| DB ID | MyCo_5716 |
| Title | Long noncoding RNA expression profile from cryptococcal meningitis patients identifies DPY19L1p1 as a new disease marker |
| Year | 2019 |
| PMID | 30767376 |
| Fungal Diseases involved | Cryptococcal meningitis |
| Associated Medical Condition | None |
| Genus | Cryptococcus |
| Species | neoformans |
| Organism | Cryptococcus neoformans |
| Ethical Statement | Informed consent was obtained from all subjects, and this study was approved by the ethics committees of the Changhai hospital and Changzheng hospital (Shanghai, China). |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | DPY19L1p1 |
| Biomarker Full Name | DPY19L1p1 |
| Biomarker Type | Diagnostic |
| Biomolecule | Gene |
| Geographical Location | China |
| Cohort | A 5 mL volume of venous blood was collected from twenty cryptococcal meningitis patients and eighteen healthy donors from the Changhai hospital and Changzheng hospital. The diagnosis of cryptococcal meningitis was based on India ink staining and/or positive culture of C. neoformans from cerebrospinal fluid.12 The age and gender of the healthy control and the cryptococcal meningitis groups were not significantly different. |
| Cohort No. | 20 |
| Age Group | None |
| P Value | p<0.0001 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Cryptococcal meningitis, a severe central nervous system infection diseases, accounts for 15% of the AIDS‐related mortality Lei Zhang, Wen‐Jie Fang and Ke‐Ming Zhang contributed equally to this work. worldwide. In immunocompetent individuals, Cryptococcus neoformans primarily causes asymptomatic clinical manifestations or latent infection; most people have a history of C. neoformans exposure in early childhood.2 With the growing population of patients with AIDS or organ transplantation history, the incidence of cryptococcosis has tended to increase. |
| Technique | PCR |
| Analysis Method | qRT-PCR |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Microarray analysis, qRT-PCR |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
