PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 2

Entry No. - 1   [TOP]
PolysacDB ID1453
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeFrancisella tularensis   (NCBI Taxonomy)   (Drugpedia)
Basic StructureThe O-antigen consisted of the following residues : -2)βD-Quip4NFo(1-->4)α-D-GalpNAcA6NH2(1-->4)α-D-GalpNAcA6NH2(1-->3)βDQuipNAc(1-
BCSDB Structure9363
Proposed functionsIt is an important virulence factor
Antigenic Nature used to produce antibodiesHeat-killed F. tularensis
Carrier NameNil
Conjugation MethodNil
AntibodiesMab FT14
Antibody type and classIgM
Assay SystemELISA and immunoblotting
Cross-reactivityThis Mab was unique to F. tularensis
Proposed epitopesO-side chains seems to be an important part of the epitope
IEDB EpitopeN/A
Proposed UtilityThis Mab would help to detect the organism in environmental samples and clinical specimens
Curator IDAA + AS
Date of Curation22-07-2010
ReferencesPMC270126


Entry No. - 2   [TOP]
PolysacDB ID1454
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeFrancisella tularensis   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed functionsIt is an important virulence factor
Antigenic Nature used to produce antibodiesHeat-killed F. tularensis
Carrier NameNil
Conjugation MethodNil
AntibodiesMab FT2F11
Antibody type and classIgM
Assay SystemELISA and immunoblotting
Cross-reactivityFT2F11 cross-reacted with V. cholerae LPS at a low avidity
Proposed epitopesThis Mab reacts with the inner core of the LPS
IEDB EpitopeN/A
Proposed UtilityThis Mab would help to detect the organism in environmental samples and clinical specimens
Curator IDAA + AS
Date of Curation22-07-2010
ReferencesPMC270126


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