PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 2

Entry No. - 1   [TOP]
PolysacDB ID1060
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeEscherichia coli O157:H7   (NCBI Taxonomy)   (Drugpedia)
Basic Structure-2)α-D-Rhap4NAc(1-->3)α-L-Fucp(1-->4)β-D-Glcp(1-->3)α-D-GalpNAc(1-
BCSDB Structure3776
Proposed functionsN/A
Antigenic Nature used to produce antibodiesWhole cells
Carrier NameNil
Conjugation MethodNil
AntibodiesMab 12D6
Antibody type and classIgG3
Assay SystemELISA, immunoblotting, Fluorescent-antibody microscopy
Cross-reactivityThis antibody cross-reacted with group N Salmonella strains [(S. landau, S. soerenga, (S. urbana and S. godesberg]
Proposed epitopesO-antigen was proposed to be the epitope
IEDB EpitopeN/A
Proposed UtilityThis Mab provide a valuable tool for the rapid detection of E. coli O157
Curator IDAA + AS
Date of Curation18-01-2010
ReferencesPMC229650


Entry No. - 2   [TOP]
PolysacDB ID1318
Carbohydrate NamePhosphomannan protein complex   (Drugpedia)
Carbohydrate ClassGlycoprotein
MicrobeCandida albicans NIH B-792   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed functionsN/A
Antigenic Nature used to produce antibodiesHeat-killed yeast-form cells of Candida albicans NIH B-792 strain
Carrier NameNil
Conjugation MethodNil
AntibodiesMab 12D6
Antibody type and classIgM
Assay SystemN/A
Cross-reactivityThis antibody cross-reacted with NIH A-207 (serotype A) and J-1012 [serotype A] and C. tropicalis IFO 0630
Proposed epitopesThe epitope was proposed to contain β-1,2-linked oligomannosyl residues
IEDB EpitopeN/A
Proposed UtilityAntibodies to β- 1,2-linked oligomannosyl residues can be used as the serodiagnostic agent for detecting the C. albicans antigen(s) in sera and tissues of mammals with candidiasis.
Curator IDAA + AS
Date of Curation09-06-2010
References3280163


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