PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID1458
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeHaemophilus ducreyi   (NCBI Taxonomy)   (Drugpedia)
Basic StructureIt consist of an oligosaccharide core ketosidically linked via a 3-deoxy-D-manno-octulosonic acid (Kdo) residue to the lipid A region. The oligosaccharide core characteristic of these bacteria has been divided into two regions: (i) an inner core, consisting of three L-glycero-D-manno-heptose (Hep) residues and one phosphorylated Kdo residue, and (ii) an outer core, with one or more heterogeneous oligosaccharide branches containing mainly galactose (Gal) and glucose (Glc) residues
BCSDB Structure1605
Proposed functionsLPS plays an important role in the infection process
Antigenic Nature used to produce antibodiesWhole cells
Carrier NameNil
Conjugation MethodNil
AntibodiesMab MAHD6
Antibody type and classIgM
Assay SystemELISA and immunoblotting
Cross-reactivityThis antibody was specific to H. ducreyi but with none of the other Haemophilus or Bordetella spp.
Proposed epitopesThe epitope consisted of (-DD-Hepp-1-->6-β-D-Glcp-)
IEDB EpitopeN/A
Proposed UtilityThis Mab would aid in the classification of H. ducreyi for epidemiological purposes
Curator IDAA + AS
Date of Curation23-07-2010
ReferencesPMC175445


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