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| PolysacDB ID | 1455 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Haemophilus ducreyi (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consist of an oligosaccharide core ketosidically linked via a 3-deoxy-D-manno-octulosonic acid (Kdo) residue to the lipid A region. The oligosaccharide core characteristic of these bacteria has been divided into two regions: (i) an inner core, consisting of three L-glycero-D-manno-heptose (Hep) residues and one phosphorylated Kdo residue, and (ii) an outer core, with one or more heterogeneous oligosaccharide branches containing mainly galactose (Gal) and glucose (Glc) residues |
| BCSDB Structure | N/A |
| Proposed functions | LPS plays an important role in the infection process |
| Antigenic Nature used to produce antibodies | Total membrane preparation of H. ducreyi |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab DP8 |
| Antibody type and class | IgG1 |
| Assay System | Whole-cell enzyme immunoassay (Enzyme Immunoassay) and colony dot immunoblotting |
| Cross-reactivity | This Mab cross-reacted with 50 strains of H. ducreyi but not with any other bacteria tested |
| Proposed epitopes | Phosphate groups seemed to be an important part of the epitope. The epitope consists of Glcβ1-->4Hepα1-->Kdo(P) that is linked via 1-->3 linkage to Hepα1-->2Hep |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help to detect the organism in environmental samples and clinical specimens |
| Curator ID | AA + AS |
| Date of Curation | 23-07-2010 |
| References | PMC173357 |
| PolysacDB ID | 1456 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Haemophilus ducreyi (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consist of an oligosaccharide core ketosidically linked via a 3-deoxy-D-manno-octulosonic acid (Kdo) residue to the lipid A region. The oligosaccharide core characteristic of these bacteria has been divided into two regions: (i) an inner core, consisting of three L-glycero-D-manno-heptose (Hep) residues and one phosphorylated Kdo residue, and (ii) an outer core, with one or more heterogeneous oligosaccharide branches containing mainly galactose (Gal) and glucose (Glc) residues |
| BCSDB Structure | N/A |
| Proposed functions | LPS plays an important role in the infection process |
| Antigenic Nature used to produce antibodies | Total membrane preparation of H. ducreyi |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab DH24 |
| Antibody type and class | IgM |
| Assay System | Whole-cell enzyme immunoassay (Enzyme Immunoassay) and colony dot immunoblotting |
| Cross-reactivity | This Mab bound to 43 of 50 strains of H. ducreyi and to few strains of H. influenzae, Neisseria gonorrhoeae, and Neisseria meningitidis |
| Proposed epitopes | Lacto-N-neotetraose (Galβ1-->4GlcNAcβ1-->3Galβ1-->4Glc) seems to be a part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would help to detect the organism in environmental samples and clinical specimens |
| Curator ID | AA + AS |
| Date of Curation | 23-07-2010 |
| References | PMC173357 |
| PolysacDB ID | 1458 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Haemophilus ducreyi (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consist of an oligosaccharide core ketosidically linked via a 3-deoxy-D-manno-octulosonic acid (Kdo) residue to the lipid A region. The oligosaccharide core characteristic of these bacteria has been divided into two regions: (i) an inner core, consisting of three L-glycero-D-manno-heptose (Hep) residues and one phosphorylated Kdo residue, and (ii) an outer core, with one or more heterogeneous oligosaccharide branches containing mainly galactose (Gal) and glucose (Glc) residues |
| BCSDB Structure | 1605 |
| Proposed functions | LPS plays an important role in the infection process |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab MAHD6 |
| Antibody type and class | IgM |
| Assay System | ELISA and immunoblotting |
| Cross-reactivity | This antibody was specific to H. ducreyi but with none of the other Haemophilus or Bordetella spp. |
| Proposed epitopes | The epitope consisted of (-DD-Hepp-1-->6-β-D-Glcp-) |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would aid in the classification of H. ducreyi for epidemiological purposes |
| Curator ID | AA + AS |
| Date of Curation | 23-07-2010 |
| References | PMC175445 |
| PolysacDB ID | 1459 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Haemophilus ducreyi (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It consist of an oligosaccharide core ketosidically linked via a 3-deoxy-D-manno-octulosonic acid (Kdo) residue to the lipid A region. The oligosaccharide core characteristic of these bacteria has been divided into two regions: (i) an inner core, consisting of three L-glycero-D-manno-heptose (Hep) residues and one phosphorylated Kdo residue, and (ii) an outer core, with one or more heterogeneous oligosaccharide branches containing mainly galactose (Gal) and glucose (Glc) residues |
| BCSDB Structure | 1605 |
| Proposed functions | LPS plays an important role in the infection process |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab MAHD7 |
| Antibody type and class | IgM |
| Assay System | ELISA and immunoblotting |
| Cross-reactivity | It reacts with all H. ducreyi strains |
| Proposed epitopes | MAb MAHD7 recognizes the common conserved inner core region of the LOS |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab would aid in the classification of H. ducreyi for epidemiological purposes |
| Curator ID | AA + AS |
| Date of Curation | 23-07-2010 |
| References | PMC175445 |
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Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020 |