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| PolysacDB ID | 1032 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor |
| BCSDB Structure | 127448 |
| Proposed functions | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature used to produce antibodies | Whole killed mycobacteria leprae cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab lam038 |
| Antibody type and class | IgM |
| Assay System | Sandwich ELISA |
| Cross-reactivity | This antibody cross-reacted with cross-reacted to a large number of mycobacterial species such as M. tuberculosis, M. bovis, M leprae, M. phlei and M. avium |
| Proposed epitopes | N\A |
| IEDB Epitope | N/A |
| Proposed Utility | These antibodies could be used to detect mycobacterial antigens in sputum |
| Curator ID | AA + AS |
| Date of Curation | 09-01-2010 |
| References | 2127645 |
| PolysacDB ID | 1033 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor |
| BCSDB Structure | 127448 |
| Proposed functions | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature used to produce antibodies | Whole killed mycobacteria leprae cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab lam204 |
| Antibody type and class | IgM |
| Assay System | Sandwich ELISA |
| Cross-reactivity | This antibody cross-reacted with cross-reacted to a large number of mycobacterial species such as M. tuberculosis, M. bovis, M leprae, M. phlei and M. avium |
| Proposed epitopes | N\A |
| IEDB Epitope | N/A |
| Proposed Utility | These antibodies could be used to detect mycobacterial antigens in sputum |
| Curator ID | AA + AS |
| Date of Curation | 09-01-2010 |
| References | 2127645 |
| PolysacDB ID | 1035 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor |
| BCSDB Structure | 127448 |
| Proposed functions | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature used to produce antibodies | Whole killed mycobacteria leprae cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab lam603 |
| Antibody type and class | IgM |
| Assay System | Sandwich ELISA |
| Cross-reactivity | This antibody cross-reacted with cross-reacted to a large number of mycobacterial species such as M. tuberculosis, M. bovis, M leprae, M. phlei and M. avium |
| Proposed epitopes | N\A |
| IEDB Epitope | N/A |
| Proposed Utility | These antibodies could be used to detect mycobacterial antigens in sputum |
| Curator ID | AA + AS |
| Date of Curation | 09-01-2010 |
| References | 2127645 |
| PolysacDB ID | 1036 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor |
| BCSDB Structure | 127448 |
| Proposed functions | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature used to produce antibodies | Whole killed mycobacteria leprae cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab Cs-35 |
| Antibody type and class | IgM |
| Assay System | Indirect and Competitive ELISA |
| Cross-reactivity | This antibody cross-reacted to M. tuberculosis and other Mycobacterium speices. |
| Proposed epitopes | β-D-Araf- (1-->2)-α-D-Araf-(1-->5)-α- D-Araf-(1-->5)-α-D-Araf within the branched hexa-Araf motif of mycobacterial arabinans |
| IEDB Epitope | 76797 |
| Proposed Utility | These antibodies could be used for screening of cell-wall mutants of mycobacteria lacking AG and AraLAM motifs and the recognition of biosynthetic intermediates of cell-wall polysaccharides unique to mycobacteria. |
| Curator ID | AA + AS |
| Date of Curation | 10-01-2010 |
| References | 12368438 |
| PolysacDB ID | 1631 |
| Carbohydrate Name | Lipoarabinomannan-B (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor |
| BCSDB Structure | N/A |
| Proposed functions | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature used to produce antibodies | Soluble extract of M. leprae |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab SAl.C7F |
| Antibody type and class | IgG1 |
| Assay System | Antigen capture ELISA, direct binding assay, |
| Cross-reactivity | This Mab was specific to M. leprae and did not cross-react with lipoarabinomannan from M. tuberculosis |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab becomes applicable for monitoring several individual M . Leprae antigens such as lipoarabinomannan |
| Curator ID | AA + AS |
| Date of Curation | 25-09-2010 |
| References | 2467001 |
| PolysacDB ID | 1632 |
| Carbohydrate Name | Lipoarabinomannan-B (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor |
| BCSDB Structure | N/A |
| Proposed functions | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature used to produce antibodies | Soluble extract of M. leprae |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab SAl.C11H |
| Antibody type and class | IgG1 |
| Assay System | Antigen capture ELISA, direct binding assay, |
| Cross-reactivity | This Mab was specific to M. leprae even though it cross-reacted to a little extent with lipoarabinomannan from M. tuberculosis |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab becomes applicable for monitoring several individual M . Leprae antigens such as lipoarabinomannan |
| Curator ID | AA + AS |
| Date of Curation | 26-09-2010 |
| References | 2467001 |
| PolysacDB ID | 1633 |
| Carbohydrate Name | Phenolic glycolipid antigen (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consisting of terminal 3,6-di-O-methyl glucose linked β1-->4 to 2,3-di-O-methyl rhamnose, which in turn is linked α1-->2 to 3-O-methyl rhamnose |
| BCSDB Structure | 114263 |
| Proposed functions | It has been proposed to protect pathogenic mycobacteria such as Mycobacterium lepraemurium from the host bactericidal activities in phagocytic cells |
| Antigenic Nature used to produce antibodies | Partially purified phenolic glycolipid from M. leprae |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab A1E |
| Antibody type and class | IgM |
| Assay System | ELISA, TLC autoradiography and immunofluorescence |
| Cross-reactivity | This Mab was specific to M. leprae glycolipid but cross-reacted with Mycobacterium terrae. Mycobacterium nonchromogenicum and Mycobacterium fortuitium |
| Proposed epitopes | Terminal 3,6-di-O-methyl glucose residues were proposed to be a part of the epitope |
| IEDB Epitope | 76895 |
| Proposed Utility | This Mab may provide more information on the structure of phenolic glycolipid of M. leprae and the localization of this antigen can be performed within infected lesions by immunofluorescence |
| Curator ID | AA + AS |
| Date of Curation | 26-09-2010 |
| References | PMC263407 |
| PolysacDB ID | 1634 |
| Carbohydrate Name | Phenolic glycolipid antigen (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consisting of terminal 3,6-di-O-methyl glucose linked β1-->4 to 2,3-di-O-methyl rhamnose, which in turn is linked α1-->2 to 3-O-methyl rhamnose |
| BCSDB Structure | 114263 |
| Proposed functions | It has been proposed to protect pathogenic mycobacteria such as Mycobacterium lepraemurium from the host bactericidal activities in phagocytic cells |
| Antigenic Nature used to produce antibodies | Partially purified phenolic glycolipid from M. leprae |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab |
| Antibody type and class | IgM |
| Assay System | ELISA, TLC autoradiography and immunofluorescence |
| Cross-reactivity | This Mab was specific to M. leprae glycolipid |
| Proposed epitopes | Terminal 3,6-di-O-methyl glucose residues were proposed to be a part of the epitope |
| IEDB Epitope | 76895 |
| Proposed Utility | This Mab may provide more information on the structure of phenolic glycolipid of M. leprae and the localization of this antigen can be performed within infected lesions by immunofluorescence |
| Curator ID | AA + AS |
| Date of Curation | 26-09-2010 |
| References | PMC263407 |
| PolysacDB ID | 1635 |
| Carbohydrate Name | Phenolic glycolipid antigen (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consisting of terminal 3,6-di-O-methyl glucose linked β1-->4 to 2,3-di-O-methyl rhamnose, which in turn is linked α1-->2 to 3-O-methyl rhamnose |
| BCSDB Structure | 114263 |
| Proposed functions | It has been proposed to protect pathogenic mycobacteria such as Mycobacterium lepraemurium from the host bactericidal activities in phagocytic cells |
| Antigenic Nature used to produce antibodies | Partially purified phenolic glycolipid from M. leprae |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab A2A |
| Antibody type and class | IgM |
| Assay System | ELISA, TLC autoradiography and immunofluorescence |
| Cross-reactivity | This Mab was specific to M. leprae glycolipid |
| Proposed epitopes | Terminal 3,6-di-O-methyl glucose residues were proposed to be a part of the epitope |
| IEDB Epitope | 76895 |
| Proposed Utility | This Mab may provide more information on the structure of phenolic glycolipid of M. leprae and the localization of this antigen can be performed within infected lesions by immunofluorescence |
| Curator ID | AA + AS |
| Date of Curation | 26-09-2010 |
| References | PMC263407 |
| PolysacDB ID | 1636 |
| Carbohydrate Name | Phenolic glycolipid antigen (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consisting of terminal 3,6-di-O-methyl glucose linked β1-->4 to 2,3-di-O-methyl rhamnose, which in turn is linked α1-->2 to 3-O-methyl rhamnose |
| BCSDB Structure | 114263 |
| Proposed functions | It has been proposed to protect pathogenic mycobacteria such as Mycobacterium lepraemurium from the host bactericidal activities in phagocytic cells |
| Antigenic Nature used to produce antibodies | Partially purified phenolic glycolipid from M. leprae |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab A3H |
| Antibody type and class | IgM |
| Assay System | ELISA, TLC autoradiography and immunofluorescence |
| Cross-reactivity | This Mab was specific to M. leprae glycolipid |
| Proposed epitopes | Terminal 3,6-di-O-methyl glucose residues were proposed to be a part of the epitope |
| IEDB Epitope | 76895 |
| Proposed Utility | This Mab may provide more information on the structure of phenolic glycolipid of M. leprae and the localization of this antigen can be performed within infected lesions by immunofluorescence |
| Curator ID | AA + AS |
| Date of Curation | 26-09-2010 |
| References | PMC263407 |
| PolysacDB ID | 1637 |
| Carbohydrate Name | Phenolic glycolipid antigen (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consisting of terminal 3,6-di-O-methyl glucose linked β1-->4 to 2,3-di-O-methyl rhamnose, which in turn is linked α1-->2 to 3-O-methyl rhamnose |
| BCSDB Structure | 114263 |
| Proposed functions | It has been proposed to protect pathogenic mycobacteria such as Mycobacterium lepraemurium from the host bactericidal activities in phagocytic cells |
| Antigenic Nature used to produce antibodies | Partially purified phenolic glycolipid from M. leprae |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab B2G |
| Antibody type and class | IgM |
| Assay System | ELISA, TLC autoradiography and immunofluorescence |
| Cross-reactivity | This Mab was specific to M. leprae glycolipid |
| Proposed epitopes | Terminal 3,6-di-O-methyl glucose residues were proposed to be a part of the epitope |
| IEDB Epitope | 76895 |
| Proposed Utility | This Mab may provide more information on the structure of phenolic glycolipid of M. leprae and the localization of this antigen can be performed within infected lesions by immunofluorescence |
| Curator ID | AA + AS |
| Date of Curation | 26-09-2010 |
| References | PMC263407 |
| PolysacDB ID | 1638 |
| Carbohydrate Name | Phenolic glycolipid antigen (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consisting of terminal 3,6-di-O-methyl glucose linked β1-->4 to 2,3-di-O-methyl rhamnose, which in turn is linked α1-->2 to 3-O-methyl rhamnose |
| BCSDB Structure | 114263 |
| Proposed functions | It has been proposed to protect pathogenic mycobacteria such as Mycobacterium lepraemurium from the host bactericidal activities in phagocytic cells |
| Antigenic Nature used to produce antibodies | Partially purified phenolic glycolipid from M. leprae |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab B5B |
| Antibody type and class | IgM |
| Assay System | ELISA, TLC autoradiography and immunofluorescence |
| Cross-reactivity | This Mab was specific to M. leprae glycolipid |
| Proposed epitopes | Terminal 3,6-di-O-methyl glucose residues were proposed to be a part of the epitope |
| IEDB Epitope | 76895 |
| Proposed Utility | This Mab may provide more information on the structure of phenolic glycolipid of M. leprae and the localization of this antigen can be performed within infected lesions by immunofluorescence |
| Curator ID | AA + AS |
| Date of Curation | 26-09-2010 |
| References | PMC263407 |
| PolysacDB ID | 1639 |
| Carbohydrate Name | Phenolic glycolipid antigen (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consisting of terminal 3,6-di-O-methyl glucose linked β1-->4 to 2,3-di-O-methyl rhamnose, which in turn is linked α1-->2 to 3-O-methyl rhamnose |
| BCSDB Structure | 114263 |
| Proposed functions | It has been proposed to protect pathogenic mycobacteria such as Mycobacterium lepraemurium from the host bactericidal activities in phagocytic cells |
| Antigenic Nature used to produce antibodies | Partially purified phenolic glycolipid from M. leprae |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab B5H |
| Antibody type and class | IgM |
| Assay System | ELISA, TLC autoradiography and immunofluorescence |
| Cross-reactivity | This Mab was specific to M. leprae glycolipid |
| Proposed epitopes | Terminal 3,6-di-O-methyl glucose residues were proposed to be a part of the epitope |
| IEDB Epitope | 76895 |
| Proposed Utility | This Mab may provide more information on the structure of phenolic glycolipid of M. leprae and the localization of this antigen can be performed within infected lesions by immunofluorescence |
| Curator ID | AA + AS |
| Date of Curation | 26-09-2010 |
| References | PMC263407 |
| PolysacDB ID | 1640 |
| Carbohydrate Name | Phenolic glycolipid antigen (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consisting of terminal 3,6-di-O-methyl glucose linked β1-->4 to 2,3-di-O-methyl rhamnose, which in turn is linked α1-->2 to 3-O-methyl rhamnose |
| BCSDB Structure | 114263 |
| Proposed functions | It has been proposed to protect pathogenic mycobacteria such as Mycobacterium lepraemurium from the host bactericidal activities in phagocytic cells |
| Antigenic Nature used to produce antibodies | Partially purified phenolic glycolipid from M. leprae |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab B8F |
| Antibody type and class | IgM |
| Assay System | ELISA, TLC autoradiography and immunofluorescence |
| Cross-reactivity | This Mab was specific to M. leprae glycolipid |
| Proposed epitopes | Terminal 3,6-di-O-methyl glucose residues were proposed to be a part of the epitope |
| IEDB Epitope | 76895 |
| Proposed Utility | This Mab may provide more information on the structure of phenolic glycolipid of M. leprae and the localization of this antigen can be performed within infected lesions by immunofluorescence |
| Curator ID | AA + AS |
| Date of Curation | 26-09-2010 |
| References | PMC263407 |
| PolysacDB ID | 1641 |
| Carbohydrate Name | Phenolic glycolipid antigen (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consisting of terminal 3,6-di-O-methyl glucose linked β1-->4 to 2,3-di-O-methyl rhamnose, which in turn is linked α1-->2 to 3-O-methyl rhamnose |
| BCSDB Structure | 114263 |
| Proposed functions | It has been proposed to protect pathogenic mycobacteria such as Mycobacterium lepraemurium from the host bactericidal activities in phagocytic cells |
| Antigenic Nature used to produce antibodies | Partially purified phenolic glycolipid from M. leprae |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab B9D |
| Antibody type and class | IgM |
| Assay System | ELISA, TLC autoradiography and immunofluorescence |
| Cross-reactivity | This Mab cross-reacted with M. kansasii phenolic glycolipid and cross-reacted with whole cells of 20 mycobacterial strains |
| Proposed epitopes | Terminal 3,6-di-O-methyl glucose residues were proposed to be a part of the epitope |
| IEDB Epitope | 76895 |
| Proposed Utility | This Mab may provide more information on the structure of phenolic glycolipid of M. leprae and the localization of this antigen can be performed within infected lesions by immunofluorescence |
| Curator ID | AA + AS |
| Date of Curation | 26-09-2010 |
| References | PMC263407 |
| PolysacDB ID | 1642 |
| Carbohydrate Name | Phenolic glycolipid antigen (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consisting of terminal 3,6-di-O-methyl glucose linked β1-->4 to 2,3-di-O-methyl rhamnose, which in turn is linked α1-->2 to 3-O-methyl rhamnose |
| BCSDB Structure | 114263 |
| Proposed functions | It has been proposed to protect pathogenic mycobacteria such as Mycobacterium lepraemurium from the host bactericidal activities in phagocytic cells |
| Antigenic Nature used to produce antibodies | Partially purified phenolic glycolipid from M. leprae |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab B1OH |
| Antibody type and class | IgM |
| Assay System | ELISA, TLC autoradiography and immunofluorescence |
| Cross-reactivity | This Mab was specific to M. leprae glycolipid |
| Proposed epitopes | Terminal 3,6-di-O-methyl glucose residues were proposed to be a part of the epitope |
| IEDB Epitope | 76895 |
| Proposed Utility | This Mab may provide more information on the structure of phenolic glycolipid of M. leprae and the localization of this antigen can be performed within infected lesions by immunofluorescence |
| Curator ID | AA + AS |
| Date of Curation | 27-09-2010 |
| References | PMC263407 |
| PolysacDB ID | 1643 |
| Carbohydrate Name | Arabinogalactan (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | N/A |
| BCSDB Structure | N/A |
| Proposed functions | N/A |
| Antigenic Nature used to produce antibodies | A combination of M. leprae 30KS and 1OKP |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab IVD2 |
| Antibody type and class | IgM |
| Assay System | ELISA, immunoblotting and immunofluorescence |
| Cross-reactivity | This Mab was highly cross-reactive and cross-reacted with 19 different strains of mycobacteria |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may help in epitope structure validation |
| Curator ID | AA + AS |
| Date of Curation | 27-09-2010 |
| References | PMC347507 |
| PolysacDB ID | 1644 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed functions | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab 901 |
| Antibody type and class | IgG3 |
| Assay System | ELISA |
| Cross-reactivity | This Mab cross-reacted with M. tuberculosis |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 27-09-2010 |
| References | PMC259992 |
| PolysacDB ID | 1645 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed functions | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab 903 |
| Antibody type and class | IgG3 |
| Assay System | ELISA |
| Cross-reactivity | This Mab cross-reacted with M. tuberculosis |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 27-09-2010 |
| References | PMC259992 |
| PolysacDB ID | 1646 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed functions | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab 904 |
| Antibody type and class | IgG3 |
| Assay System | ELISA |
| Cross-reactivity | This Mab cross-reacted with M. tuberculosis |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 27-09-2010 |
| References | PMC259992 |
| PolysacDB ID | 1647 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed functions | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab 906 |
| Antibody type and class | IgG3 |
| Assay System | ELISA |
| Cross-reactivity | This Mab cross-reacted with M. tuberculosis |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 29-09-2010 |
| References | PMC259992 |
| PolysacDB ID | 1648 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed functions | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab 922 |
| Antibody type and class | IgG3 |
| Assay System | ELISA |
| Cross-reactivity | This Mab cross-reacted with M. tuberculosis |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 29-09-2010 |
| References | PMC259992 |
| PolysacDB ID | 1649 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed functions | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab 908 |
| Antibody type and class | IgG3 |
| Assay System | ELISA |
| Cross-reactivity | This Mab cross-reacted with M. tuberculosis |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 29-09-2010 |
| References | PMC259992 |
| PolysacDB ID | 1650 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed functions | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab 920 |
| Antibody type and class | IgG3 |
| Assay System | ELISA |
| Cross-reactivity | This Mab cross-reacted with M. tuberculosis |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 29-09-2010 |
| References | PMC259992 |
| PolysacDB ID | 1651 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed functions | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature used to produce antibodies | A combination of M. leprae 30KS and 1OKP |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab A6C |
| Antibody type and class | IgG1 |
| Assay System | ELISA, immunoblotting |
| Cross-reactivity | This Mab was specific for M. leprae LAM |
| Proposed epitopes | α(1-->5)-linked arabinofuranosyl residues seemed to be a part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 29-09-2010 |
| References | PMC259992 |
| PolysacDB ID | 1652 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed functions | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature used to produce antibodies | A combination of M. leprae 30KS and 1OKP |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab A10G |
| Antibody type and class | IgG1 |
| Assay System | ELISA, immunoblotting |
| Cross-reactivity | This Mab was specific for M. leprae LAM |
| Proposed epitopes | α(1-->5)-linked arabinofuranosyl residues seemed to be a part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 29-09-2010 |
| References | PMC259992 |
| PolysacDB ID | 1653 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed functions | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature used to produce antibodies | A combination of M. leprae 30KS and 1OKP |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab A11C |
| Antibody type and class | IgG1 |
| Assay System | ELISA, immunoblotting |
| Cross-reactivity | This Mab was specific for M. leprae LAM |
| Proposed epitopes | α(1-->5)-linked arabinofuranosyl residues seemed to be a part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 29-09-2010 |
| References | PMC259992 |
| PolysacDB ID | 1654 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed functions | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature used to produce antibodies | A combination of M. leprae 30KS and 1OKP |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab A12B |
| Antibody type and class | IgG1 |
| Assay System | ELISA, immunoblotting |
| Cross-reactivity | This Mab was specific for M. leprae LAM |
| Proposed epitopes | α(1-->5)-linked arabinofuranosyl residues seemed to be a part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 30-09-2010 |
| References | PMC259992 |
| PolysacDB ID | 1655 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed functions | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature used to produce antibodies | A combination of M. leprae 30KS and 1OKP |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab A12C |
| Antibody type and class | IgG1 |
| Assay System | ELISA, immunoblotting |
| Cross-reactivity | This Mab was specific for M. leprae LAM |
| Proposed epitopes | α(1-->5)-linked arabinofuranosyl residues seemed to be a part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 30-09-2010 |
| References | PMC259992 |
| PolysacDB ID | 1656 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed functions | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature used to produce antibodies | A combination of M. leprae 30KS and 1OKP |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab A12D |
| Antibody type and class | IgG1 |
| Assay System | ELISA, immunoblotting |
| Cross-reactivity | This Mab was specific for M. leprae LAM |
| Proposed epitopes | α(1-->5)-linked arabinofuranosyl residues seemed to be a part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 30-09-2010 |
| References | PMC259992 |
| PolysacDB ID | 1657 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed functions | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature used to produce antibodies | A combination of M. leprae 30KS and 1OKP |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab B10E |
| Antibody type and class | IgG1 |
| Assay System | ELISA, immunoblotting |
| Cross-reactivity | This Mab was specific for M. leprae LAM |
| Proposed epitopes | α(1-->5)-linked arabinofuranosyl residues seemed to be a part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 01-10-2010 |
| References | PMC259992 |
| PolysacDB ID | 1658 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed functions | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature used to produce antibodies | A combination of M. leprae 30KS and 1OKP |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab C94 |
| Antibody type and class | IgG1 |
| Assay System | ELISA, immunoblotting |
| Cross-reactivity | This Mab was specific for M. leprae LAM |
| Proposed epitopes | α(1-->5)-linked arabinofuranosyl residues seemed to be a part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 01-10-2010 |
| References | PMC259992 |
| PolysacDB ID | 1659 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed functions | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature used to produce antibodies | A combination of M. leprae 30KS and 1OKP |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab D1F |
| Antibody type and class | IgG1 |
| Assay System | ELISA, immunoblotting |
| Cross-reactivity | This Mab was specific for M. leprae LAM |
| Proposed epitopes | α(1-->5)-linked arabinofuranosyl residues seemed to be a part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 01-10-2010 |
| References | PMC259992 |
| PolysacDB ID | 1660 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed functions | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature used to produce antibodies | A combination of M. leprae 30KS and 1OKP |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab D11E |
| Antibody type and class | IgG1 |
| Assay System | ELISA, immunoblotting |
| Cross-reactivity | This Mab was specific for M. leprae LAM |
| Proposed epitopes | α(1-->5)-linked arabinofuranosyl residues seemed to be a part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 01-10-2010 |
| References | PMC259992 |
| PolysacDB ID | 1661 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed functions | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature used to produce antibodies | A combination of M. leprae 30KS and 1OKP |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab D11G |
| Antibody type and class | IgG1 |
| Assay System | ELISA, immunoblotting |
| Cross-reactivity | This Mab was specific for M. leprae LAM |
| Proposed epitopes | α(1-->5)-linked arabinofuranosyl residues seemed to be a part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 01-10-2010 |
| References | PMC259992 |
| PolysacDB ID | 1662 |
| Carbohydrate Name | Lipoarabinomannan (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate |
| BCSDB Structure | 127448 |
| Proposed functions | T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages |
| Antigenic Nature used to produce antibodies | A combination of M. leprae 30KS and 1OKP |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab C11H |
| Antibody type and class | IgG1 |
| Assay System | ELISA, immunoblotting |
| Cross-reactivity | This Mab was specific for M. leprae LAM |
| Proposed epitopes | α(1-->5)-linked arabinofuranosyl residues seemed to be a part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help in the structure elucidation of lipoarabinomanna |
| Curator ID | AA + AS |
| Date of Curation | 01-10-2010 |
| References | PMC259992 |
| PolysacDB ID | 1695 |
| Carbohydrate Name | 4.5-6 KDa antigen (Drugpedia) |
| Carbohydrate Class | Glycoprotein |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | N/A |
| BCSDB Structure | N/A |
| Proposed functions | N/A |
| Antigenic Nature used to produce antibodies | Soluble sonicate |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab L3 |
| Antibody type and class | IgM |
| Assay System | ELISA, immunodiffusion, immunoblotting and inhibition assays |
| Cross-reactivity | This Mab was highly cross-reactive and reacted with all 14 mycobacterial strains except for M. gastris |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used for antigen identification and isolation |
| Curator ID | AA + AS |
| Date of Curation | 09-10-2010 |
| References | 2415603 |
| PolysacDB ID | 1696 |
| Carbohydrate Name | 4.5-6 KDa antigen (Drugpedia) |
| Carbohydrate Class | Glycoprotein |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | N/A |
| BCSDB Structure | N/A |
| Proposed functions | N/A |
| Antigenic Nature used to produce antibodies | Soluble sonicate |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab L4 |
| Antibody type and class | IgG2a |
| Assay System | ELISA, immunodiffusion, immunoblotting and inhibition assays |
| Cross-reactivity | This Mab was highly cross-reactive and reacted with all 14 mycobacterial strains except for M. vaccae and M. chelonei |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used for antigen identification and isolation |
| Curator ID | AA + AS |
| Date of Curation | 09-10-2010 |
| References | 2415603 |
| PolysacDB ID | 1697 |
| Carbohydrate Name | 4.5-6 KDa antigen (Drugpedia) |
| Carbohydrate Class | Glycoprotein |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | N/A |
| BCSDB Structure | N/A |
| Proposed functions | N/A |
| Antigenic Nature used to produce antibodies | Soluble sonicate |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab B6 |
| Antibody type and class | IgG3 |
| Assay System | ELISA, immunodiffusion, immunoblotting and inhibition assays |
| Cross-reactivity | This Mab was highly cross-reactive and reacted with all 14 mycobacterial strains except for M. vaccae and M. chelonei |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used for antigen identification and isolation |
| Curator ID | AA + AS |
| Date of Curation | 09-10-2010 |
| References | 2415603 |
| PolysacDB ID | 1698 |
| Carbohydrate Name | 30-40 KDa antigen (Drugpedia) |
| Carbohydrate Class | Glycoprotein |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | N/A |
| BCSDB Structure | N/A |
| Proposed functions | N/A |
| Antigenic Nature used to produce antibodies | Soluble sonicate |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab L1 |
| Antibody type and class | IgM |
| Assay System | ELISA, immunodiffusion, immunoblotting and inhibition assays |
| Cross-reactivity | This Mab was highly cross-reactive and reacted with all 14 mycobacterial strains except for M. vaccae |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used for antigen identification and isolation |
| Curator ID | AA + AS |
| Date of Curation | 10-10-2010 |
| References | 2415603 |
| PolysacDB ID | 1699 |
| Carbohydrate Name | 30-40 KDa antigen (Drugpedia) |
| Carbohydrate Class | Glycoprotein |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | N/A |
| BCSDB Structure | N/A |
| Proposed functions | N/A |
| Antigenic Nature used to produce antibodies | Soluble sonicate |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab L9 |
| Antibody type and class | IgG3 |
| Assay System | ELISA, immunodiffusion, immunoblotting and inhibition assays |
| Cross-reactivity | This Mab was highly cross-reactive and reacted with all 14 mycobacterial strains except for M. vaccae and M. scrofufaceurn |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used for antigen identification and isolation |
| Curator ID | AA + AS |
| Date of Curation | 10-10-2010 |
| References | 2415603 |
| PolysacDB ID | 1700 |
| Carbohydrate Name | 30-40 KDa antigen (Drugpedia) |
| Carbohydrate Class | Glycoprotein |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | N/A |
| BCSDB Structure | N/A |
| Proposed functions | N/A |
| Antigenic Nature used to produce antibodies | Soluble sonicate |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab L10 |
| Antibody type and class | IgG3 |
| Assay System | ELISA, immunodiffusion, immunoblotting and inhibition assays |
| Cross-reactivity | This Mab was highly cross-reactive and reacted with all 14 mycobacterial strains except for M. vaccae and M. scrofufaceurn |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab can be used for antigen identification and isolation |
| Curator ID | AA + AS |
| Date of Curation | 10-10-2010 |
| References | 2415603 |
| PolysacDB ID | 1711 |
| Carbohydrate Name | Unknown carbohydrate (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | N/A |
| BCSDB Structure | N/A |
| Proposed functions | N/A |
| Antigenic Nature used to produce antibodies | Supernatant fraction of sonicated M. leprae |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab ML02 |
| Antibody type and class | IgG3 |
| Assay System | Radioimmunoassays, immunoblotting |
| Cross-reactivity | This Mab was highly cross-reactive and cross-reacted with all ten mycobacterial strains studied except for M. scrofulaceum, M. neoaurum and M. lepraemurium |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may represent a novel valuable diagnostic reagent as well as tool for the purification of antigens which could be explored towards prophylactic or therapeutic immunization against leprosy. |
| Curator ID | AA + AS |
| Date of Curation | 13-10-2010 |
| References | PMC1536026 |
| PolysacDB ID | 1712 |
| Carbohydrate Name | Unknown carbohydrate (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | N/A |
| BCSDB Structure | N/A |
| Proposed functions | N/A |
| Antigenic Nature used to produce antibodies | Supernatant fraction of sonicated M. leprae |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab ML09 |
| Antibody type and class | IgG3 |
| Assay System | Radioimmunoassays, immunoblotting |
| Cross-reactivity | This Mab was highly cross-reactive and cross-reacted with all ten mycobacterial strains studied except for M. scrofulaceum, M. neoaurum and M. lepraemurium |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may represent a novel valuable diagnostic reagent as well as tool for the purification of antigens which could be explored towards prophylactic or therapeutic immunization against leprosy. |
| Curator ID | AA + AS |
| Date of Curation | 13-10-2010 |
| References | PMC1536026 |
| PolysacDB ID | 1713 |
| Carbohydrate Name | Unknown carbohydrate (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | N/A |
| BCSDB Structure | N/A |
| Proposed functions | N/A |
| Antigenic Nature used to produce antibodies | Supernatant fraction of sonicated M. leprae |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab ML34 |
| Antibody type and class | IgM |
| Assay System | Radioimmunoassays, immunoblotting |
| Cross-reactivity | This Mab was highly cross-reactive and cross-reacted with all ten mycobacterial strains studied except for M. avium, M. neoaurum, M. kansasii and M strain W |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may represent a novel valuable diagnostic reagent as well as tool for the purification of antigens which could be explored towards prophylactic or therapeutic immunization against leprosy. |
| Curator ID | AA + AS |
| Date of Curation | 13-10-2010 |
| References | PMC1536026 |
| PolysacDB ID | 1728 |
| Carbohydrate Name | Phenolic glycolipid-I (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose |
| BCSDB Structure | N/A |
| Proposed functions | It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy |
| Antigenic Nature used to produce antibodies | Phenolic glycolipid-1 and heat-killed M. leprae |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab III603.8 |
| Antibody type and class | IgM |
| Assay System | ELISA |
| Cross-reactivity | This Mab reacted with deacylated Phenolic glycolipid-1[ PGL-I (PGL-I OH )], but did not bind to PGL antigens from M. kansasii (mycoside A), M. bovis (deacylated mycosideB), and M. tuberculosis (PGL-Tb OH ) |
| Proposed epitopes | The outer monosaccharide, disaccharide and the trisaccharide all contributed to the epitope recognized by this Mab |
| IEDB Epitope | 76905 |
| Proposed Utility | This Mab was used for the development of peptide mimotopes resembling the carbohydrate structures recognized by this Mab |
| Curator ID | AA + AS |
| Date of Curation | 16-10-2010 |
| References | 15094167 |
| PolysacDB ID | 1729 |
| Carbohydrate Name | Phenolic glycolipid-I (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose |
| BCSDB Structure | N/A |
| Proposed functions | It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy |
| Antigenic Nature used to produce antibodies | Phenolic glycolipid-1 and heat-killed M. leprae |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab VI703 |
| Antibody type and class | IgG3 |
| Assay System | ELISA |
| Cross-reactivity | This Mab reacted with deacylated Phenolic glycolipid-1[ PGL-I (PGL-I OH )], but did not bind to PGL antigens from M. kansasii (mycoside A), M. bovis (deacylated mycosideB), and M. tuberculosis (PGL-Tb OH ) |
| Proposed epitopes | The outer monosaccharide, disaccharide and the trisaccharide all contributed to the epitope recognized by this Mab |
| IEDB Epitope | 76905 |
| Proposed Utility | This Mab was used for the development of peptide mimotopes resembling the carbohydrate structures recognized by this Mab |
| Curator ID | AA + AS |
| Date of Curation | 17-10-2010 |
| References | 15094167 |
| PolysacDB ID | 1730 |
| Carbohydrate Name | Phenolic glycolipid-I (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose |
| BCSDB Structure | N/A |
| Proposed functions | It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab 1-21 |
| Antibody type and class | N/A |
| Assay System | Inhibitory ELISA |
| Cross-reactivity | This Mab recognized the outer (nonreducing end) monosaccharide of the trisaccharide chain of PGL-I |
| Proposed epitopes | N/A |
| IEDB Epitope | 76905 |
| Proposed Utility | This Mab promises to be an effective tool for the immunological study of PGL-I and the clinical assessment of leprosy |
| Curator ID | AA + AS |
| Date of Curation | 17-10-2010 |
| References | 9465158 |
| PolysacDB ID | 1731 |
| Carbohydrate Name | Phenolic glycolipid-I (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose |
| BCSDB Structure | N/A |
| Proposed functions | It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab 1-24 |
| Antibody type and class | N/A |
| Assay System | Inhibitory ELISA |
| Cross-reactivity | This Mab recognized the outer (nonreducing end) monosaccharide of the trisaccharide chain of PGL-I |
| Proposed epitopes | N/A |
| IEDB Epitope | 76905 |
| Proposed Utility | This Mab promises to be an effective tool for the immunological study of PGL-I and the clinical assessment of leprosy |
| Curator ID | AA + AS |
| Date of Curation | 17-10-2010 |
| References | 9465158 |
| PolysacDB ID | 1732 |
| Carbohydrate Name | Phenolic glycolipid-I (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose |
| BCSDB Structure | N/A |
| Proposed functions | It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab 1-25 |
| Antibody type and class | N/A |
| Assay System | Inhibitory ELISA |
| Cross-reactivity | This Mab recognized the outer (nonreducing end) monosaccharide of the trisaccharide chain of PGL-I |
| Proposed epitopes | N/A |
| IEDB Epitope | 76905 |
| Proposed Utility | This Mab promises to be an effective tool for the immunological study of PGL-I and the clinical assessment of leprosy |
| Curator ID | AA + AS |
| Date of Curation | 17-10-2010 |
| References | 9465158 |
| PolysacDB ID | 1733 |
| Carbohydrate Name | Phenolic glycolipid-I (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose |
| BCSDB Structure | N/A |
| Proposed functions | It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab ml 6A12 |
| Antibody type and class | N/A |
| Assay System | Inhibitory ELISA |
| Cross-reactivity | This Mab recognized the outer disaccharide of the trisaccharide chain of PGL-I |
| Proposed epitopes | N/A |
| IEDB Epitope | 76905 |
| Proposed Utility | This Mab promises to be an effective tool for the immunological study of PGL-I and the clinical assessment of leprosy |
| Curator ID | AA + AS |
| Date of Curation | 18-10-2010 |
| References | 9465158 |
| PolysacDB ID | 1734 |
| Carbohydrate Name | Phenolic glycolipid-I (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose |
| BCSDB Structure | N/A |
| Proposed functions | It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab ml 8A2 |
| Antibody type and class | N/A |
| Assay System | Inhibitory ELISA |
| Cross-reactivity | This Mab recognized the outer disaccharide of the trisaccharide chain of PGL-I |
| Proposed epitopes | N/A |
| IEDB Epitope | 76905 |
| Proposed Utility | This Mab promises to be an effective tool for the immunological study of PGL-I and the clinical assessment of leprosy |
| Curator ID | AA + AS |
| Date of Curation | 18-10-2010 |
| References | 9465158 |
| PolysacDB ID | 1735 |
| Carbohydrate Name | Phenolic glycolipid-I (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose |
| BCSDB Structure | N/A |
| Proposed functions | It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab ml 8B2 |
| Antibody type and class | N/A |
| Assay System | Inhibitory ELISA |
| Cross-reactivity | This Mab recognized the outer disaccharide of the trisaccharide chain of PGL-I |
| Proposed epitopes | N/A |
| IEDB Epitope | 76905 |
| Proposed Utility | This Mab promises to be an effective tool for the immunological study of PGL-I and the clinical assessment of leprosy |
| Curator ID | AA + AS |
| Date of Curation | 18-10-2010 |
| References | 9465158 |
| PolysacDB ID | 1736 |
| Carbohydrate Name | Phenolic glycolipid-I (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose |
| BCSDB Structure | N/A |
| Proposed functions | It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab PG2 B8F |
| Antibody type and class | N/A |
| Assay System | Inhibitory ELISA |
| Cross-reactivity | This Mab recognized the outer disaccharide of the trisaccharide chain of PGL-I |
| Proposed epitopes | N/A |
| IEDB Epitope | 76905 |
| Proposed Utility | This Mab promises to be an effective tool for the immunological study of PGL-I and the clinical assessment of leprosy |
| Curator ID | AA + AS |
| Date of Curation | 18-10-2010 |
| References | 9465158 |
| PolysacDB ID | 1737 |
| Carbohydrate Name | Phenolic glycolipid-I (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose |
| BCSDB Structure | N/A |
| Proposed functions | It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab F47-21-3 |
| Antibody type and class | N/A |
| Assay System | Inhibitory ELISA |
| Cross-reactivity | This Mab recognized the outer disaccharide of the trisaccharide chain of PGL-I and also some parts of an unknown sugar |
| Proposed epitopes | N/A |
| IEDB Epitope | 76905 |
| Proposed Utility | This Mab promises to be an effective tool for the immunological study of PGL-I and the clinical assessment of leprosy |
| Curator ID | AA + AS |
| Date of Curation | 19-10-2010 |
| References | 9465158 |
| PolysacDB ID | 1738 |
| Carbohydrate Name | Phenolic glycolipid-I (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose |
| BCSDB Structure | N/A |
| Proposed functions | It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab SF 1 |
| Antibody type and class | N/A |
| Assay System | Inhibitory ELISA |
| Cross-reactivity | This Mab recognized the outer trisaccharide chain of PGL-I |
| Proposed epitopes | N/A |
| IEDB Epitope | 76905 |
| Proposed Utility | This Mab promises to be an effective tool for the immunological study of PGL-I and the clinical assessment of leprosy |
| Curator ID | AA + AS |
| Date of Curation | 19-10-2010 |
| References | 9465158 |
| PolysacDB ID | 1739 |
| Carbohydrate Name | Phenolic glycolipid-I (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose |
| BCSDB Structure | N/A |
| Proposed functions | It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab 3D1-A9 |
| Antibody type and class | N/A |
| Assay System | Inhibitory ELISA |
| Cross-reactivity | This Mab recognized the phenol group and the structure around the branching point on the carrier protein in addition to the trisaccharide |
| Proposed epitopes | N/A |
| IEDB Epitope | 76905 |
| Proposed Utility | This Mab promises to be an effective tool for the immunological study of PGL-I and the clinical assessment of leprosy |
| Curator ID | AA + AS |
| Date of Curation | 19-10-2010 |
| References | 9465158 |
| PolysacDB ID | 1740 |
| Carbohydrate Name | Phenolic glycolipid-I (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose |
| BCSDB Structure | N/A |
| Proposed functions | It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab DZ 1 |
| Antibody type and class | N/A |
| Assay System | Inhibitory ELISA |
| Cross-reactivity | This Mab recognized the inner (reducing end) disaccharide chain of the trisaccharide part of PGL-1 |
| Proposed epitopes | N/A |
| IEDB Epitope | 76905 |
| Proposed Utility | This Mab promises to be an effective tool for the immunological study of PGL-I and the clinical assessment of leprosy |
| Curator ID | AA + AS |
| Date of Curation | 20-10-2010 |
| References | 9465158 |
| PolysacDB ID | 1741 |
| Carbohydrate Name | Phenolic glycolipid-I (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose |
| BCSDB Structure | N/A |
| Proposed functions | It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab 2G3-A8 |
| Antibody type and class | N/A |
| Assay System | Inhibitory ELISA |
| Cross-reactivity | MAb 2G3-A8 recognized the inner monosaccharide, phenol group and the structure around the branching point on the carrier protein |
| Proposed epitopes | N/A |
| IEDB Epitope | 76905 |
| Proposed Utility | This Mab promises to be an effective tool for the immunological study of PGL-I and the clinical assessment of leprosy |
| Curator ID | AA + AS |
| Date of Curation | 20-10-2010 |
| References | 9465158 |
| PolysacDB ID | 1742 |
| Carbohydrate Name | Phenolic glycolipid-I (Drugpedia) |
| Carbohydrate Class | Glycolipid |
| Microbe | Mycobacterium leprae (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose |
| BCSDB Structure | N/A |
| Proposed functions | It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Polysera |
| Antibody type and class | IgM |
| Assay System | ELISA |
| Cross-reactivity | The antisera cross-reacted withserovars 5, 12, 18, 20, 23, 24, and 28 of M. avium-M. intracellulare-M. scrofulaceum serocomplex |
| Proposed epitopes | The trisaccharide appendages of the phenolic glycolipids seemed to be a part of the epitope |
| IEDB Epitope | 76905 |
| Proposed Utility | A specific assay for IgM activity to the specific M. leprae glycolipid, particularly in the preclinical state of the lepromatous form of the disease, may enable earlier chemotherapy and thereby prevent deformity and eliminate the infectious reservoir |
| Curator ID | AA + AS |
| Date of Curation | 20-10-2010 |
| References | PMC264610 |
|
Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020 |