| DB ID | MyCo_6954 |
| Title | Biomarker-based classification of bacterial and fungal whole-blood infections in a genome-wide expression study |
| Year | 2015 |
| PMID | 25814982 |
| Fungal Diseases involved | Fungal infection |
| Associated Medical Condition | Sepsis |
| Genus | Candida |
| Species | albicans |
| Organism | Candida albicans |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | CRY2 |
| Biomarker Full Name | CRY2 |
| Biomarker Type | Diagnostic |
| Biomolecule | Gene |
| Geographical Location | Germany |
| Cohort | A human whole-blood model was used as described previously (Hünniger et al., 2014). Briefly, HBSS (for mock-infected con- trol) or the human pathogenic fungi Candida albicans SC5314 and Aspergillus fumigatus ATCC46645 (each 1 × 106/ml), the Gram-positive bacterium Staphylococcus aureus ATCC25923 (1 × 106/ml) and the Gram-negative bacterium Escherichia coli ATCC25922 (4 × 103/ml) were added to anti- coagulated blood of healthy human donors (male, ≤40 years of age) and incubated at 37◦C with gentle rotation for 4 or 8 h. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | >93% |
| Specificity | >97% |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | 10 fold |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | Bioinformatics analysis |
| Analysis Method | Transcriptomics Approach |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Transcriptional footprint |
| Up Regulation Down Regulation | Up regulated |
| Sequence Data | None |
| External Link | None |
