PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID2394
Carbohydrate Name125 Kda antigen   (Drugpedia)
Carbohydrate ClassGlycoprotein
MicrobeStreptococcus mutans OMZ175 (serotype f)   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed functionsN/A
Antigenic Nature used to produce antibodiesCell wall extracted antigens
Carrier NameNil
Conjugation MethodNil
AntibodiesMab LOSM2
Antibody type and classIgM
Assay SystemWestern blotting and immunoprecipitation techniques, enzyme-linked immunosorbent assay (ELISA), and competitive ELISA
Cross-reactivityMonoclonal antibody LOSM1 showed a quite identical reactivity with WEA from S. mutans serotypes f and b, reduced activity against WEA from serotypes c, e, and a, and weak binding to serotypes d and g
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityUsing this monoclonal antibody, it has been demonstrated that cross-reactivity and conservation of the specific epitopes among the various S. mutans serotypes. These Mab should be useful in studying the streptococcal surface moities
Curator IDAA + AS
Date of Curation29-04-2011
ReferencesPMC262021


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