PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID2040
Carbohydrate NameO-polysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobePseudomonas aeruginosa Serotype O2   (NCBI Taxonomy)   (Drugpedia)
Basic StructureThe LPS consists of three regions, namely O-polysaccharide, core oligosaccharide and lipid A. The O-antigens consist of a trisaccharide repeating unit which consists of two uronic acid derivatives and one N-acetyl fucosamine residue
BCSDB Structure21549
Proposed functionsN/A
Antigenic Nature used to produce antibodiesFormalin killed whole cells
Carrier NameNil
Conjugation MethodNil
AntibodiesMab MF71-3
Antibody type and classIgM
Assay SystemELISA, immunoblotting, ouchterlony immunodiffusion
Cross-reactivityThis Mab was specific to serotype O2
Proposed epitopesThe epitope consisted of the L-guluronic acid-(α1-->3)-D-FucNAc(β1-->4) portion of the O2-antigen
IEDB EpitopeN/A
Proposed UtilityThis Mab helps us shed some light on the nature of O-specific and common epitopes in the LPS of P. aeruginosa
Curator IDAA + AS
Date of Curation25-12-2010
ReferencesPMC205836


Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020