| PolysacDB ID | 1180 |
| Carbohydrate Name | Lipoologosaccharide band A of the LPS (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Bordetella pertusis 114 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | N/A
|
| BCSDB Structure | N/A |
| Proposed functions | The LOS of B. pertussis exhibits biological activities similar to those of endotoxins from other gram-negative bacteria, including pyrogenicity, toxicity, induction of the Shwartzman reaction, induction of tumor necrosis factor production, and adjuvant properties |
| Antigenic Nature used to produce antibodies | Partially purified preparations of fimbriae from B. pertussis 114 |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab G1OF8C3 |
| Antibody type and class | IgG3 |
| Assay System | Immunoblotting |
| Cross-reactivity | Four strains of Bordetella bronchiseptica and three strains of Bordetella parapertussis were not agglutinated, nor were other gram-negative bacteria, such as Escherichia coli, N.meningitidis, Neisseria gonorrhoeae, Salmonella typhimurium, and Haemophilus influenzae |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab specifically agglutinated the bacteria. It could be useful in establishing a better-defined serotyping system for B. pertussis in which LOS A might be considered a typing antigen. This Mab can also be useful for the estimation of contaminating levels of endotoxin in vaccine preparations and for further studies on the structure of B. pertussis LOS. |
| Curator ID | AA + AS |
| Date of Curation | 27-02-2010
|
| References | PMC259348 |