PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID1619
Carbohydrate NameLipooligosaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeMoraxella catarrhalis serotype C   (NCBI Taxonomy)   (Drugpedia)
Basic StructureLOS consists of an oligosaccharide and lipid A and is similar to the lipopolysaccharide (LPS) of gramnegative enteric pathogens, but it lacks the O-antigenic side chain of repeating units characteristic of classical LPS. The oligosaccharide part consists of the following residues : α-D-Galp-(1-->4)-β-D-Galp-(1-->4)-α-D-Glcp-(1-->2)-β-D-Glcp-(1-->6)-α-D-Glcp [branched to β-D-Galp-(1-->4)-α-D-GlcpNAc-(1-->2)-β-D-Glcp-(1-->4)] and [branched to β-D-Glcp-(1-->3)] -(1-->5)-α-Kdop [branched to Kdop-(2-->4)]
BCSDB Structure22728
Proposed functionsMoracella lipooligosaccharide is a potential virulence factor
Antigenic Nature used to produce antibodiesWhole cells
Carrier NameNil
Conjugation MethodNil
AntibodiesPolysera
Antibody type and classN/A
Assay SystemELISA and immunoblotting
Cross-reactivityThis antisera cross-reacted with Serotype A LPS
Proposed epitopesA terminal β-D-Gal-(1-->4)-α-D-GlcNA seemed to be a part of the epitope
IEDB EpitopeN/A
Proposed UtilityThis antisera may help in sertotyping of moraxella strains
Curator IDAA + AS
Date of Curation24-09-2010
References8636949


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