| PolysacDB ID | 2023 |
| Carbohydrate Name | Core oligosaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Pseudomonas aeruginosa (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | The LPS consists of three regions, namely O-polysaccharide, core oligosaccharide and lipid A. The core region of LPS is divided into the outer core and inner core. The inner core region consists of 2-keto-3-deoxyoctonic acid (KDO), heptose, phosphate, and probably ethanolamine. The outer core region commonly contains D-glucose, L-rhamnose, D-galactosamine, and L-alanine. The O-antigens consist of a trisaccharide repeating unit which consists of two uronic acid derivatives and one N-acetyl fucosamine residue
|
| BCSDB Structure | N/A |
| Proposed functions | N/A |
| Antigenic Nature used to produce antibodies | Formalin-killed P. aeruginosa cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab OM-lD6 |
| Antibody type and class | IgM |
| Assay System | ELISA, immunoblotting and flow cytometry |
| Cross-reactivity | This Mab bound to P. aeruginosa strains. OM-1D6 reacted with all strains of serotype G so far tested, and a few strains of serotype M |
| Proposed epitopes | This Mab reacted with the core region of the LPS. L-rhamnose in the LPS core of serotype G was an immunodominant sugar recognized by OM-1D6 |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab showed a high level of protective activity against P.aeruginosa in an experimental infection model using normal mice |
| Curator ID | AA + AS |
| Date of Curation | 20-12-2010
|
| References | 1564440 |