PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 2

Entry No. - 1   [TOP]
PolysacDB ID1560
Carbohydrate NameUnknown carbohydrate   (Drugpedia)
Carbohydrate ClassGlycolipid
MicrobeLeptospira interrogans serovar copenhageni   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed functionsN/A
Antigenic Nature used to produce antibodiesWhole cells
Carrier NameNil
Conjugation MethodNil
AntibodiesMab F12 C3
Antibody type and classIgG2a
Assay SystemMicroscopic agglutination test, double gel diffusion, Passive protection experiments, immunoblotting
Cross-reactivityThis Mab cross-reacted with serovars icterohaemorrhagiae
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab gave protection against challenge with virulent serovar copenhageni
Curator IDAA + AS
Date of Curation08-09-2010
References2778433


Entry No. - 2   [TOP]
PolysacDB ID1561
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeLeptospira interrogans serovar copenhageni   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed functionsN/A
Antigenic Nature used to produce antibodiesA suspension of serovar copenhageni strain H45 leptospires
Carrier NameNil
Conjugation MethodNil
AntibodiesMab MUM/F 1 - 1 /copenhageni
Antibody type and classIgA
Assay SystemEnzyme immunoassay, immunodiffusion and immunoblotting, Passive protection experiments
Cross-reactivityThis Mab reacted with 1 1 of the 17 serovars of the Icterohaemorrhagiae serogroup, but did not react significantly with representative serovars of the other serogroups of L. interrogans or other species of Leptospira
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab opsonised viable leptospires for phagocytosis and was further shown to protect against lethal infection in susceptible animals
Curator IDAA + AS
Date of Curation08-09-2010
References2430103


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