| DB ID | MyCo_6390 |
| Title | Proteomic analysis of serum samples of paracoccidioidomycosis patients with severe pulmonary sequel |
| Year | 2021 |
| PMID | 34424905 |
| Fungal Diseases involved | Paracoccidioidomycosis |
| Associated Medical Condition | None |
| Genus | Paracoccidioides |
| Species | spp. |
| Organism | Paracoccidioides spp. |
| Ethical Statement | All study participants gave their written informed consent for inclusion before they partici-pated in the study. This study was conducted in accordance with the Brazilian Norms and Guidelines Research Regulators Involving Human Beings–(Res. CNS 196/96, II.4), Interna- tional Guidelines for Biomedical Research involving Beings Human Rights–(CIOMS) and the principles of the Declaration of Helsinki. Ethical approval was obtained from the Ethical Com- mittee of Botucatu Medical School, São Paulo State University, Brazil (CAAE: 65525317.9.3001.5398) on May 4, 2017. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | Pleckstrin homology domain-containing family G member 5 |
| Biomarker Full Name | Pleckstrin homology domain-containing family G member 5 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Brazil |
| Cohort | This non-concurrent cohort study included 29 patients with pulmonary PCM that were fol-lowed before and after treatment. |
| Cohort No. | 29 |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Paracoccidioidomycosis (PCM) is a granulomatous systemic mycosis caused by thermo- dimorphic fungi of the genus Paracoccidioides. It is an endemic disease in Latin America and the primary cause of mortality among all endemic systemic mycoses in Brazil. Clinical manifestations range from benign and localized to severe and disseminated. The two main clinical presentations are the acute/subacute form (AF) and the chronic form (CF). CF PCM is the most common form of PCM; this form is usually observed in adult males, with clinical manifestations predominantly in the lungs and upper aerodigestive tract. Even after appro- priate antifungal treatment, most patients with CF present pulmonary sequelae (PS), including pulmonary fibrosis and emphysema. Patients with PS show incapacitating respiratory disorders that prevent them from performing previous occupational activities [6], and in some cases, this condition can trigger psychological problems and intensify the consumption of alco-hol. Despite representing a public health problem, PCM is a neglected disease. |
| Technique | Bioinformatics analysis |
| Analysis Method | Proteomics Approach |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Proteomics Approach |
| Up Regulation Down Regulation | Differentially expressed |
| Sequence Data | UniProt ID: O94827 |
| External Link | None |
