Cyclic peptides are a unique class of compounds characterized by their circular structure, which enhances their stability and resistance to enzymatic degradation compared to linear peptides. This structural feature not only contributes to their increased half-life in biological systems but also allows for a more rigid conformation, which can improve binding affinity to target proteins.

In this context, the development of a web server dedicated to predicting the permeability characteristics of cyclic peptides represents a significant advancement. This platform serves as a publicly accessible resource for researchers, enabling them to assess how these peptides can traverse biological membranes: a key determinant of their pharmacokinetic properties.