. coli K92 capsular polysaccharide |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used for studying the capsular polysaccharide immunogenicity |
| Curator ID | AA + AS |
| Date of Curation | 06-11-2010 |
| References | PMC97127 |
| PolysacDB ID | 1813 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Neisseria meningitidis Serogroup C (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->9)-linked sialic acid residues. |
| BCSDB Structure | 130704 |
| Proposed functions | It is an important virulence factor |
| Antigenic Nature used to produce antibodies | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugation Method | The oligosaccharide was activated using NaIO4 at 4°C for 60 min and combined with monomeric tetanus toxoid in sodium phosphate buffer containing NaBH3CN and heated at 37°C for 5 days |
| Antibodies | Mab C2/735.4 |
| Antibody type and class | IgG1 |
| Assay System | ELISA |
| Cross-reactivity | This Mab did not cross-react with the non-O-acetylated variant of capsular polysaccharide and also did not react with E. coli K92 capsular polysaccharide |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used for studying the capsular polysaccharide immunogenicity |
| Curator ID | AA + AS |
| Date of Curation | 06-11-2010 |
| References | PMC97127 |
| PolysacDB ID | 1814 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Neisseria meningitidis Serogroup C (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->9)-linked sialic acid residues. |
| BCSDB Structure | 130704 |
| Proposed functions | It is an important virulence factor |
| Antigenic Nature used to produce antibodies | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugation Method | The oligosaccharide was activated using NaIO4 at 4°C for 60 min and combined with monomeric tetanus toxoid in sodium phosphate buffer containing NaBH3CN and heated at 37°C for 5 days |
| Antibodies | Mab C2/35.3 |
| Antibody type and class | IgG1 |
| Assay System | ELISA |
| Cross-reactivity | This Mab cross-reacted with the non-O-acetylated variant of capsular polysaccharide but did not react with E. coli K92 capsular polysaccharide |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used for studying the capsular polysaccharide immunogenicity |
| Curator ID | AA + AS |
| Date of Curation | 07-11-2010 |
| References | PMC97127 |
| PolysacDB ID | 1815 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Neisseria meningitidis Serogroup C (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->9)-linked sialic acid residues. |
| BCSDB Structure | 130704 |
| Proposed functions | It is an important virulence factor |
| Antigenic Nature used to produce antibodies | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugation Method | The oligosaccharide was activated using NaIO4 at 4°C for 60 min and combined with monomeric tetanus toxoid in sodium phosphate buffer containing NaBH3CN and heated at 37°C for 5 days |
| Antibodies | Mab C2/233.2 |
| Antibody type and class | IgG1 |
| Assay System | ELISA |
| Cross-reactivity | This Mab did not cross-react with the non-O-acetylated variant of capsular polysaccharide and also did not react with E. coli K92 capsular polysaccharide |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used for studying the capsular polysaccharide immunogenicity |
| Curator ID | AA + AS |
| Date of Curation | 07-11-2010 |
| References | PMC97127 |
| PolysacDB ID | 1816 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Neisseria meningitidis Serogroup C (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->9)-linked sialic acid residues. |
| BCSDB Structure | 130704 |
| Proposed functions | It is an important virulence factor |
| Antigenic Nature used to produce antibodies | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugation Method | The oligosaccharide was activated using NaIO4 at 4°C for 60 min and combined with monomeric tetanus toxoid in sodium phosphate buffer containing NaBH3CN and heated at 37°C for 5 days |
| Antibodies | Mab C2/256.8 |
| Antibody type and class | IgG1 |
| Assay System | ELISA |
| Cross-reactivity | This Mab cross-reacted with the non-O-acetylated variant of capsular polysaccharide but did not react with E. coli K92 capsular polysaccharide |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used for studying the capsular polysaccharide immunogenicity |
| Curator ID | AA + AS |
| Date of Curation | 07-11-2010 |
| References | PMC97127 |
| PolysacDB ID | 1817 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Neisseria meningitidis Serogroup C (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->9)-linked sialic acid residues. |
| BCSDB Structure | 130704 |
| Proposed functions | It is an important virulence factor |
| Antigenic Nature used to produce antibodies | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugation Method | The oligosaccharide was activated using NaIO4 at 4°C for 60 min and combined with monomeric tetanus toxoid in sodium phosphate buffer containing NaBH3CN and heated at 37°C for 5 days |
| Antibodies | Mab C2/998.3 |
| Antibody type and class | IgG1 |
| Assay System | ELISA |
| Cross-reactivity | This Mab cross-reacted with the non-O-acetylated variant of capsular polysaccharide but did not react with E. coli K92 capsular polysaccharide |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used for studying the capsular polysaccharide immunogenicity |
| Curator ID | AA + AS |
| Date of Curation | 07-11-2010 |
| References | PMC97127 |
| PolysacDB ID | 1818 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Neisseria meningitidis Serogroup C (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->9)-linked sialic acid residues. |
| BCSDB Structure | 130704 |
| Proposed functions | It is an important virulence factor |
| Antigenic Nature used to produce antibodies | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugation Method | The oligosaccharide was activated using NaIO4 at 4°C for 60 min and combined with monomeric tetanus toxoid in sodium phosphate buffer containing NaBH3CN and heated at 37°C for 5 days |
| Antibodies | Mab C2/974.1 |
| Antibody type and class | IgG1 |
| Assay System | ELISA |
| Cross-reactivity | This Mab cross-reacted with the non-O-acetylated variant of capsular polysaccharide and also cross-reacted with E. coli K92 capsular polysaccharide |
| Proposed epitopes | α(2-->9)-linked sialic acid backbone seemed to be the part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used for studying the capsular polysaccharide immunogenicity |
| Curator ID | AA + AS |
| Date of Curation | 08-11-2010 |
| References | PMC97127 |
| PolysacDB ID | 1819 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Neisseria meningitidis Serogroup C (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->9)-linked sialic acid residues. |
| BCSDB Structure | 130704 |
| Proposed functions | It is an important virulence factor |
| Antigenic Nature used to produce antibodies | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugation Method | The oligosaccharide was activated using NaIO4 at 4°C for 60 min and combined with monomeric tetanus toxoid in sodium phosphate buffer containing NaBH3CN and heated at 37°C for 5 days |
| Antibodies | Mab C2/1076.10 |
| Antibody type and class | IgG1 |
| Assay System | ELISA |
| Cross-reactivity | This Mab cross-reacted with the non-O-acetylated variant of capsular polysaccharide and also cross-reacted with E. coli K92 capsular polysaccharide |
| Proposed epitopes | α(2-->9)-linked sialic acid backbone seemed to be the part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used for studying the capsular polysaccharide immunogenicity |
| Curator ID | AA + AS |
| Date of Curation | 08-11-2010 |
| References | PMC97127 |
| PolysacDB ID | 1820 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Neisseria meningitidis Serogroup C (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->9)-linked sialic acid residues. |
| BCSDB Structure | 130704 |
| Proposed functions | It is an important virulence factor |
| Antigenic Nature used to produce antibodies | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugation Method | The oligosaccharide was activated using NaIO4 at 4°C for 60 min and combined with monomeric tetanus toxoid in sodium phosphate buffer containing NaBH3CN and heated at 37°C for 5 days |
| Antibodies | Mab C2/655.7 |
| Antibody type and class | IgG1 |
| Assay System | ELISA |
| Cross-reactivity | This Mab cross-reacted with the non-O-acetylated variant of capsular polysaccharide but did not react with E. coli K92 capsular polysaccharide |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used for studying the capsular polysaccharide immunogenicity |
| Curator ID | AA + AS |
| Date of Curation | 08-11-2010 |
| References | PMC97127 |
| PolysacDB ID | 1821 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Neisseria meningitidis Serogroup C (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->9)-linked sialic acid residues. |
| BCSDB Structure | 130704 |
| Proposed functions | It is an important virulence factor |
| Antigenic Nature used to produce antibodies | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugation Method | The oligosaccharide was activated using NaIO4 at 4°C for 60 min and combined with monomeric tetanus toxoid in sodium phosphate buffer containing NaBH3CN and heated at 37°C for 5 days |
| Antibodies | Mab C2/181.7 |
| Antibody type and class | IgG1 |
| Assay System | ELISA |
| Cross-reactivity | This Mab cross-reacted with the non-O-acetylated variant of capsular polysaccharide but did not react with E. coli K92 capsular polysaccharide |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used for studying the capsular polysaccharide immunogenicity |
| Curator ID | AA + AS |
| Date of Curation | 08-11-2010 |
| References | PMC97127 |
| PolysacDB ID | 1822 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Neisseria meningitidis Serogroup C (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->9)-linked sialic acid residues. |
| BCSDB Structure | 130704 |
| Proposed functions | It is an important virulence factor |
| Antigenic Nature used to produce antibodies | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugation Method | The oligosaccharide was activated using NaIO4 at 4°C for 60 min and combined with monomeric tetanus toxoid in sodium phosphate buffer containing NaBH3CN and heated at 37°C for 5 days |
| Antibodies | Mab C2/706.12 |
| Antibody type and class | IgG1 |
| Assay System | ELISA |
| Cross-reactivity | This Mab cross-reacted with the non-O-acetylated variant of capsular polysaccharide and also cross-reacted with E. coli K92 capsular polysaccharide |
| Proposed epitopes | α(2-->9)-linked sialic acid backbone seemed to be the part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used for studying the capsular polysaccharide immunogenicity |
| Curator ID | AA + AS |
| Date of Curation | 09-11-2010 |
| References | PMC97127 |
| PolysacDB ID | 1823 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Neisseria meningitidis Serogroup C (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->9)-linked sialic acid residues. |
| BCSDB Structure | 130704 |
| Proposed functions | It is an important virulence factor |
| Antigenic Nature used to produce antibodies | Glycoconjugates as well as purified capsular polysaccharide |
| Carrier Name | Tetanus toxoid |
| Conjugation Method | The oligosaccharide was activated using NaIO4 at 4°C for 60 min and combined with monomeric tetanus toxoid in sodium phosphate buffer containing NaBH3CN and heated at 37°C for 5 days |
| Antibodies | Mab CP1049.19 |
| Antibody type and class | IgG1 |
| Assay System | ELISA |
| Cross-reactivity | This Mab did not cross-react with the non-O-acetylated variant of capsular polysaccharide and also did not react with E. coli K92 capsular polysaccharide |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used for studying the capsular polysaccharide immunogenicity |
| Curator ID | AA + AS |
| Date of Curation | 09-11-2010 |
| References | PMC97127 |
| PolysacDB ID | 1824 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Neisseria meningitidis Serogroup C (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->9)-linked sialic acid residues. |
| BCSDB Structure | 130704 |
| Proposed functions | It is an important virulence factor |
| Antigenic Nature used to produce antibodies | Glycoconjugates as well as purified capsular polysaccharide |
| Carrier Name | Tetanus toxoid |
| Conjugation Method | The oligosaccharide was activated using NaIO4 at 4°C for 60 min and combined with monomeric tetanus toxoid in sodium phosphate buffer containing NaBH3CN and heated at 37°C for 5 days |
| Antibodies | Mab CP875.2 |
| Antibody type and class | IgG1 |
| Assay System | ELISA |
| Cross-reactivity | This Mab cross-reacted with the non-O-acetylated variant of capsular polysaccharide but did not react with E. coli K92 capsular polysaccharide |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used for studying the capsular polysaccharide immunogenicity |
| Curator ID | AA + AS |
| Date of Curation | 09-11-2010 |
| References | PMC97127 |
| PolysacDB ID | 1825 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Neisseria meningitidis Serogroup C (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->9)-linked sialic acid residues. |
| BCSDB Structure | 130704 |
| Proposed functions | It is an important virulence factor |
| Antigenic Nature used to produce antibodies | Glycoconjugates as well as purified capsular polysaccharide |
| Carrier Name | Tetanus toxoid |
| Conjugation Method | The oligosaccharide was activated using NaIO4 at 4°C for 60 min and combined with monomeric tetanus toxoid in sodium phosphate buffer containing NaBH3CN and heated at 37°C for 5 days |
| Antibodies | Mab CP882.2 |
| Antibody type and class | IgG1 |
| Assay System | ELISA |
| Cross-reactivity | This Mab did not cross-react with the non-O-acetylated variant of capsular polysaccharide and also did not react with E. coli K92 capsular polysaccharide |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used for studying the capsular polysaccharide immunogenicity |
| Curator ID | AA + AS |
| Date of Curation | 09-11-2010 |
| References | PMC97127 |
| PolysacDB ID | 1826 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Neisseria meningitidis Serogroup C (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->9)-linked sialic acid residues. |
| BCSDB Structure | 130704 |
| Proposed functions | It is an important virulence factor |
| Antigenic Nature used to produce antibodies | Glycoconjugates as well as purified capsular polysaccharide |
| Carrier Name | Tetanus toxoid |
| Conjugation Method | The oligosaccharide was activated using NaIO4 at 4°C for 60 min and combined with monomeric tetanus toxoid in sodium phosphate buffer containing NaBH3CN and heated at 37°C for 5 days |
| Antibodies | Mab CP947.6 |
| Antibody type and class | IgG1 |
| Assay System | ELISA |
| Cross-reactivity | This Mab cross-reacted with the non-O-acetylated variant of capsular polysaccharide but did not react with E. coli K92 capsular polysaccharide |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used for studying the capsular polysaccharide immunogenicity |
| Curator ID | AA + AS |
| Date of Curation | 09-11-2010 |
| References | PMC97127 |
| PolysacDB ID | 1827 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Neisseria meningitidis Serogroup C (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->9)-linked sialic acid residues. |
| BCSDB Structure | 130704 |
| Proposed functions | It is an important virulence factor |
| Antigenic Nature used to produce antibodies | Glycoconjugates as well as purified capsular polysaccharide |
| Carrier Name | Tetanus toxoid |
| Conjugation Method | The oligosaccharide was activated using NaIO4 at 4°C for 60 min and combined with monomeric tetanus toxoid in sodium phosphate buffer containing NaBH3CN and heated at 37°C for 5 days |
| Antibodies | Mab CP1092.23 |
| Antibody type and class | IgG1 |
| Assay System | ELISA |
| Cross-reactivity | This Mab cross-reacted with the non-O-acetylated variant of capsular polysaccharide but did not react with E. coli K92 capsular polysaccharide |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used for studying the capsular polysaccharide immunogenicity |
| Curator ID | AA + AS |
| Date of Curation | 10-11-2010 |
| References | PMC97127 |
| PolysacDB ID | 1828 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Neisseria meningitidis Serogroup C (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->9)-linked sialic acid residues. |
| BCSDB Structure | 130704 |
| Proposed functions | It is an important virulence factor |
| Antigenic Nature used to produce antibodies | Glycoconjugates as well as purified capsular polysaccharide |
| Carrier Name | Tetanus toxoid |
| Conjugation Method | The oligosaccharide was activated using NaIO4 at 4°C for 60 min and combined with monomeric tetanus toxoid in sodium phosphate buffer containing NaBH3CN and heated at 37°C for 5 days |
| Antibodies | Mab CP1160.12 |
| Antibody type and class | IgG1 |
| Assay System | ELISA |
| Cross-reactivity | This Mab cross-reacted with the non-O-acetylated variant of capsular polysaccharide but did not react with E. coli K92 capsular polysaccharide |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used for studying the capsular polysaccharide immunogenicity |
| Curator ID | AA + AS |
| Date of Curation | 10-11-2010 |
| References | PMC97127 |
| PolysacDB ID | 1829 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Neisseria meningitidis Serogroup C (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->9)-linked sialic acid residues. |
| BCSDB Structure | 130704 |
| Proposed functions | It is an important virulence factor |
| Antigenic Nature used to produce antibodies | Glycoconjugates as well as purified capsular polysaccharide |
| Carrier Name | Tetanus toxoid |
| Conjugation Method | The oligosaccharide was activated using NaIO4 at 4°C for 60 min and combined with monomeric tetanus toxoid in sodium phosphate buffer containing NaBH3CN and heated at 37°C for 5 days |
| Antibodies | Mab CP163.6 |
| Antibody type and class | IgG1 |
| Assay System | ELISA |
| Cross-reactivity | This Mab cross-reacted with the non-O-acetylated variant of capsular polysaccharide but did not react with E. coli K92 capsular polysaccharide |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used for studying the capsular polysaccharide immunogenicity |
| Curator ID | AA + AS |
| Date of Curation | 10-11-2010 |
| References | PMC97127 |
| PolysacDB ID | 1830 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Neisseria meningitidis Serogroup C (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consists of a homopolymer of α(2-->9)-linked sialic acid residues. |
| BCSDB Structure | 130704 |
| Proposed functions | It is an important virulence factor |
| Antigenic Nature used to produce antibodies | Glycoconjugates as well as purified capsular polysaccharide |
| Carrier Name | Tetanus toxoid |
| Conjugation Method | The oligosaccharide was activated using NaIO4 at 4°C for 60 min and combined with monomeric tetanus toxoid in sodium phosphate buffer containing NaBH3CN and heated at 37°C for 5 days |
| Antibodies | Mab CP1050.20 |
| Antibody type and class | IgG2b |
| Assay System | ELISA |
| Cross-reactivity | This Mab did not cross-react with the non-O-acetylated variant of capsular polysaccharide and also did not react with E. coli K92 capsular polysaccharide |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used for studying the capsular polysaccharide immunogenicity |
| Curator ID | AA + AS |
| Date of Curation | 10-11-2010 |
| References | PMC97127 |
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Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020 |