PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID1365
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeChlamydia pneumoniae TW-183   (NCBI Taxonomy)   (Drugpedia)
Basic StructureIt has the core lipid A moiety and 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) core but lacks the distal O-polysaccharide region
BCSDB StructureN/A
Proposed functionsN/A
Antigenic Nature used to produce antibodiesWhole cells
Carrier NameNil
Conjugation MethodNil
AntibodiesMab CP-33
Antibody type and classIgG2b
Assay SystemN/A
Cross-reactivityThis Mab recognized the LPSs of C. pneumoniae, Chlamydia trachomatis, and Chlamydia psittaci but did not react with 15 genera of gram-negative and gram-positive bacteria and Candida albicans
Proposed epitopesThis Mab recognizes a trisaccharide epitope αKdo(2-->8) αKdo(2-->4)αKdo
IEDB EpitopeN/A
Proposed UtilityThis Mab neutralizes both in vitro and in vivo the infectivity of C. pneumoniae
Curator IDAA + AS
Date of Curation29-06-2010
ReferencesPMC108433


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