| DB ID | MyCo_5518 |
| Title | Encephalitozoonosis in pharmacologically immunosuppressed mice |
| Year | 2012 |
| PMID | 22626517 |
| Fungal Diseases involved | Encephalitozoonosis |
| Associated Medical Condition | None |
| Genus | Encephalitozoon |
| Species | cuniculi |
| Organism | Encephalitozoon cuniculi |
| Ethical Statement | Here used the euthanasia protocol approved by the Ethics Committee of the Paulista University, protocol number 020/08. |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Biopsy |
| Sample source | Extracted Liver tissue |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | CD4 |
| Biomarker Full Name | CD4 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Brazil |
| Cohort | Inbred, specific pathogen free (SPF), 30 to 40 day-old BALB/c male mice were maintained under standard animal housing condi- tions with Purina chow and water, ad libitum. The animals were housed in accordance with the principles of laboratory animal care and laws on animal use. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Microsporidia are ubiquitous, intracellular, spore-forming, obli- gate parasites that infect both humans and animals. They are currently considered to be highly derived fungi descendent from a zygomycete ancestor. Of more than 1200 species described to date, 14 species of microsporidia were found to be important opportunistic pathogens in humans. Encephalitozoon can infected most tissues, and Encephalitozoon cuniculi has been shown to cause nephritis, as well as secondary infections of the heart, brain, kidneys, and even the tongue. Although infection may occur in most tissues of the body, leading to various symptoms depending on the infection site, by far, the most common presentation of the disease is diarrhea. In immuno- compromised individuals, chronic diarrhea may persist and lead to malabsorption of nutrients and wasting. |
| Technique | PCR |
| Analysis Method | PCR Based |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | PCR |
| Up Regulation Down Regulation | Decrease |
| Sequence Data | None |
| External Link | None |
