| DB ID | MyCo_5145 |
| Title | Monitoring neonatal fungal infection with metabolomics |
| Year | 2014 |
| PMID | 25284175 |
| Fungal Diseases involved | Neonatal Fungal infection |
| Associated Medical Condition | None |
| Genus | Candida |
| Species | parapsilosis |
| Organism | Candida parapsilosis |
| Ethical Statement | The ethical committee (Azienda Ospedaliera Universitaria, University of Cagliari, Cagliari, Italy approved the study protocol and written informed consent was obtained from the parents before enrolment in the study. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Urine |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | D-Serine |
| Biomarker Full Name | D-Serine |
| Biomarker Type | Diagnostic |
| Biomolecule | Metabolite |
| Geographical Location | Italy |
| Cohort | This study was carried out on two groups of urine samples from patients admitted to the NICU of the University of Palermo. The study population included a clinical case of a preterm neonate with invasive fungal infection and 13 healthy preterm controls. |
| Cohort No. | None |
| Age Group | None |
| P Value | p=0.00012 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | In Neonatal Intensive Care Unit (NICU), fungal infections are the third leading cause of late onset sepsis among very low birth weight neonates (below 1.5 kg). Besides the low birth weight, other risk factors such as antibiotic therapy, parenteral nutrition, presence a central venous catheter and abdominal surgery are the most frequent in infections by fungi. The short-term complications are characterized by kidney injury, meningitis and endocarditis; whereas long-term complications are above all neurodevelopmental problems. Among the affected newborns, the mortality rate is around 30%. |
| Technique | Gas chromatography |
| Analysis Method | Metabolomics Approach |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | GC-MS |
| Up Regulation Down Regulation | Up regulated |
| Sequence Data | None |
| External Link | None |
