| DB ID | MyCo_5025 |
| Title | Soluble intercellular adhesion molecule (ICAM)-1 detects invasive fungal infections in patients following liver transplantation |
| Year | 2020 |
| PMID | 32803993 |
| Fungal Diseases involved | Invasive fungal infection |
| Disease | Aspergillosis (Aspergillus Infection) |
| Associated Medical Condition | liver transplantation |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | The study took place in the surgical intensive care unit of the Heidelberg University Hospital in the years 2014 2016, after approval by the local ethics committee (Ethics Committee of the Medical Faculty of Heidelberg, Trial Code No. S-098/2013/German Clinical Trials Register: DRKS00005480) All included patients gave written informed consent. |
| Site of Infection | Unspecified |
| Opportunistic invasive | Invasive |
| Sample type | Body fluid |
| Sample source | Plasma |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | sICAM-1 |
| Biomarker Full Name | Soluble intercellular adhesion molecule (ICAM)-1 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Germany |
| Cohort | Culture-based fungal findings, routinely used biomarkers of infection/inflammation (e.g., pro- calcitonin or C-reactive protein), as well as corresponding plasma concentrations of soluble Intercellular Adhesion Molecule (ICAM)-1 were analysed in 93 patients during a period of 28 days fol lowing liver transplantation (LTX). |
| Cohort No. | 93 |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Sub Technique | LC-MS |
| Technique | Mass Spectrometry |
| Analysis Method | Mass spectrometry analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Mass spectrometry analysis |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
