PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID1159
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeBacteroides fragilis   (NCBI Taxonomy)   (Drugpedia)
Basic StructureThe polysaccharide part of the LPS mainly consists of two fractions : PSI : β-D-Galp(1-->6)β-D-Galp(1-->6)β-D-Galp(1-->6)Residue1-α-D-Glcp [branched to Residue no. 2](1-->2)α-L-Rhap and PSII : β-D-Galp(1-->4)α-D-Glcp [Branched to β-D-Galp(1-->6)](1-->2)α-L-Rhap
BCSDB Structure122912
Proposed functionsLPS polysaccharide of B. gingivalis may represent a virulence factor
Antigenic Nature used to produce antibodiesOuter membrane extract of B. fragilis 23475
Carrier NameNil
Conjugation MethodNil
AntibodiesMab BF3
Antibody type and classN/A
Assay SystemEnzyme Immunoassay, Inhibition assay, Immunoblotting
Cross-reactivityThis antibody cross-reacted with 66 strains of B. fragilis, 4 strains of B.thetaiotaomicron, 2 strains of B. ovatus
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityUsing this Mab LPS can be easily detected in bacterial antigen preparations and clinical samples.
Curator IDAA + AS
Date of Curation22-02-2010
ReferencesPMC271363


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