| DB ID | MyCo_7174 |
| Title | The polysaccharide from Inonotus obliquus protects mice from Toxoplasma gondii-induced liver injury |
| Year | 2019 |
| PMID | 30445083 |
| Fungal Diseases involved | Toxoplasma gondii infection |
| Associated Medical Condition | None |
| Genus | Toxoplasma |
| Species | gondii |
| Organism | Toxoplasma gondii |
| Ethical Statement | All animal experimental procedures were performed in accordance with the guidelines of the Ethical Committee for the Ex-perimental Use of Animals at Yanbian University (Yanji, China). |
| Site of Infection | Liver |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | Nrf2 |
| Biomarker Full Name | Nuclear factor erythroid 2-related factor 2 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | China |
| Cohort | Male BALB/c mice (weight 18–22 g) were purchased from Changchun Yisi Experimental Animal Co. Ltd., China (certificate No. SCXK (Ji) 2011-0004). The mice were domesticated in a controlled temperature (25 ± 1 °C) and humidity (50 ± 5%) and had free access to food and water. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Toxoplasma gondii (T. gondii) is an obligate intracellular protozoan that causes toxoplasmosis in humans and many warm-blooded animals. Approximately 30%–50% of the population is infected with T. gondii worldwide. Toxoplasmosis is considered a leading cause of death in immunocompromised or congenitally infected patients. Acute infec- tion with T. gondii in pregnant women often causes severe birth defects such as intracranial calcification, chorioretinitis, hydrocephaly and mental retardation. |
| Technique | Analytic |
| Analysis Method | Western Blotting |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | ELISA, Western Blotting |
| Up Regulation Down Regulation | Up regulated |
| Sequence Data | None |
| External Link | None |
