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| PolysacDB ID | 1617 |
| Carbohydrate Name | Lipooligosaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Moraxella catarrhalis serotype A (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | LOS consists of an oligosaccharide and lipid A and is similar to the lipopolysaccharide (LPS) of gramnegative enteric pathogens, but it lacks the O-antigenic side chain of repeating units characteristic of classical LPS. The oligosaccharide part consists of the following residues : α-D-Galp-(1-->4)-β-D-Galp-(1-->4)-α-D-Glcp-(1-->2)-β-D-Glcp-(1-->6)-α-D-Glcp [branched to α-D-GlcpNAc-(1-->2)-β-D-Glcp-(1-->4)] and [branched to β-D-Glcp-(1-->3)] -(1-->5)-Kdo |
| BCSDB Structure | 22728 |
| Proposed functions | Moracella lipooligosaccharide is a potential virulence factor |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Polysera |
| Antibody type and class | N/A |
| Assay System | ELISA and immunoblotting |
| Cross-reactivity | This antisera was specific to serotype A |
| Proposed epitopes | A terminal α-D-GlcNAc-(1-->2)-β-D-Glc seemed to be a part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This antisera may help in sertotyping of moraxella strains |
| Curator ID | AA + AS |
| Date of Curation | 23-09-2010 |
| References | 8636949 |
| PolysacDB ID | 1624 |
| Carbohydrate Name | Lipooligosaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Moraxella catarrhalis serotype A (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | LOS consists of an oligosaccharide and lipid A and is similar to the lipopolysaccharide (LPS) of gramnegative enteric pathogens, but it lacks the O-antigenic side chain of repeating units characteristic of classical LPS. The oligosaccharide part consists of the following residues : α-D-Galp-(1-->4)-β-D-Galp-(1-->4)-α-D-Glcp-(1-->2)-β-D-Glcp-(1-->6)-α-D-Glcp [branched to α-D-GlcpNAc-(1-->2)-β-D-Glcp-(1-->4)] and [branched to β-D-Glcp-(1-->3)] -(1-->5)-Kdo |
| BCSDB Structure | 22728 |
| Proposed functions | Moracella lipooligosaccharide is a potential virulence factor |
| Antigenic Nature used to produce antibodies | Heat inactivated Moraxella catarrhalis serotype A |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab 219A9 |
| Antibody type and class | IgM |
| Assay System | ELISA, bactericidal assays and immunofluorescence assay |
| Cross-reactivity | MAb 219A9 was specific for a common epitope of A, B, and C M. catarrhalis serotypes. It also cross-reacted with whole bacteria and LPS antigens isolated from non-typeable H. influenzae and H. parainfluenzae strains |
| Proposed epitopes | 6-linked branch α-D-Galpara-(1-->4)-β-D-Galpara-(1-->4)-α-D-Glcpara-(1-->2)-β-D-lcpara seemed to be a part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab possessed a strong bactericidal effect against the three serotypes in the presence of complement |
| Curator ID | AA + AS |
| Date of Curation | 25-09-2010 |
| References | 17211546 |
| PolysacDB ID | 1625 |
| Carbohydrate Name | Lipooligosaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Moraxella catarrhalis serotype A (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | LOS consists of an oligosaccharide and lipid A and is similar to the lipopolysaccharide (LPS) of gramnegative enteric pathogens, but it lacks the O-antigenic side chain of repeating units characteristic of classical LPS. The oligosaccharide part consists of the following residues : α-D-Galp-(1-->4)-β-D-Galp-(1-->4)-α-D-Glcp-(1-->2)-β-D-Glcp-(1-->6)-α-D-Glcp [branched to α-D-GlcpNAc-(1-->2)-β-D-Glcp-(1-->4)] and [branched to β-D-Glcp-(1-->3)] -(1-->5)-Kdo |
| BCSDB Structure | 22728 |
| Proposed functions | Moracella lipooligosaccharide is a potential virulence factor |
| Antigenic Nature used to produce antibodies | Heat inactivated Moraxella catarrhalis serotype A |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab 218A8 |
| Antibody type and class | IgG3 |
| Assay System | ELISA, bactericidal assays and immunofluorescence assay |
| Cross-reactivity | Mab 218A8 reacted with two serotypes A and C |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab could be useful for the detection of M. catarrhalis and its LOS antigen in clinical samples |
| Curator ID | AA + AS |
| Date of Curation | 25-09-2010 |
| References | 17211546 |
| PolysacDB ID | 1626 |
| Carbohydrate Name | Lipooligosaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Moraxella catarrhalis serotype A (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | LOS consists of an oligosaccharide and lipid A and is similar to the lipopolysaccharide (LPS) of gramnegative enteric pathogens, but it lacks the O-antigenic side chain of repeating units characteristic of classical LPS. The oligosaccharide part consists of the following residues : α-D-Galp-(1-->4)-β-D-Galp-(1-->4)-α-D-Glcp-(1-->2)-β-D-Glcp-(1-->6)-α-D-Glcp [branched to α-D-GlcpNAc-(1-->2)-β-D-Glcp-(1-->4)] and [branched to β-D-Glcp-(1-->3)] -(1-->5)-Kdo |
| BCSDB Structure | 22728 |
| Proposed functions | Moracella lipooligosaccharide is a potential virulence factor |
| Antigenic Nature used to produce antibodies | Heat inactivated Moraxella catarrhalis serotype A |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab 217H4 |
| Antibody type and class | IgG3 |
| Assay System | ELISA, bactericidal assays and immunofluorescence assay |
| Cross-reactivity | This Mab was specific to serotype A |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab could be useful for the detection of M. catarrhalis and its LOS antigen in clinical samples |
| Curator ID | AA + AS |
| Date of Curation | 25-09-2010 |
| References | 17211546 |
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Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020 |