| DB ID | MyCo_7279 |
| Title | Smoking-aggravated oral candidiasis: Nrf2 pathway dampens NLRP3 inflammasome |
| Year | 2021 |
| PMID | 34486221 |
| Fungal Diseases involved | Candidiasis |
| Associated Medical Condition | Smoking- |
| Genus | Candida |
| Species | spp. |
| Organism | Candida spp. |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | None |
| Sample source | None |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | NLRP3 |
| Biomarker Full Name | NOD- like receptor family pyrin domain containing 3 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | France |
| Cohort | None |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Cigarette smoke (CS) contains a complex mixture of oxidants and numerous reactive oxygen species (ROS) predisposing humans to several mild-¬ to-¬ severe oral health problems, including oropharyn- geal candidiasis (OPC) and oral leukoplakia (OLK). OPC, commonly referred to as ‘thrush’, corresponds to infections of various oral mu- cosal sites and is characterized by Candida yeasts overgrowth and invasion of superficial tissues while OLK encompasses white patches or plaques potentially malignant that develops in the oral cavity. Oxidative stress and imbalance of the cellular redox state induced by smoking can change the oral microbiome and damage the struc- ture and function of the oral epithelial barrier, the first-¬ line defence against fungal infections. Smoking may also promote Candida albi- cans pathogenicity by enhancing fungal adhesion, growth and bio- film formation. |
| Technique | None |
| Analysis Method | None |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | None |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
