MycoBiomDB – Record Details (MyCo_7192)

Biomarker Record Details

Database ID: MyCo_7192
DB IDMyCo_7192
TitleRegulatory T cells dampen pulmonary inflammation and lung injury in an animal model of pneumocystis pneumonia
Year2006
PMID17056551
Fungal Diseases involvedPneumocystis pneumonia
DiseasePneumocystis
Associated Medical ConditionNone
GenusPneumocystis
Speciescarinii
OrganismPneumocystis carinii
Ethical StatementAll experiments were approved by the Children’s Hospital of Pittsburgh Animal Research and Care Committee.
Site of InfectionUnspecified
Opportunistic invasiveNone
Sample typeBody fluid
Sample sourceBronchoalveolar lavage fluid (BALF)
Host GroupAnimal
Host Common nameMice
Host Scientific nameMus musculus
Biomarker NameCD4+CD25+FoxP3+
Biomarker Full NameCD4+CD25+FoxP3+
Biomarker TypeDiagnostic
BiomoleculeProtein
Geographical LocationUSA
CohortSix- to 8-wk-old, male C57BL/6 mice were obtained from National Cancer Institute (Frederick, MD). SCID mice were obtained from The Jackson Laboratory. Animals were housed in a pathogen-free environment and given food and water ad libitum.
Cohort No.None
Age GroupNone
P ValueNone
SensitivityNone
SpecificityNone
Positive Predictive ValueNone
Fold ChangeNone
PathwayNone
Disease Introduction MechanismNone
Sub TechniqueMultiplex immunoassays
TechniqueImmunoassay
Analysis MethodBio-Plex multiplex suspension cytokine array ELISA Kit (Bio-Rad Laboratories)
ELISA kitsBio-Plex multiplex suspension cytokine array ELISA Kit (Bio-Rad Laboratories)
Assay DataNone
Validation Techniques usedNone
Up Regulation Down RegulationNone
Sequence DataNone