PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID2229
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeSalmonella minnesota Re chemotype 595   (NCBI Taxonomy)   (Drugpedia)
Basic StructureLPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The core oligosaccharide part consists of the following residues : α-Kdop-(2-8)-α-Kdop-(2-->4)-Kdo
BCSDB Structure147530
Proposed functionsLPS plays an important virulence role based on its antiphagocytic and endotoxic properties
Antigenic Nature used to produce antibodiesHeat killed bacteria
Carrier NameNil
Conjugation MethodNil
AntibodiesMab MASM3
Antibody type and classIgG2b
Assay SystemEnzyme immunoassay, ELISA
Cross-reactivityThis Mab cross-reacted with Salmoneela typhimurium SL1102 Re chemotype LPS
Proposed epitopes3-deoxy-D-mannooctulosonic acid [KDO] residues at the terminal non-reducing ends seemed to be the part of the epitope
IEDB EpitopeN/A
Proposed UtilityThis Mab would help elucidate the Kdo LPS domain structure
Curator IDAA + AS
Date of Curation14-03-2011
References2033255


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