| DB ID | MyCo_5888 |
| Title | Galectin-3 Is a Crucial Immunological Disease Marker in Patients with Fungal Keratitis |
| Year | 2022 |
| PMID | 35845133 |
| Fungal Diseases involved | Fungal keratitis |
| Associated Medical Condition | None |
| Genus | None |
| Species | None |
| Organism | None |
| Ethical Statement | This study was approved by the Zhongshan Ophthalmic Center Medical Science Research Ethics Committee (protocol number: 2020KYPJ115). |
| Site of Infection | Eye |
| Opportunistic invasive | None |
| Sample type | Biopsy |
| Sample source | Extracted tissue |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | Galectin-3 |
| Biomarker Full Name | Galectin-3 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | China |
| Cohort | The tissue samples were collected from patients who had clinically diagnosed fungal keratitis by corneal scraping culture and received corneal transplantation from May 2020 to May 2021 at the Zhong- shan Ophthalmic Center. Thirty-one fungal keratitis patients with a mean age of 61:30 ± 2:55 years (males 33.33%, females 67.67%) in the early stage and 62:05 ± 1:47 (males 40.91%, females 59.09%) in the late stage were recruited into the study. |
| Cohort No. | 31 |
| Age Group | 61:30 ± 2:55 |
| P Value | p<0:05 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Fungal keratitis (FK), also known as mycotic keratitis, is a severe corneal infection that often results in permanent blindness and vision loss. It is estimated that there are 1051787 new FK cases each year worldwide, with the highest incidence rates in Asia and Africa. The incidence of FK in China is more common than in other regions. The immune responses of fungal keratitis include both anti- infection responses and immune disorders after pathogen invasion. Our previous study demonstrated that triggering receptors expressed on myeloid cells-1 (TREM-1) and den- dritic cell-associated C-type lectin-1 (Dectin-1), the vital pattern recognition receptors (PRRs) in the innate immune response, initiated the whole anti-infection process, posi- tively participated in the pathogenesis of ocular fungal infec- tion, and provided the foundation of the adaptive immune response. However, the mechanism of innate immune response in FK remains unveiled to a great extent. |
| Technique | PCR |
| Analysis Method | qRT-PCR |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | qRT-PCR , Immunofluorescence Staining, Flow Cytometry Analysis, Western Blot Analysis |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
