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PolysacDB ID | 1542 |
Carbohydrate Name | Unknown carbohydrate (Drugpedia) |
Carbohydrate Class | Capsular polysaccharide |
Microbe | Leishmania tropica (LRC-L137) (NCBI Taxonomy) (Drugpedia) |
Basic Structure | N/A |
BCSDB Structure | N/A |
Proposed functions | N/A |
Antigenic Nature used to produce antibodies | L. tropica (LRC-L137) promastigotes |
Carrier Name | Nil |
Conjugation Method | Nil |
Antibodies | Mab L-5-85 |
Antibody type and class | IgG2a |
Assay System | Solid-phase radioimmunoassay, Indirect fluorescent antibody test |
Cross-reactivity | This Mab cross-reacted with 4 strains of L. tropica - L137, L287, L251, L38. It also cross-reacted with L. enriettii L144 strain |
Proposed epitopes | N/A |
IEDB Epitope | N/A |
Proposed Utility | This Mab would allow the study of the origin and the location of the Leishmania spp. antigens on the macrophage membrane as well as the characterization of these antigens in terms of their relationship to host histocompatibility antigens involved in antigen presentation |
Curator ID | AA + AS |
Date of Curation | 03-09-2010 |
References | PMC347485 |
PolysacDB ID | 1543 |
Carbohydrate Name | Unknown carbohydrate (Drugpedia) |
Carbohydrate Class | Capsular polysaccharide |
Microbe | Leishmania tropica (LRC-L137) (NCBI Taxonomy) (Drugpedia) |
Basic Structure | N/A |
BCSDB Structure | N/A |
Proposed functions | N/A |
Antigenic Nature used to produce antibodies | L. tropica (LRC-L137) promastigotes |
Carrier Name | Nil |
Conjugation Method | Nil |
Antibodies | Mab L-5-41 |
Antibody type and class | IgG2b |
Assay System | Solid-phase radioimmunoassay, Indirect fluorescent antibody test |
Cross-reactivity | This Mab cross-reacted with 4 strains of L. tropica - L137, L287, L251, L38. It did not cross-react with any other Leishmania species |
Proposed epitopes | N/A |
IEDB Epitope | N/A |
Proposed Utility | This Mab abolished capacity of the pathogen to multiply within macrophages in vitro and indeed promoted parasite killing |
Curator ID | AA + AS |
Date of Curation | 03-09-2010 |
References | PMC347485 |
Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020 |