| DB ID | MyCo_6089 |
| Title | Translational proteomic study to address host protein changes during aspergillosis |
| Year | 2018 |
| PMID | 30040865 |
| Fungal Diseases involved | Aspergillosis |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | All the blood specimens from penguins utilized in this work were samples banked after rou- tine veterinary assessments. Investigations in penguins were approved by the African Penguin Species Survival Plan (SSP) of the Association of Zoos & Aquariums (AZA) program and by the staff veterinarians in each of the submitting facilities. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Animal |
| Host Common name | Penguin |
| Host Scientific name | Spheniscidae |
| Biomarker Name | Eukaryotic elongation factor 2 kinase |
| Biomarker Full Name | Eukaryotic elongation factor 2 kinase |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | Blood samples and lung parenchyma specimens were obtained from 6–8 week-old male neutropenic rats (Rattusnorvegicus, N1 = 46). |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | ≥ 4.0 fold |
| Pathway | None |
| Disease Introduction Mechanism | Aspergillosis is a fungal airborne infection due to saprophytic ubiquitous molds that belong to Aspergillus genus. It is responsible for several distinct respiratory diseases in both animals and humans. For example, aspergillosis is subacute or chronic in penguins under human care in zoos, and its incidence was estimated to 20.2% in a rehabilitation center in Brazil. In such birds, it implies adaptive immunity and develops progressively at the inner surface of air sacs. In humans, the invasive form is rather encountered during severe neutropenia and is more acute; its incidence raised to 5% after intensive chemotherapy or allogenic hematopoi- etic stem-cell transplantation. Invasive aspergillosis causes high morbidity, and mortality rates have been estimated as 30–70%, depending on the underlying medical conditions, the site of infection and the degree of dissemination. The Aspergillusspecies of the Fumigati section are those which have been primarily isolated from most of the human and animal clini- cal specimens. Species belonging to Flavi, Nigrior Terrei sections have been less frequently cul- tured. |
| Technique | Bioinformatics analysis |
| Analysis Method | Proteomics Analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Proteomics Analysis |
| Up Regulation Down Regulation | Increase |
| Sequence Data | Access. number (UniProt) A0A087R6I1 |
| External Link | None |
