PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID1806
Carbohydrate NameCapsular polysaccharide   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
MicrobeNeisseria meningitidis Serogroup B   (NCBI Taxonomy)   (Drugpedia)
Basic StructureIt consists of a homopolymer of α(2-->8)-linked sialic acid residues
BCSDB Structure7487
Proposed functionsIt is an important virulence factor
Antigenic Nature used to produce antibodiesWhole cells
Carrier NameNil
Conjugation MethodNil
AntibodiesMab 101C11
Antibody type and classIgG2a
Assay SystemELISA and bactericidal assays
Cross-reactivityThis Mab was specifc to Neisseria meningitidis group B and did not cross-react with group A and group C N. meningitidis capsular polysaccharides. This Mab also recognized N-propionylated capsular polysaccharide of group B meningitidis
Proposed epitopesα[2-->8] linked N-acetyl neuraminic acid residues seemed to be the part of the epitope
IEDB EpitopeN/A
Proposed UtilityThis Mab had potent bactericidal activity
Curator IDAA + AS
Date of Curation05-11-2010
References1284118


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