PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID1543
Carbohydrate NameUnknown carbohydrate   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
MicrobeLeishmania tropica (LRC-L137)   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed functionsN/A
Antigenic Nature used to produce antibodiesL. tropica (LRC-L137) promastigotes
Carrier NameNil
Conjugation MethodNil
AntibodiesMab L-5-41
Antibody type and classIgG2b
Assay SystemSolid-phase radioimmunoassay, Indirect fluorescent antibody test
Cross-reactivityThis Mab cross-reacted with 4 strains of L. tropica - L137, L287, L251, L38. It did not cross-react with any other Leishmania species
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab abolished capacity of the pathogen to multiply within macrophages in vitro and indeed promoted parasite killing
Curator IDAA + AS
Date of Curation03-09-2010
ReferencesPMC347485


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