PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID2534
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeVibrio cholerae 47-4041 serotype Ogawa   (NCBI Taxonomy)   (Drugpedia)
Basic StructureIt is a linear unbranched homopolymer of 1,6-linked-D-galactopyranosyl residues.
BCSDB StructureN/A
Proposed functionsV. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera
Antigenic Nature used to produce antibodiesKilled cells
Carrier NameNil
Conjugation MethodNil
AntibodiesMab OF2
Antibody type and classIgG3
Assay SystemSlide or microdilution agglutination methods, along with enzyme-linked immunosorbent assays and immunoblotting analysis
Cross-reactivityThis Mab reacted only with Ogawa-type V. cholerae
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab agglutinated both live and heat killed Ogawa cells
Curator IDAA + AS
Date of Curation19-06-2011
References2448333


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