PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID1376
Carbohydrate NameCapsular polysaccharide 500 antigen   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
MicrobeCryptosporidium parvum   (NCBI Taxonomy)   (Drugpedia)
Basic StructureCPS-500 is a chloroform-extractable glycolipid
BCSDB StructureN/A
Proposed functionsCPS-500 is a candidate target antigen for active or passive immunization against cryptosporidiosis
Antigenic Nature used to produce antibodiesWhole cells
Carrier NameNil
Conjugation MethodNil
AntibodiesMab 18.44
Antibody type and classIgG3
Assay SystemELISA, immunoblotting
Cross-reactivityN/A
Proposed epitopesThe neutralization-sensitive epitope recognized by MAb 18.44 is dependent on terminal β-D-mannopyranosyl residues
IEDB EpitopeN/A
Proposed UtilityMAb 18.44 neutralizes the infectivity of both sporozoites and merozoites and to significantly reduce C. parvum infection in oocyst-challenged mice when coadministered with other neutralizing Mab
Curator IDAA + AS
Date of Curation02-07-2010
References2193057


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