PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613

Total Entries - 5
Entry No. - 1 [TOP]

PolysacDB ID	2647
Carbohydrate Name	Serotype b-specific polysaccharide antigen (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe	Actinobacillus actinomycetemcomitans Y4 (NCBI Taxonomy) (Drugpedia)
Basic Structure	Serotype b-specific antigen of A. actinomycetemcomitans is a capsular polysaccharide-like antigen consisting of a disaccharide repeating unit, 33)-a-D-fucopyranosyl-(132)-b-L-rhamnopyranosyl-(1-
BCSDB Structure	N/A
Proposed functions	SPA of A. actinomycetemcomitans plays an important role in the resistance to phagocytosis and killing by human PMNs.
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	N/A
Conjugation Method	N/A
Antibodies	IgG1
Antibody type and class	Mab S2
Assay System	Chemiluminescence (CL) assay, immunoblotting and phagocytic killing assay
Cross-reactivity	N/A
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab enhanced CL responses of human PMNs to the organism and killing of the organism by human PMNs
Curator ID	AA + AS
Date of Curation	21-01-2012
References	PMC173659

Entry No. - 2 [TOP]

PolysacDB ID	2648
Carbohydrate Name	Serotype b-specific polysaccharide antigen (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe	Actinobacillus actinomycetemcomitans Y4 (NCBI Taxonomy) (Drugpedia)
Basic Structure	Serotype b-specific antigen of A. actinomycetemcomitans is a capsular polysaccharide-like antigen consisting of a disaccharide repeating unit, 33)-a-D-fucopyranosyl-(132)-b-L-rhamnopyranosyl-(1-
BCSDB Structure	N/A
Proposed functions	SPA of A. actinomycetemcomitans plays an important role in the resistance to phagocytosis and killing by human PMNs.
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	N/A
Conjugation Method	N/A
Antibodies	IgG2a
Antibody type and class	Mab S4
Assay System	Chemiluminescence (CL) assay, immunoblotting and phagocytic killing assay
Cross-reactivity	N/A
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab enhanced CL responses of human PMNs to the organism and killing of the organism by human PMNs
Curator ID	AA + AS
Date of Curation	21-01-2012
References	PMC173659

Entry No. - 3 [TOP]

PolysacDB ID	2649
Carbohydrate Name	Serotype b-specific polysaccharide antigen (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe	Actinobacillus actinomycetemcomitans Y4 (NCBI Taxonomy) (Drugpedia)
Basic Structure	Serotype b-specific antigen of A. actinomycetemcomitans is a capsular polysaccharide-like antigen consisting of a disaccharide repeating unit, 33)-a-D-fucopyranosyl-(132)-b-L-rhamnopyranosyl-(1-
BCSDB Structure	N/A
Proposed functions	SPA of A. actinomycetemcomitans plays an important role in the resistance to phagocytosis and killing by human PMNs.
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	N/A
Conjugation Method	N/A
Antibodies	IgG3
Antibody type and class	Mab S5
Assay System	Chemiluminescence (CL) assay, immunoblotting and phagocytic killing assay
Cross-reactivity	N/A
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab enhanced CL responses of human PMNs to the organism and killing of the organism by human PMNs
Curator ID	AA + AS
Date of Curation	25-01-2012
References	PMC173659

Entry No. - 4 [TOP]

PolysacDB ID	2650
Carbohydrate Name	Serotype b-specific polysaccharide antigen (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe	Actinobacillus actinomycetemcomitans Y4 (NCBI Taxonomy) (Drugpedia)
Basic Structure	Serotype b-specific antigen of A. actinomycetemcomitans is a capsular polysaccharide-like antigen consisting of a disaccharide repeating unit, 33)-a-D-fucopyranosyl-(132)-b-L-rhamnopyranosyl-(1-
BCSDB Structure	N/A
Proposed functions	SPA of A. actinomycetemcomitans plays an important role in the resistance to phagocytosis and killing by human PMNs.
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	N/A
Conjugation Method	N/A
Antibodies	IgG3
Antibody type and class	Mab S8
Assay System	Chemiluminescence (CL) assay, immunoblotting and phagocytic killing assay
Cross-reactivity	N/A
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab enhanced CL responses of human PMNs to the organism and killing of the organism by human PMNs
Curator ID	AA + AS
Date of Curation	25-01-2012
References	PMC173659

Entry No. - 5 [TOP]

PolysacDB ID	2651
Carbohydrate Name	Serotype b-specific polysaccharide antigen (Drugpedia)
Carbohydrate Class	Lipopolysaccharide
Microbe	Actinobacillus actinomycetemcomitans Y4 (NCBI Taxonomy) (Drugpedia)
Basic Structure	Serotype b-specific antigen of A. actinomycetemcomitans is a capsular polysaccharide-like antigen consisting of a disaccharide repeating unit, 33)-a-D-fucopyranosyl-(132)-b-L-rhamnopyranosyl-(1-
BCSDB Structure	N/A
Proposed functions	SPA of A. actinomycetemcomitans plays an important role in the resistance to phagocytosis and killing by human PMNs.
Antigenic Nature used to produce antibodies	Whole cells
Carrier Name	N/A
Conjugation Method	N/A
Antibodies	IgM
Antibody type and class	Mab S9
Assay System	Chemiluminescence (CL) assay, immunoblotting and phagocytic killing assay
Cross-reactivity	N/A
Proposed epitopes	N/A
IEDB Epitope	N/A
Proposed Utility	This Mab did not enhance CL responses of human PMNs to the organism and did not promote killing of the organism by human PMNs
Curator ID	AA + AS
Date of Curation	25-01-2012
References	PMC173659

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