| PolysacDB ID | 2531 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Vibrio cholerae 01 serogroup Inaba strain X19203 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a linear unbranched homopolymer of 1,6-linked-D-galactopyranosyl residues. |
| BCSDB Structure | N/A |
| Proposed functions | V. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera |
| Antigenic Nature used to produce antibodies | Killed cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab IH 18 |
| Antibody type and class | IgG3 |
| Assay System | Slide agglutination, microdilution agglutination, and passive hemagglutination tests |
| Cross-reactivity | This Mab reacted only to Inaba-type cells; no agglutination was observed for Ogawa-type cells in either the slide agglutination or the microdilution agglutination tests. This Mab showed cross-reactivity to Brucella abortus |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab showed strong agglutination with both live cells and heat-killed cells. This Mab will be a very useful tool for resolution of the antigenic structure of V. cholerae 01, especially the Inaba-specific determinant, as well as crossreactive structure to B. abortus. Moreover, highly Inabaspecific antibodies will be able to be used in the identification of Inaba serotypes instead of polyclonal Inaba-specific antisera |
| Curator ID | AA + AS |
| Date of Curation | 18-06-2011
|
| References | PMC266894 |