PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613

Total Entries - 51
Entry No. - 1 [TOP]

PolysacDB ID	1070
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	The capsular polysaccharide, also known as K-antigen consists of repeating units of following residues : -8)α-Neup5Ac(2- [a homopolymer of α(2-->8) sialic acid residues]
BCSDB Structure	139710
Proposed functions	N/A
Antigenic Nature used to produce antibodies	Live group B type 15 meningococci cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 2-2-B
Antibody type and class	IgM
Assay System	ELISA and Radioimmunoassay
Cross-reactivity	This antibody cross-reacted with E. coli strain K1 Capsular polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab provided protection against the E. coli K-1 strain
Curator ID	AA + AS
Date of Curation	21-01-2010
References	PMC261141

Entry No. - 2 [TOP]

PolysacDB ID	1578
Carbohydrate Name	N-propionylated group B meningococcal polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	Nil
Antibodies	Polysera
Antibody type and class	N/A
Assay System	Radioactive binding inhibition assay, ELISA, Bactericidal assay
Cross-reactivity	This antisera cross-reacted with capsular polysaccharide of E. coli K1
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This antisera was bactericidal for Group B meningococci
Curator ID	AA + AS
Date of Curation	12-09-2010
References	2469720

Entry No. - 3 [TOP]

PolysacDB ID	1579
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature
Antibodies	Mab Seam 10
Antibody type and class	IgG1
Assay System	ELISA, flow cytometry and indirect immunofluorescence
Cross-reactivity	This Mab cross-reacted with non-modified acetylaed group B capsular polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease
Curator ID	AA + AS
Date of Curation	13-09-2010
References	9590252

Entry No. - 4 [TOP]

PolysacDB ID	1580
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature
Antibodies	Mab Seam 11
Antibody type and class	IgG2b
Assay System	ELISA, flow cytometry and indirect immunofluorescence
Cross-reactivity	This Mab cross-reacted with non-modified acetylaed group B capsular polysaccharide. This Mab also cross-reacted with polysialic acid on CHP-134 neuroblastoma cells
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease. This Mab induced bactericidal activity with rabbit complement
Curator ID	AA + AS
Date of Curation	13-09-2010
References	9590252

Entry No. - 5 [TOP]

PolysacDB ID	1581
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature
Antibodies	Mab Seam 12
Antibody type and class	IgG2a
Assay System	ELISA, flow cytometry and indirect immunofluorescence
Cross-reactivity	This Mab cross-reacted with non-modified acetylaed group B capsular polysaccharide. This Mab also cross-reacted with polysialic acid on CHP-134 neuroblastoma cells
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease. This Mab induced bactericidal activity with rabbit and human complement
Curator ID	AA + AS
Date of Curation	13-09-2010
References	9590252

Entry No. - 6 [TOP]

PolysacDB ID	1582
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature
Antibodies	Mab Seam 13
Antibody type and class	IgG3
Assay System	ELISA, flow cytometry and indirect immunofluorescence
Cross-reactivity	This Mab cross-reacted with non-modified acetylaed group B capsular polysaccharide. This Mab also cross-reacted with polysialic acid on CHP-134 neuroblastoma cells
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease. This Mab induced bactericidal activity with rabbit and human complement
Curator ID	AA + AS
Date of Curation	14-09-2010
References	9590252

Entry No. - 7 [TOP]

PolysacDB ID	1583
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature
Antibodies	Mab Seam 14
Antibody type and class	IgG2b
Assay System	ELISA, flow cytometry and indirect immunofluorescence
Cross-reactivity	This Mab cross-reacted with non-modified acetylaed group B capsular polysaccharide. This Mab also cross-reacted with polysialic acid on CHP-134 neuroblastoma cells
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease. This Mab induced bactericidal activity with rabbit complement
Curator ID	AA + AS
Date of Curation	14-09-2010
References	9590252

Entry No. - 8 [TOP]

PolysacDB ID	1584
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature
Antibodies	Mab Seam 15
Antibody type and class	IgG2b
Assay System	ELISA, flow cytometry and indirect immunofluorescence
Cross-reactivity	This Mab cross-reacted with non-modified acetylaed group B capsular polysaccharide. This Mab also cross-reacted with polysialic acid on CHP-134 neuroblastoma cells
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease. This Mab induced bactericidal activity with rabbit complement
Curator ID	AA + AS
Date of Curation	14-09-2010
References	9590252

Entry No. - 9 [TOP]

PolysacDB ID	1585
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature
Antibodies	Mab Seam 16
Antibody type and class	IgG2b
Assay System	ELISA, flow cytometry and indirect immunofluorescence
Cross-reactivity	This Mab cross-reacted with non-modified acetylaed group B capsular polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease. This Mab induced bactericidal activity with rabbit complement
Curator ID	AA + AS
Date of Curation	15-09-2010
References	9590252

Entry No. - 10 [TOP]

PolysacDB ID	1586
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature
Antibodies	Mab Seam 17
Antibody type and class	IgM
Assay System	ELISA, flow cytometry and indirect immunofluorescence
Cross-reactivity	This Mab did not cross-react with non-modified acetylaed group B capsular polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease
Curator ID	AA + AS
Date of Curation	16-09-2010
References	9590252

Entry No. - 11 [TOP]

PolysacDB ID	1587
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature
Antibodies	Mab Seam 18
Antibody type and class	IgG2b
Assay System	ELISA, flow cytometry and indirect immunofluorescence
Cross-reactivity	This Mab cross-reacted with non-modified acetylaed group B capsular polysaccharide. This Mab also cross-reacted with polysialic acid on CHP-134 neuroblastoma cells
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease. This Mab induced bactericidal activity with rabbit and human complement
Curator ID	AA + AS
Date of Curation	16-09-2010
References	9590252

Entry No. - 12 [TOP]

PolysacDB ID	1588
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature
Antibodies	Mab Seam 19
Antibody type and class	IgG2a
Assay System	ELISA, flow cytometry and indirect immunofluorescence
Cross-reactivity	This Mab did not cross-react with non-modified acetylaed group B capsular polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease
Curator ID	AA + AS
Date of Curation	16-09-2010
References	9590252

Entry No. - 13 [TOP]

PolysacDB ID	1589
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature
Antibodies	Mab Seam 20
Antibody type and class	IgG2b
Assay System	ELISA, flow cytometry and indirect immunofluorescence
Cross-reactivity	This Mab cross-reacted with non-modified acetylaed group B capsular polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease
Curator ID	AA + AS
Date of Curation	16-09-2010
References	9590252

Entry No. - 14 [TOP]

PolysacDB ID	1590
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature
Antibodies	Mab Seam 21
Antibody type and class	IgG2b
Assay System	ELISA, flow cytometry and indirect immunofluorescence
Cross-reactivity	This Mab cross-reacted with non-modified acetylaed group B capsular polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease
Curator ID	AA + AS
Date of Curation	16-09-2010
References	9590252

Entry No. - 15 [TOP]

PolysacDB ID	1591
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature
Antibodies	Mab Seam 22
Antibody type and class	IgG2b
Assay System	ELISA, flow cytometry and indirect immunofluorescence
Cross-reactivity	This Mab did not cross-react with non-modified acetylaed group B capsular polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease
Curator ID	AA + AS
Date of Curation	17-09-2010
References	9590252

Entry No. - 16 [TOP]

PolysacDB ID	1592
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature
Antibodies	Mab Seam 23
Antibody type and class	IgG2b
Assay System	ELISA, flow cytometry and indirect immunofluorescence
Cross-reactivity	This Mab did not cross-react with non-modified acetylaed group B capsular polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease
Curator ID	AA + AS
Date of Curation	17-09-2010
References	9590252

Entry No. - 17 [TOP]

PolysacDB ID	1593
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature
Antibodies	Mab Seam 24
Antibody type and class	IgG2b
Assay System	ELISA, flow cytometry and indirect immunofluorescence
Cross-reactivity	This Mab did not cross-react with non-modified acetylaed group B capsular polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease
Curator ID	AA + AS
Date of Curation	17-09-2010
References	9590252

Entry No. - 18 [TOP]

PolysacDB ID	1594
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature
Antibodies	Mab Seam 25
Antibody type and class	IgG2b
Assay System	ELISA, flow cytometry and indirect immunofluorescence
Cross-reactivity	This Mab cross-reacted with non-modified acetylaed group B capsular polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease
Curator ID	AA + AS
Date of Curation	17-09-2010
References	9590252

Entry No. - 19 [TOP]

PolysacDB ID	1595
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature
Antibodies	Mab Seam 26
Antibody type and class	IgG2b
Assay System	ELISA, flow cytometry and indirect immunofluorescence
Cross-reactivity	This Mab cross-reacted with non-modified acetylaed group B capsular polysaccharide. This Mab also cross-reacted with polysialic acid on CHP-134 neuroblastoma cells
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease. This Mab induced bactericidal activity with rabbit complement
Curator ID	AA + AS
Date of Curation	18-09-2010
References	9590252

Entry No. - 20 [TOP]

PolysacDB ID	1596
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature
Antibodies	Mab Seam 28
Antibody type and class	IgG2b
Assay System	ELISA, flow cytometry and indirect immunofluorescence
Cross-reactivity	This Mab cross-reacted with non-modified acetylaed group B capsular polysaccharide. This Mab also cross-reacted with polysialic acid on CHP-134 neuroblastoma cells
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease. This Mab induced bactericidal activity with rabbit complement
Curator ID	AA + AS
Date of Curation	18-09-2010
References	9590252

Entry No. - 21 [TOP]

PolysacDB ID	1597
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature
Antibodies	Mab Seam 29
Antibody type and class	IgG2a
Assay System	ELISA, flow cytometry and indirect immunofluorescence
Cross-reactivity	This Mab cross-reacted with non-modified acetylaed group B capsular polysaccharide. This Mab also cross-reacted with polysialic acid on CHP-134 neuroblastoma cells
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease
Curator ID	AA + AS
Date of Curation	18-09-2010
References	9590252

Entry No. - 22 [TOP]

PolysacDB ID	1598
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature
Antibodies	Mab Seam 30
Antibody type and class	IgG3
Assay System	ELISA, flow cytometry and indirect immunofluorescence
Cross-reactivity	This Mab cross-reacted with non-modified acetylaed group B capsular polysaccharide. This Mab also cross-reacted with polysialic acid on CHP-134 neuroblastoma cells
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease. This Mab induced bactericidal activity with rabbit and human complement
Curator ID	AA + AS
Date of Curation	19-09-2010
References	9590252

Entry No. - 23 [TOP]

PolysacDB ID	1599
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature
Antibodies	Mab Seam 48
Antibody type and class	IgG2b
Assay System	ELISA, flow cytometry and indirect immunofluorescence
Cross-reactivity	This Mab did not cross-react with non-modified acetylaed group B capsular polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease. This Mab induced bactericidal activity with rabbit complement
Curator ID	AA + AS
Date of Curation	19-09-2010
References	9590252

Entry No. - 24 [TOP]

PolysacDB ID	1600
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature
Antibodies	Mab Seam 2
Antibody type and class	IgG3
Assay System	ELISA, flow cytometry and indirect immunofluorescence
Cross-reactivity	This Mab did not cross-react with non-modified acetylaed group B capsular polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease. This Mab induced bactericidal activity with rabbit and human complement
Curator ID	AA + AS
Date of Curation	20-09-2010
References	9590252

Entry No. - 25 [TOP]

PolysacDB ID	1601
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature
Antibodies	Mab Seam 6
Antibody type and class	IgG3
Assay System	ELISA, flow cytometry and indirect immunofluorescence
Cross-reactivity	This Mab did not cross-react with non-modified acetylaed group B capsular polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease
Curator ID	AA + AS
Date of Curation	20-09-2010
References	9590252

Entry No. - 26 [TOP]

PolysacDB ID	1602
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature
Antibodies	Mab Seam 9
Antibody type and class	IgG1
Assay System	ELISA, flow cytometry and indirect immunofluorescence
Cross-reactivity	This Mab did not cross-react with non-modified acetylaed group B capsular polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease
Curator ID	AA + AS
Date of Curation	20-09-2010
References	9590252

Entry No. - 27 [TOP]

PolysacDB ID	1603
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature
Antibodies	Mab Seam 1
Antibody type and class	IgG3
Assay System	ELISA, flow cytometry and indirect immunofluorescence
Cross-reactivity	This Mab did not cross-react with non-modified acetylaed group B capsular polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease. This Mab induced bactericidal activity with rabbit complement
Curator ID	AA + AS
Date of Curation	20-09-2010
References	9590252

Entry No. - 28 [TOP]

PolysacDB ID	1604
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature
Antibodies	Mab Seam 35
Antibody type and class	IgG2b
Assay System	ELISA, flow cytometry and indirect immunofluorescence
Cross-reactivity	This Mab cross-reacted with non-modified acetylaed group B capsular polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease
Curator ID	AA + AS
Date of Curation	21-09-2010
References	9590252

Entry No. - 29 [TOP]

PolysacDB ID	1605
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature
Antibodies	Mab Seam 3
Antibody type and class	IgG2b
Assay System	ELISA, flow cytometry and indirect immunofluorescence
Cross-reactivity	This Mab did not cross-react with non-modified acetylaed group B capsular polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease. This Mab induced bactericidal activity with rabbit complement
Curator ID	AA + AS
Date of Curation	21-09-2010
References	9590252

Entry No. - 30 [TOP]

PolysacDB ID	1606
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature
Antibodies	Mab Seam 4
Antibody type and class	IgG1
Assay System	ELISA, flow cytometry and indirect immunofluorescence
Cross-reactivity	This Mab did not cross-react with non-modified acetylaed group B capsular polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease
Curator ID	AA + AS
Date of Curation	22-09-2010
References	9590252

Entry No. - 31 [TOP]

PolysacDB ID	1607
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature
Antibodies	Mab Seam 5
Antibody type and class	IgG3
Assay System	ELISA, flow cytometry and indirect immunofluorescence
Cross-reactivity	This Mab did not cross-react with non-modified acetylaed group B capsular polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease. This Mab induced bactericidal activity with rabbit and human complement
Curator ID	AA + AS
Date of Curation	22-09-2010
References	9590252

Entry No. - 32 [TOP]

PolysacDB ID	1608
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature
Antibodies	Mab Seam 7
Antibody type and class	IgG3
Assay System	ELISA, flow cytometry and indirect immunofluorescence
Cross-reactivity	This Mab did not cross-react with non-modified acetylaed group B capsular polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease. This Mab induced bactericidal activity with rabbit and human complement
Curator ID	AA + AS
Date of Curation	22-09-2010
References	9590252

Entry No. - 33 [TOP]

PolysacDB ID	1609
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Glycoconjugates
Carrier Name	Tetanus toxoid
Conjugation Method	The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature
Antibodies	Mab Seam 8
Antibody type and class	IgG3
Assay System	ELISA, flow cytometry and indirect immunofluorescence
Cross-reactivity	This Mab did not cross-react with non-modified acetylaed group B capsular polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease. This Mab induced bactericidal activity with rabbit and human complement
Curator ID	AA + AS
Date of Curation	22-09-2010
References	9590252

Entry No. - 34 [TOP]

PolysacDB ID	1610
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	A patient suffering from IgM lambda monoclonal gammopathy
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab NOV
Antibody type and class	IgM
Assay System	Ouchterlony Gel Diffusion, ELISA, invivo protection assays
Cross-reactivity	This Mab reacted with group B meningococcal and E. coli K1 capsular polysaccharides and did not react with a(2 --> 9)-linked poly-N-acetylneuraminic acid, the capsular polysaccharide of the group C meningococcus, nor with the capsular polysaccharide of E. coli K92 or K100. It also crossreacts with polynucleotides and denatured DNA
Proposed epitopes	The epitope was proposed to consist of α(2-->8)-linked poly-N-acetylneuraminic acid
IEDB Epitope	N/A
Proposed Utility	This Mab is protective against E. coli in newborn rats
Curator ID	AA + AS
Date of Curation	22-09-2010
References	PMC2188242

Entry No. - 35 [TOP]

PolysacDB ID	1611
Carbohydrate Name	N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It is a homopolymer of α(2-->8) sialic acid
BCSDB Structure	N/A
Proposed functions	This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 735D4
Antibody type and class	IgG2a
Assay System	ELISA, Immunoelectrophoresis and immunodiffusion
Cross-reactivity	This Mab reacted with with all E. coli K1 and group B meningococcal strains tested but did not react with E. coli strains having capsular types K12, K13, K14, and K92; and group A and C meningococci
Proposed epitopes	The epitope was proposed to consist of repeating α(2-->8)-linked Neu5Ac units
IEDB Epitope	N/A
Proposed Utility	This antibody is an important addition to the analyticaln tools available for the study of the structure and function of the E. coli K1 and meningococcal B capsules
Curator ID	AA + AS
Date of Curation	22-09-2010
References	397221

Entry No. - 36 [TOP]

PolysacDB ID	1802
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It consists of a homopolymer of α(2-->8)-linked sialic acid residues
BCSDB Structure	7487
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 2-2-B
Antibody type and class	IgM
Assay System	ELISA
Cross-reactivity	This Mab was specific to Serogroup B and did not cross-react with other serogroups
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab would help in serogrouping of Neisseria meningitidis strains
Curator ID	AA + AS
Date of Curation	04-11-2010
References	PMC540207

Entry No. - 37 [TOP]

PolysacDB ID	1806
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It consists of a homopolymer of α(2-->8)-linked sialic acid residues
BCSDB Structure	7487
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 101C11
Antibody type and class	IgG2a
Assay System	ELISA and bactericidal assays
Cross-reactivity	This Mab was specifc to Neisseria meningitidis group B and did not cross-react with group A and group C N. meningitidis capsular polysaccharides. This Mab also recognized N-propionylated capsular polysaccharide of group B meningitidis
Proposed epitopes	α[2-->8] linked N-acetyl neuraminic acid residues seemed to be the part of the epitope
IEDB Epitope	N/A
Proposed Utility	This Mab had potent bactericidal activity
Curator ID	AA + AS
Date of Curation	05-11-2010
References	1284118

Entry No. - 38 [TOP]

PolysacDB ID	1807
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It consists of a homopolymer of α(2-->8)-linked sialic acid residues
BCSDB Structure	7487
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 30H12
Antibody type and class	IgG2a
Assay System	ELISA and bactericidal assays
Cross-reactivity	This Mab was specifc to Neisseria meningitidis group B and did not cross-react with group A and group C N. meningitidis capsular polysaccharides. This Mab did not recognized N-propionylated capsular polysaccharide of group B meningitidis
Proposed epitopes	α[2-->8] linked N-acetyl neuraminic acid residues seemed to be the part of the epitope
IEDB Epitope	N/A
Proposed Utility	This Mab had potent bactericidal activity
Curator ID	AA + AS
Date of Curation	05-11-2010
References	1284118

Entry No. - 39 [TOP]

PolysacDB ID	1862
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It consists of a homopolymer of α(2-->8)-linked sialic acid residues
BCSDB Structure	7487
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 10C11
Antibody type and class	IgG2a
Assay System	ELISA and bactericidal assays
Cross-reactivity	This Mab cross-reacts with E. coli K1 polysaccharide but does not react with E. coli K92, group A and group C polysaccharides of Neisseria meningitidis. This Mab also reacts with N-propionylated group B polysaccharide
Proposed epitopes	The epitope consisted of α2-8 linked sialic acid residues
IEDB Epitope	N/A
Proposed Utility	This Mab had bactericidal activity
Curator ID	AA + AS
Date of Curation	18-11-2010
References	1284118

Entry No. - 40 [TOP]

PolysacDB ID	1864
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It consists of a homopolymer of α(2-->8)-linked sialic acid residues
BCSDB Structure	7487
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Infected patient
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab BES
Antibody type and class	IgM
Assay System	ELISA, Rat protection assay
Cross-reactivity	This Mab cross-reacts with E. coli K1 polysaccharide but does not react with E. coli K92, group A and group C polysaccharides of Neisseria meningitidis. This Mab also reacts with N-propionylated group B polysaccharide
Proposed epitopes	The epitope consisted of α2-8 linked N-acetylneuraminic acid acid residues
IEDB Epitope	N/A
Proposed Utility	This antibody protected infant rats from bacteremia caused by Escherichia coli K1
Curator ID	AA + AS
Date of Curation	18-11-2010
References	PMC173242

Entry No. - 41 [TOP]

PolysacDB ID	1865
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It consists of a homopolymer of α(2-->8)-linked sialic acid residues
BCSDB Structure	7487
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Infected patient
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab KLOT
Antibody type and class	IgM
Assay System	ELISA, Rat protection assay
Cross-reactivity	This Mab cross-reacts with E. coli K1 polysaccharide but does not react with E. coli K92, group A and group C polysaccharides of Neisseria meningitidis. This Mab also reacts with N-propionylated group B polysaccharide
Proposed epitopes	The epitope consisted of α2-8 linked N-acetylneuraminic acid acid residues
IEDB Epitope	N/A
Proposed Utility	This antibody protected infant rats from bacteremia caused by Escherichia coli K1
Curator ID	AA + AS
Date of Curation	18-11-2010
References	PMC173242

Entry No. - 42 [TOP]

PolysacDB ID	1866
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It consists of a homopolymer of α(2-->8)-linked sialic acid residues
BCSDB Structure	7487
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Infected patient
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab LOG
Antibody type and class	IgM
Assay System	ELISA, Rat protection assay
Cross-reactivity	This Mab cross-reacts with E. coli K1 polysaccharide but does not react with E. coli K92, group A and group C polysaccharides of Neisseria meningitidis. This Mab also reacts with N-propionylated group B polysaccharide
Proposed epitopes	The epitope consisted of α2-8 linked N-acetylneuraminic acid acid residues
IEDB Epitope	N/A
Proposed Utility	This antibody protected infant rats from bacteremia caused by Escherichia coli K1
Curator ID	AA + AS
Date of Curation	18-11-2010
References	PMC173242

Entry No. - 43 [TOP]

PolysacDB ID	1867
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It consists of a homopolymer of α(2-->8)-linked sialic acid residues
BCSDB Structure	7487
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Infected patient
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab VAN
Antibody type and class	IgM
Assay System	ELISA, Rat protection assay
Cross-reactivity	This Mab cross-reacts with E. coli K1 polysaccharide but does not react with E. coli K92, group A and group C polysaccharides of Neisseria meningitidis. This Mab also reacts with N-propionylated group B polysaccharide
Proposed epitopes	The epitope consisted of α2-8 linked N-acetylneuraminic acid acid residues
IEDB Epitope	N/A
Proposed Utility	This antibody protected infant rats from bacteremia caused by Escherichia coli K1
Curator ID	AA + AS
Date of Curation	18-11-2010
References	PMC173242

Entry No. - 44 [TOP]

PolysacDB ID	1868
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It consists of a homopolymer of α(2-->8)-linked sialic acid residues
BCSDB Structure	7487
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Infected patient
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab HUFF
Antibody type and class	IgM
Assay System	ELISA, Rat protection assay
Cross-reactivity	This Mab cross-reacts with E. coli K1 polysaccharide but does not react with E. coli K92, group A and group C polysaccharides of Neisseria meningitidis. This Mab also reacts with N-propionylated group B polysaccharide
Proposed epitopes	The epitope consisted of α2-8 linked N-acetylneuraminic acid acid residues
IEDB Epitope	N/A
Proposed Utility	This antibody protected infant rats from bacteremia caused by Escherichia coli K1
Curator ID	AA + AS
Date of Curation	18-11-2010
References	PMC173242

Entry No. - 45 [TOP]

PolysacDB ID	1869
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It consists of a homopolymer of α(2-->8)-linked sialic acid residues
BCSDB Structure	7487
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Infected patient
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab LIP
Antibody type and class	IgM
Assay System	ELISA, Rat protection assay
Cross-reactivity	This Mab cross-reacts with E. coli K1 polysaccharide but does not react with E. coli K92, group A and group C polysaccharides of Neisseria meningitidis. This Mab also reacts with N-propionylated group B polysaccharide
Proposed epitopes	The epitope consisted of α2-8 linked N-acetylneuraminic acid acid residues
IEDB Epitope	N/A
Proposed Utility	This antibody protected infant rats from bacteremia caused by Escherichia coli K1
Curator ID	AA + AS
Date of Curation	19-11-2010
References	PMC173242

Entry No. - 46 [TOP]

PolysacDB ID	1870
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It consists of a homopolymer of α(2-->8)-linked sialic acid residues
BCSDB Structure	7487
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Infected patient
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab SLAD
Antibody type and class	IgM
Assay System	ELISA, Rat protection assay
Cross-reactivity	This Mab cross-reacts with E. coli K1 polysaccharide but does not react with E. coli K92, group A and group C polysaccharides of Neisseria meningitidis. This Mab also reacts with N-propionylated group B polysaccharide
Proposed epitopes	The epitope consisted of α2-8 linked N-acetylneuraminic acid acid residues
IEDB Epitope	N/A
Proposed Utility	This antibody protected infant rats from bacteremia caused by Escherichia coli K1
Curator ID	AA + AS
Date of Curation	19-11-2010
References	PMC173242

Entry No. - 47 [TOP]

PolysacDB ID	1871
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It consists of a homopolymer of α(2-->8)-linked sialic acid residues
BCSDB Structure	7487
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Tonsillar B cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 5E1
Antibody type and class	IgM
Assay System	ELISA
Cross-reactivity	This Mab reacts with E. coli K1 polysaccharide
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This antibody protected infant rats from bacteremia caused by Escherichia coli K1
Curator ID	AA + AS
Date of Curation	19-11-2010
References	1988519

Entry No. - 48 [TOP]

PolysacDB ID	1889
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It consists of a homopolymer of α(2-->8)-linked sialic acid residues
BCSDB Structure	7487
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab MB22
Antibody type and class	IgM
Assay System	Counter immunoelectrophoresis and slide agglutination tests
Cross-reactivity	This Mab was specific to group B polysaccharide and did not cross-react with Haemophilus influenza and Streptococcus pneumoniae. This Mab also cross-reacted with N. meningitidis group C polysaccharide antigen, an alpha (2->9)-linked homopolymer of sialic acid residues
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab can be used in culture identification.
Curator ID	AA + AS
Date of Curation	23-11-2010
References	PMC269298

Entry No. - 49 [TOP]

PolysacDB ID	1890
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It consists of a homopolymer of α(2-->8)-linked sialic acid residues
BCSDB Structure	7487
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 36
Antibody type and class	IgM
Assay System	Counter immunoelectrophoresis and slide agglutination tests
Cross-reactivity	This Mab was specific to group B polysaccharide and did not cross-react with Haemophilus influenza and Streptococcus pneumoniae
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab can be used in culture identification.
Curator ID	AA + AS
Date of Curation	23-11-2010
References	PMC269298

Entry No. - 50 [TOP]

PolysacDB ID	1891
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It consists of a homopolymer of α(2-->8)-linked sialic acid residues
BCSDB Structure	7487
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 62
Antibody type and class	IgM
Assay System	Counter immunoelectrophoresis and slide agglutination tests
Cross-reactivity	This Mab was specific to group B polysaccharide and did not cross-react with Haemophilus influenza and Streptococcus pneumoniae
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab can be used in culture identification.
Curator ID	AA + AS
Date of Curation	23-11-2010
References	PMC269298

Entry No. - 51 [TOP]

PolysacDB ID	1892
Carbohydrate Name	Capsular polysaccharide (Drugpedia)
Carbohydrate Class	Capsular polysaccharide
Microbe	Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia)
Basic Structure	It consists of a homopolymer of α(2-->8)-linked sialic acid residues
BCSDB Structure	7487
Proposed functions	It is an important virulence factor
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	Nil
Conjugation Method	Nil
Antibodies	Mab 85
Antibody type and class	IgM
Assay System	Counter immunoelectrophoresis and slide agglutination tests
Cross-reactivity	This Mab was specific to group B polysaccharide and did not cross-react with Haemophilus influenza and Streptococcus pneumoniae
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab can be used in culture identification.
Curator ID	AA + AS
Date of Curation	23-11-2010
References	PMC269298

Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020