PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID1360
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeChlamydia trachomatis serotype G   (NCBI Taxonomy)   (Drugpedia)
Basic StructureThe LPS is composed of the pentasaccharide bisphosphate αKdo-(2-8)-αKdo-(2-->4)-αKdo-(2-6)-βGlcN-4P-(1-->6) αGlcN-1P (Kdo is 3-deoxy-α-d-manno-oct-2-ulosonic acid)
BCSDB StructureN/A
Proposed functionsLPS is most unusual constituents of outer membrane. It plays important role in host defence avoidance. LPS contributes to the negative charge of the bacterial surface. Lipid A is often toxic and act as endotoxin
Antigenic Nature used to produce antibodiesElementary bodies of Chlamydia trachomatis serotype G
Carrier NameNil
Conjugation MethodNil
AntibodiesMab G2-B3
Antibody type and classIgG2b
Assay SystemIFT assay, ELISA
Cross-reactivityThis antibody cross-reacted with Salmonella Minnesota LPS and Chlamydia psittaci
Proposed epitopesThe epitope cosisted of a trisaccharide of a-3-deoxy-D-manno-2-octulosonic acid (KDO)
IEDB Epitope76828
Proposed UtilityThis Mab can be used in the epitope characterization of Chlamydial LPS
Curator IDAA + AS
Date of Curation27-06-2010
ReferencesPMC258430


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