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| PolysacDB ID | 1127 |
| Carbohydrate Name | CA antigen (Drugpedia) |
| Carbohydrate Class | Glycoprotein |
| Microbe | Aspergillus fumigatus 2085 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Galactomannans are composed of an α-1,6-linked mannan backbone substituted with mannopyranose oligosaccharides and immunodominant terminal galactofuranose present either singly or linked to oligogalactosides |
| BCSDB Structure | N/A |
| Proposed functions | The wide distribution and similar chemical structure of the galactomannans have been responsible for serologic cross-reactions |
| Antigenic Nature used to produce antibodies | Cell walls of A. fumigatus 2085 |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab SC1 |
| Antibody type and class | IgM |
| Assay System | Enzyme Immunoassay, Precipitin reactions, Immunoblotting, Immunofluorescence assays |
| Cross-reactivity | MAb SC1 was reactive with other Aspergillus species, Fusarium sp., and dermatophytes |
| Proposed epitopes | Galactomannan residues seemed to be the part of immunodominant region |
| IEDB Epitope | N/A |
| Proposed Utility | These MAbs will be useful as immunoprobes for studying epitopes responsible for the shared antigenicity of fungal mannans and galactomannans and for examining their expression during hyphal and conidial morphogenesis |
| Curator ID | AA + AS |
| Date of Curation | 07-02-2010 |
| References | PMC258783 |
| PolysacDB ID | 1128 |
| Carbohydrate Name | CA antigen (Drugpedia) |
| Carbohydrate Class | Glycoprotein |
| Microbe | Aspergillus fumigatus 2085 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Galactomannans are composed of an α-1,6-linked mannan backbone substituted with mannopyranose oligosaccharides and immunodominant terminal galactofuranose present either singly or linked to oligogalactosides |
| BCSDB Structure | N/A |
| Proposed functions | The wide distribution and similar chemical structure of the galactomannans have been responsible for serologic cross-reactions |
| Antigenic Nature used to produce antibodies | Cell walls of A. fumigatus 2086 |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab SC40 |
| Antibody type and class | IgG |
| Assay System | Enzyme Immunoassay, Precipitin reactions, Immunoblotting, Immunofluorescence assays |
| Cross-reactivity | MAb SC40 was reactive with other Aspergillus species, Fusarium sp., and dermatophytes.also cross-reacted to mannans of Candida albicans serotype A and B, C.tropicalis |
| Proposed epitopes | Galactomannan residues seemed to be the part of immunodominant region |
| IEDB Epitope | N/A |
| Proposed Utility | These MAbs will be useful as immunoprobes for studying epitopes responsible for the shared antigenicity of fungal mannans and galactomannans and for examining their expression during hyphal and conidial morphogenesis |
| Curator ID | AA + AS |
| Date of Curation | 08-02-2010 |
| References | PMC258783 |
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Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020 |